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RTN4/NOGO Polyclonal Antibody

RTN4/NOGO Antibody in Immunocytochemistry (ICC/IF)

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RTN4/NOGO Antibody (10950-1-AP) in ICC/IF

Immunofluorescent analysis of A375 cells using 10950-1-AP (RTN4/NOGO antibody) at dilution of 1:25 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

RTN4/NOGO Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Product Details

10950-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 7 publications 7 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:10-1:100

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

RTN4/NOGO Fusion Protein Ag1392 (1-373 aa encoded by BC012619)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.17 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MEDLDQSPL VSSSDSPPRP QPAFKYQFVR EPEDEEEEEE EEEEDEDEDL EELEVLERKP AAGLSAAPVP TAPAAGAPLM DFGNDFVPPA PRGPLPAAPP VAPERQPSWD PSPVSSTVPA PSPLSAAAVS PSKLPEDDEP PARPPPPPPA SVSPQAEPVW TPPAPAPAAP PSTPAAPKRR GSSGSVVVDL LYWRDIKKTG VVFGASLFLL LSLTVFSIVS VTAYIALALL SVTISFRIYK GVIQAIQKSD EGHPFRAYLE SEVAISEELV QKYSNSALGH VNCTIKELRR LFLVDDLVDS LKFAVLMWVF TYVGALFNGL TLLILALISL FSVPVIYERH QAQIDHYLGL ANKNVKDAMA KIQAKIPGLK RKAE (1-373 aa encoded by BC012619)

Target Information

NogoA is a member of a family of integral membrane proteins termed reticulons that are thought to be involved in numerous disorders including neurodegenerative diseases. Reticulon proteins are known to regulate many cellular processes and interact with multiple proteins and receptors such as BACE. NogoA was initially identified as a myelin-associated neurite outgrowth inhibitor. It is highly expressed in oligodendrocytes in the white matter of the CNS, blocking its activity with antibodies or other factors results in improved axon regrowth and functional recovery in experimental CNS lesion models. NogoA has also been suggested to play a role in neurodegenerative diseases such as Amyotrophic lateral sclerosis, in which case NogoA is found at elevated levels in postmortem muscular samples, and multiple sclerosis (MS), in which case autoantibodies to NogoA have been found in serum and cerebrospinal fluid in MS patients.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Nogo-B inhibition restricts ulcerative colitis via inhibiting p68/miR-155 signaling pathway.

International immunopharmacology

Zheng J,Wang S,Zhang T,Li H,Zhu M,Wei X,Ge Y,Yang X,Zhang S,Xu H,Duan Y,Liu L,Chen Y

Sat Jul 01 00:00:00 UTC 2023

Nogo-B inhibition restricts ulcerative colitis via inhibiting p68/miR-155 signaling pathway.

International immunopharmacology

Zheng J,Wang S,Zhang T,Li H,Zhu M,Wei X,Ge Y,Yang X,Zhang S,Xu H,Duan Y,Liu L,Chen Y

Sat Jul 01 00:00:00 UTC 2023

Deficiency of Perry syndrome-associated p150^Glued in midbrain dopaminergic neurons leads to progressive neurodegeneration and endoplasmic reticulum abnormalities.

NPJ Parkinson's disease

Yu J,Yang X,Zheng J,Sgobio C,Sun L,Cai H

Tue Mar 07 00:00:00 UTC 2023

SEC24A facilitates colocalization and Ca²⁺ flux between the endoplasmic reticulum and mitochondria.

Journal of cell science

Chidawanyika T,Chakrabarti R,Beauchemin KS,Higgs HN,Supattapone S

Fri Mar 26 00:00:00 UTC 2021

Tanshinone IIA Promotes Axonal Regeneration in Rats with Focal Cerebral Ischemia Through the Inhibition of Nogo-A/NgR1/RhoA/ROCKII/MLC Signaling.

Drug design, development and therapy

Wang J,Ni G,Liu Y,Han Y,Jia L,Wang Y

Thu Jul 01 00:00:00 UTC 2021

Reticulon and CLIMP-63 regulate nanodomain organization of peripheral ER tubules.

PLoS biology

Gao G,Zhu C,Liu E,Nabi IR

Thu Aug 01 00:00:00 UTC 2019

Dengue and Zika viruses subvert reticulophagy by NS2B3-mediated cleavage of FAM134B.

Autophagy

Lennemann NJ,Coyne CB

Wed Feb 01 00:00:00 UTC 2017

Dengue and Zika viruses subvert reticulophagy by NS2B3-mediated cleavage of FAM134B.

Autophagy

Lennemann NJ,Coyne CB

Wed Feb 01 00:00:00 UTC 2017

Dengue and Zika viruses subvert reticulophagy by NS2B3-mediated cleavage of FAM134B.

Autophagy

Lennemann NJ,Coyne CB

Wed Feb 01 00:00:00 UTC 2017

Dengue and Zika viruses subvert reticulophagy by NS2B3-mediated cleavage of FAM134B.

Autophagy

Lennemann NJ,Coyne CB

Wed Feb 01 00:00:00 UTC 2017

Erythropoietin attenuates axonal injury after middle cerebral artery occlusion in mice.

Neurological research

Wang R,Zhao H,Li J,Duan Y,Fan Z,Tao Z,Ju F,Yan F,Luo Y

Thu Jun 01 00:00:00 UTC 2017

Erythropoietin attenuates axonal injury after middle cerebral artery occlusion in mice.

Neurological research

Wang R,Zhao H,Li J,Duan Y,Fan Z,Tao Z,Ju F,Yan F,Luo Y

Thu Jun 01 00:00:00 UTC 2017

Bioinformatics

Protein Aliases: Foocen; Human NogoA; My043 protein; neurite growth inhibitor 220; Neurite outgrowth inhibitor; Neuroendocrine-specific protein; Neuroendocrine-specific protein C homolog; Nogo protein; NSP; reticulon 5; Reticulon-4; Reticulon-5; RTN-x

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Gene Aliases: 1110020G17Rik; AA407876; AA409940; AA960376; ASY; C130026I10Rik; KIAA0886; mKIAA0886; mKIAA4153; My043; Nbla00271; Nbla10545; NgA; NI220/250; NOGO; NOGO-A; Nogo-B; Nogo-C; NOGOC; NSP; NSP-CL; RTN-X; RTN4; RTN4-A; RTN4-B1; RTN4-B2; RTN4-C; SP1507

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UniProt ID: (Human) Q9NQC3, (Mouse) Q99P72

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Entrez Gene ID: (Human) 57142, (Mouse) 68585

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Function(s)

protein binding poly(A) RNA binding cadherin binding involved in cell-cell adhesion protein complex binding

Process(es)

angiogenesis nervous system development axonogenesis axonal fasciculation negative regulation of neuron projection development cerebral cortex radial glia guided migration negative regulation of cell growth regulation of cell migration negative regulation of axon extension positive regulation of dopamine secretion negative regulation of neuron differentiation positive regulation of glial cell differentiation negative regulation of axonogenesis regulation of sensory perception of pain regulation of nervous system development cardiac epithelial to mesenchymal transition negative regulation of neuron projection regeneration endoplasmic reticulum tubular network organization regulation of branching morphogenesis of a nerve apoptotic process regulation of apoptotic process nuclear pore complex assembly endoplasmic reticulum tubular network assembly cell-cell adhesion

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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RTN4/NOGO Polyclonal Antibody

RTN4/NOGO Antibody (10950-1-AP) in ICC/IF

Product Details

10950-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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