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Immunogen sequence: DGLEKTNSKL QEELSAATDR ICSLQEEQQQ LREQNELIRE RSEKSVEITK QDTKVELETY KQTRQGLDEM YSDVWKQLK
Highest antigen sequence identity to the following orthologs: Mouse - 97%, Rat - 100%.
This gene encodes a protein that contains a RUN domain and a FYVE-type zinc finger domain. The encoded protein binds to phosphatidylinositol-3-phosphate (PI3P) and plays a role in early endosomal trafficking, tethering and fusion through interactions with small GTPases including Rab4, Rab5 and Rab14. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: FYVE-finger containing protein; FYVE-finger protein EIP1; La-binding protein 1; Rab4-interacting protein; Rab4a interacting protein; RUN and FYVE domain-containing protein 1; Zinc finger FYVE domain-containing protein 12
Gene Aliases: 3000002E04Rik; RABIP4; RUFY1; ZFYVE12
UniProt ID: (Human) Q96T51, (Mouse) Q8BIJ7
Entrez Gene ID: (Human) 80230, (Mouse) 216724, (Rat) 360521
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