Bioss

RUNX1/RUNX2 Polyclonal Antibody

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

BS-1134R

Applications
Tested Dilution
Publications

Western Blot (WB)

1:300
-

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:400
-

Immunohistochemistry (Frozen) (IHC (F))

1:100-1:500
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

Flow Cytometry (Flow)

1:20-1:100
-

ELISA (ELISA)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Guinea pig, Human, Mouse, Rabbit, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide derived from human RUNX2.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA

Contains

0.02% ProClin 300

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE). Inhibits KAT6B-dependent transcriptional activation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Acute myeloid leukemia 1 protein; Acute myeloid leukemia 3 protein; AKV core binding factor; AML1-EVI-1 fusion protein; CBF-alpha-1; CBF-alpha-2; core binding factor alpha 1; core binding factor alpha 2; core-binding factor runt domain alpha subunit 2 (acute myeloid leukemia 1 oncogene); Core-binding factor subunit alpha-1; Core-binding factor subunit alpha-2; core-binding factor, runt domain, alpha subunit 1; core-binding factor, runt domain, alpha subunit 2; Oncogene AML-1; Oncogene AML-3; OSF-2; Osteoblast-specific transcription factor 2; PEA2-alpha A; PEA2-alpha B; PEBP2 alpha A; PEBP2-alpha A; PEBP2-alpha B; Polyomavirus enhancer-binding protein 2 alpha A subunit; Polyomavirus enhancer-binding protein 2 alpha B subunit; runt domain, alpha subunit 1; runt domain, alpha subunit 2; runt related transcription factor 1; runt related transcription factor 2; Runt-related transcription factor 1; Runt-related transcription factor 2; RUNX1/ZNF687 fusion; SL3-3 enhancer factor 1 alpha A subunit; SL3-3 enhancer factor 1 alpha B subunit; SL3/AKV core-binding factor alpha A subunit; SL3/AKV core-binding factor alpha B subunit; transcription factor

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Gene Aliases: AML1; AML1-EVI-1; AML3; AMLCR1; Cbf; CBF-alpha-1; CBF-alpha-2; CBF2alpha; Cbfa-1; CBFA1; CBFA2; CCD; CCD1; CLCD; EVI-1; LS3; OSF-2; OSF2; PEA2aA; PEBP2A; Pebp2a1; Pebp2a2; PEBP2aA; PEBP2aB; PEBP2alpha; Pebpa2a; Pebpa2b; RUNX1; RUNX2

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UniProt ID: (Human) Q01196, (Human) Q13950, (Rat) Q63046, (Mouse) Q08775

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Entrez Gene ID: (Rabbit) 100358993, (Human) 861, (Human) 860, (Rabbit) 100008943, (Rat) 50662, (Mouse) 12394, (Rat) 367218, (Mouse) 12393

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Function(s)
regulatory region DNA binding RNA polymerase II regulatory region sequence-specific DNA binding core promoter binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding protein binding ATP binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding chromatin binding transcription factor activity, sequence-specific DNA binding protein domain specific binding histone deacetylase binding bHLH transcription factor binding repressing transcription factor binding molecular_function DNA binding calcium ion binding transcription factor binding protein homodimerization activity protein heterodimerization activity transcription regulatory region DNA binding
Process(es)
skeletal system development osteoblast differentiation endochondral ossification osteoblast fate commitment chondrocyte differentiation chondrocyte development osteoblast development transcription, DNA-templated regulation of transcription, DNA-templated transcription from RNA polymerase II promoter positive regulation of cell proliferation positive regulation of gene expression T cell differentiation regulation of ossification BMP signaling pathway positive regulation of chondrocyte differentiation embryonic forelimb morphogenesis regulation of fibroblast growth factor receptor signaling pathway odontogenesis of dentin-containing tooth regulation of odontogenesis of dentin-containing tooth cellular response to fibroblast growth factor stimulus regulation of osteoblast differentiation positive regulation of osteoblast differentiation positive regulation of ossification negative regulation of smoothened signaling pathway negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter cell maturation embryonic cranial skeleton morphogenesis skeletal system morphogenesis stem cell differentiation cellular response to BMP stimulus positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus ossification hemopoiesis positive regulation of granulocyte differentiation positive regulation of interleukin-2 production positive regulation of angiogenesis peripheral nervous system neuron development hematopoietic stem cell proliferation in utero embryonic development liver development myeloid progenitor cell differentiation central nervous system development negative regulation of cell proliferation regulation of signal transduction myeloid cell differentiation neuron differentiation negative regulation of granulocyte differentiation hair follicle morphogenesis response to retinoic acid embryonic hemopoiesis behavioral response to pain neuron development definitive hemopoiesis regulation of hair follicle cell proliferation cellular response to transforming growth factor beta stimulus positive regulation of cell maturation positive regulation of progesterone secretion regulation of transcription from RNA polymerase II promoter regulation of cell differentiation regulation of T cell anergy positive regulation of interferon-gamma production
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