Proteintech

RTN3 Polyclonal Antibody

RTN3 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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RTN3 Antibody (12055-2-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human gliomas tissue slide using 12055-2-AP ( RTN3 antibody) at dilution of 1:200 (under 40x lens) heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

RTN3 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

12055-2-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:3,000

View 13 publications 13 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

View 4 publications 4 publications

Immunoprecipitation (IP)

0.5-4.0 µg

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

RTN3 Fusion Protein Ag2685 (1-236 aa encoded by BC011394)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.27 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MAEPSAATQ SHSISSSSFG AEPSAPGGGG SPGACPALGT KSCSSSCAVH DLIFWRDVKK TGFVFGTTLI MLLSLAAFSV ISVVSYLILA LLSVTISFRI YKSVIQAVQK SEEGHPFKAY LDVDITLSSE AFHNYMNAAM VHINRALKLI IRLFLVEDLV DSLKLAVFMW LMTYVGAVFN GITLLILAEL LIFSVPIVYE KYKTQIDHYV GIARDQTKSI VEKIQAKLPG IAKKKAE (1-236 aa encoded by BC011394)

Target Information

RTN3 is a member of reticulons, which are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. Alternatively spliced transcript variants encoding different isoforms have been identified. Multiple promoters rather than alternative splicing of internal exons seem to be involved in this diversity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Heteromeric clusters of ubiquitinated ER-shaping proteins drive ER-phagy.

Nature

Foronda H,Fu Y,Covarrubias-Pinto A,Bocker HT,González A,Seemann E,Franzka P,Bock A,Bhaskara RM,Liebmann L,Hoffmann ME,Katona I,Koch N,Weis J,Kurth I,Gleeson JG,Reggiori F,Hummer G,Kessels MM,Qualmann B,Mari M,Dikić I,Hübner CA

Thu Jun 01 00:00:00 UTC 2023

CCPG1 recognizes endoplasmic reticulum luminal proteins for selective ER-phagy.

Molecular biology of the cell

Ishii S,Chino H,Ode KL,Kurikawa Y,Ueda HR,Matsuura A,Mizushima N,Itakura E

Sat Apr 01 00:00:00 UTC 2023

Fibroblast exosomal TFAP2C induced by chitosan oligosaccharides promotes peripheral axon regeneration via the miR-132-5p/CAMKK1 axis.

Bioactive materials

Zhao Y,Liu J,Liu S,Yang P,Liang Y,Ma J,Mao S,Sun C,Yang Y

Tue Aug 01 00:00:00 UTC 2023

Deficiency of Perry syndrome-associated p150^Glued in midbrain dopaminergic neurons leads to progressive neurodegeneration and endoplasmic reticulum abnormalities.

NPJ Parkinson's disease

Yu J,Yang X,Zheng J,Sgobio C,Sun L,Cai H

Tue Mar 07 00:00:00 UTC 2023

Deficiency of Perry syndrome-associated p150^Glued in midbrain dopaminergic neurons leads to progressive neurodegeneration and endoplasmic reticulum abnormalities.

NPJ Parkinson's disease

Yu J,Yang X,Zheng J,Sgobio C,Sun L,Cai H

Tue Mar 07 00:00:00 UTC 2023

Melatonin restores endoplasmic reticulum homeostasis to protect injured neurons in a rat model of chronic cervical cord compression.

Journal of pineal research

Yao M,Pu PM,Li ZY,Zhu K,Zhou LY,Sun YL,Dai YX,Cui XJ,Wang YJ

Mon May 01 00:00:00 UTC 2023

Transverse endoplasmic reticulum expansion in hereditary spastic paraplegia corticospinal axons.

Human molecular genetics

Zhu PP,Hung HF,Batchenkova N,Nixon-Abell J,Henderson J,Zheng P,Renvoisé B,Pang S,Xu CS,Saalfeld S,Funke J,Xie Y,Svara F,Hess HF,Blackstone C

Tue Aug 23 00:00:00 UTC 2022

ER proteins decipher the tubulin code to regulate organelle distribution.

Nature

Zheng P,Obara CJ,Szczesna E,Nixon-Abell J,Mahalingan KK,Roll-Mecak A,Lippincott-Schwartz J,Blackstone C

Sat Jan 01 00:00:00 UTC 2022

Liver X receptor-agonist treatment rescues degeneration in a Drosophila model of hereditary spastic paraplegia.

