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Invitrogen
RSPO2 Polyclonal Antibody
FIGURE: 1 / 3
RSPO2 Antibody (PA5-25188) in IHC (P)
Immunohistochemistry analysis of RSPO2 in formalin fixed and paraffin embedded human lung carcinoma. Samples were incubated with RSPO2 polyclonal antibody (Product # PA5-25188) followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of this antibody for immunohistochemistry. Clinical relevance has not been evaluated.
Product Details
PA5-25188
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 190-218 amino acids from the C-terminal region of human RSPO2
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A, Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2542688
Product Specific Information
This antibody is predicted to react with mouse based on sequence homology.
Target Information
The R-Spondin (Rspo) proteins belong to the Rspo family of Wnt modulators. Currently, the family consists of four structurally-related, secreted ligands (Rspo 1-4), all containing furin-like and thrombospondin structural domains. The Rspo proteins can interact with the Frizzled/LRP6 receptor complex in a manner that causes the stabilization, and resulting accumulation, of the intracellular signaling protein, beta-catenin. This activity effectively activates and increases the subsequent nuclear signaling of beta-catenin. R-Spondin can also bind to the previously discovered G-protein coupled receptors, LGR-4 and LGR-5. Rspo/beta-catenin signaling can act as an inducer of the transformed phenotype, and can also regulate the proliferation and differentiation of certain stem cell populations.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: hRspo2; R-spondin 2 homolog; R-spondin-2; Roof plate-specific spondin-2
Gene Aliases: CRISTIN2; RSPO2; UNQ9384/PRO34209
UniProt ID: (Human) Q6UXX9
Entrez Gene ID: (Human) 340419
osteoblast differentiation
Wnt signaling pathway
positive regulation of Wnt signaling pathway
bone mineralization
embryonic forelimb morphogenesis
embryonic hindlimb morphogenesis
negative regulation of odontogenesis of dentin-containing tooth
lung growth
epithelial tube branching involved in lung morphogenesis
trachea cartilage morphogenesis
dopaminergic neuron differentiation
positive regulation of canonical Wnt signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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