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Product Details
15996-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
RTCD1 Fusion Protein Ag8904 (1-379 aa encoded by BC012604)
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MAGPRVEVD GSIMEGGGQI LRVSTALSCL LGLPSRVQKI RAGRSTPGLS SGGWKSKIKV LTRPQHLSGL EMIRDLCDGQ LEGAEIGSTE ITFTPEKIKG GIHTADTKTA GSVCLLMQVS MPCVLFAASP SELHLKGGTN AEMAPQIDYT VMVFKPIVEK FGFIFNCDIK TRGYYPKGGG EVIVRMSPVK QLNPINLTER GCVTKIYGRA FVAGVLPFKV AKDMAAAAVR CIRKEIRDLY VNIQPVQEPK DQAFGNGNGI IIIAETSTGC LFAGSSLGKR GVNADKVGIE AAEMLLANLR HGGTVDEYLQ DQLIVFMALA NGVSRIKTGP VTLHTQTAIH FAEQIAKAKF IVKKSEDEED AAKDTYIIEC QGIGMTNPNL (1-379 aa encoded by BC012604)
Target Information
RTCD1 catalyzes the conversion of 3'-phosphate to a 2', 3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) the enzyme acts on RNA-N3'P to produce RNA-N3'PP5'A; (C) a non catalytic nucleophilic attack by the adjacent 2'hydroxyl on the phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing. There are two named isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: RNA 3'-terminal phosphate cyclase; RNA cyclase; RNA terminal phosphate cyclase domain 1; RNA terminal phosphate cyclase domain-containing protein 1; RNA-3'-phosphate cyclase; RTC domain-containing protein 1
Gene Aliases: 2310009A18Rik; AI450277; RPC; RPC1; RTC1; RTCA; RTCD1
UniProt ID: (Human) O00442, (Mouse) Q9D7H3
Entrez Gene ID: (Human) 8634, (Mouse) 66368, (Rat) 295395
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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