Acta neuropathologica communications

Byrne DJ,Garcia-Pardo ME,Cole NB,Batnasan B,Heneghan S,Sohail A,Blackstone C,O'Sullivan NC

Mon Mar 28 00:00:00 UTC 2022

Liver X receptor-agonist treatment rescues degeneration in a Drosophila model of hereditary spastic paraplegia.

Acta neuropathologica communications

Byrne DJ,Garcia-Pardo ME,Cole NB,Batnasan B,Heneghan S,Sohail A,Blackstone C,O'Sullivan NC

Mon Mar 28 00:00:00 UTC 2022

Liver X receptor-agonist treatment rescues degeneration in a Drosophila model of hereditary spastic paraplegia.

Acta neuropathologica communications

Byrne DJ,Garcia-Pardo ME,Cole NB,Batnasan B,Heneghan S,Sohail A,Blackstone C,O'Sullivan NC

Mon Mar 28 00:00:00 UTC 2022

TAOK2 is an ER-localized kinase that catalyzes the dynamic tethering of ER to microtubules.

Developmental cell

Nourbakhsh K,Ferreccio AA,Bernard MJ,Yadav S

Mon Dec 20 00:00:00 UTC 2021

Quantitative Proteomics and Differential Protein Abundance Analysis after the Depletion of PEX3 from Human Cells Identifies Additional Aspects of Protein Targeting to the ER.

International journal of molecular sciences

Zimmermann R,Lang S,Lerner M,Förster F,Nguyen D,Helms V,Schrul B

Wed Dec 01 00:00:00 UTC 2021

Knockdown of Long Non-Coding RNA AFAP1-AS1 Promoted Viability and Suppressed Death of Cardiomyocytes in Response to I/R In Vitro and In Vivo.

Journal of cardiovascular translational research

Chen Z,Wang X,Hou X,Ding F,Yi K,Zhang P,You T

Tue Dec 01 00:00:00 UTC 2020

Intrinsically Disordered Protein TEX264 Mediates ER-phagy.

Molecular cell

Chino H,Hatta T,Natsume T,Mizushima N

Thu Jun 06 00:00:00 UTC 2019

ATL3 Is a Tubular ER-Phagy Receptor for GABARAP-Mediated Selective Autophagy.

Current biology : CB

Chen Q,Xiao Y,Chai P,Zheng P,Teng J,Chen J

Mon Mar 04 00:00:00 UTC 2019

TMCC3 localizes at the three-way junctions for the proper tubular network of the endoplasmic reticulum.

The Biochemical journal

Wisesa S,Yamamoto Y,Sakisaka T

Fri Nov 15 00:00:00 UTC 2019

The peroxisome biogenesis factors posttranslationally target reticulon homology domain-containing proteins to the endoplasmic reticulum membrane.

Scientific reports

Yamamoto Y,Sakisaka T

Fri Feb 02 00:00:00 UTC 2018

The peroxisome biogenesis factors posttranslationally target reticulon homology domain-containing proteins to the endoplasmic reticulum membrane.

Scientific reports

Yamamoto Y,Sakisaka T

Fri Feb 02 00:00:00 UTC 2018

Enterovirus 71 protease 2Apro and 3Cpro differentially inhibit the cellular endoplasmic reticulum-associated degradation (ERAD) pathway via distinct mechanisms, and enterovirus 71 hijacks ERAD component p97 to promote its replication.

PLoS pathogens

Wang T,Wang B,Huang H,Zhang C,Zhu Y,Pei B,Cheng C,Sun L,Wang J,Jin Q,Zhao Z

Sun Oct 01 00:00:00 UTC 2017

PLoS pathogens

Wang T,Wang B,Huang H,Zhang C,Zhu Y,Pei B,Cheng C,Sun L,Wang J,Jin Q,Zhao Z

Sun Oct 01 00:00:00 UTC 2017

Bioinformatics

Protein Aliases: ASY interacting protein; HAP; Homolog of ASY protein; Neuroendocrine-specific protein-like 2; Neuroendocrine-specific protein-like II; nsp-c; NSP-like protein 2; NSP-like protein II; Reticulon-3

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Gene Aliases: ASYIP; HAP; NSPL2; NSPLII; RTN3; RTN3-A1

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UniProt ID: (Human) O95197

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Entrez Gene ID: (Human) 10313

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Function(s)

protein binding

Process(es)

apoptotic process chemical synaptic transmission viral process vesicle-mediated transport endoplasmic reticulum tubular network organization endoplasmic reticulum tubular network assembly

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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RTN3 Polyclonal Antibody

RTN3 Antibody (12055-2-AP) in IHC (P)

Product Details

12055-2-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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