Invitrogen

RUNX1/RUNX2/RUNX3 Recombinant Rabbit Monoclonal Antibody (6G5U2)

View all (3) RUNX1/RUNX2/RUNX3 antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

MA5-35649

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

6G5U2

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 354-453 of human RUNX1/2/3 (NP_0010018901)
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.28 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol, 0.05% BSA

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2849549

Product Specific Information

Immunogen sequence: LPPPYPGSSQ AQGGPFQASS PSYHLYYGAS AGSYQFSMVG GERSPPRILP PCTNASTGSA LLNPSLPNQS DVVEAEGSHS NSPTNMAPSA RLEEAVWRPY

Target Information

Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are welldocumented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Acute myeloid leukemia 1 protein; Acute myeloid leukemia 2 protein; Acute myeloid leukemia 3 protein; acute myeloid leukemia gene 2; AKV core binding factor; AML1-EVI-1 fusion protein; CBF-alpha-1; CBF-alpha-2; CBF-alpha-3; core binding factor alpha 1; core binding factor alpha 2; core binding factor alpha 3; Core-binding factor subunit alpha-1; Core-binding factor subunit alpha-2; Core-binding factor subunit alpha-3; core-binding factor, runt domain, alpha subunit 1; core-binding factor, runt domain, alpha subunit 2; core-binding factor, runt domain, alpha subunit 3; Oncogene AML-1; Oncogene AML-2; Oncogene AML-3; OSF-2; Osteoblast-specific transcription factor 2; PEA2 alpha C; PEA2-alpha A; PEA2-alpha B; PEA2-alpha C; PEBP2 alpha A; PEBP2 alpha C; PEBP2-alpha A; PEBP2-alpha B; PEBP2-alpha C; Polyomavirus enhancer-binding protein 2 alpha A subunit; Polyomavirus enhancer-binding protein 2 alpha B subunit; Polyomavirus enhancer-binding protein 2 alpha C subunit; runt domain, alpha subunit 1; runt domain, alpha subunit 2; runt domain, alpha subunit 3; Runt-related transcription factor 1; Runt-related transcription factor 2; Runt-related transcription factor 3; RUNX 2; RUNX-2; RUNX1/ZNF687 fusion; SL3-3 enhancer factor 1 alpha A subunit; SL3-3 enhancer factor 1 alpha B subunit; SL3-3 enhancer factor 1 alpha C subunit; SL3/AKV core-binding factor alpha A subunit; SL3/AKV core-binding factor alpha B subunit; SL3/AKV core-binding factor alpha C subunit; transcription factor; transcription factor AML2; transcription factor AML2/CBFA3

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Gene Aliases: AML1; AML1-EVI-1; AML2; AML3; AMLCR1; Cbf; CBF-alpha-1; CBF-alpha-2; CBF2alpha; Cbfa-1; CBFA1; CBFA2; CBFA3; CCD; CCD1; CLCD; EVI-1; LS3; OSF-2; OSF2; PEA2aA; PEBP2A; Pebp2a1; Pebp2a2; PEBP2A3; PEBP2aA; PEBP2aB; PEBP2aC; PEBP2alpha; Pebpa2a; Pebpa2b; RUNX1; RUNX2; RUNX3

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UniProt ID: (Human) Q01196, (Human) Q13950, (Human) Q13761, (Mouse) Q08775

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Entrez Gene ID: (Human) 861, (Human) 860, (Human) 864, (Mouse) 12394, (Mouse) 12393, (Mouse) 12399

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Function(s)
regulatory region DNA binding RNA polymerase II regulatory region sequence-specific DNA binding core promoter binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding protein binding ATP binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding chromatin binding transcription factor activity, sequence-specific DNA binding protein domain specific binding histone deacetylase binding bHLH transcription factor binding repressing transcription factor binding DNA binding calcium ion binding transcription factor binding protein homodimerization activity protein heterodimerization activity transcription regulatory region DNA binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter ossification chondrocyte differentiation transcription, DNA-templated regulation of transcription, DNA-templated protein phosphorylation axon guidance hemopoiesis neuron differentiation hair follicle morphogenesis neuron projection development interferon-gamma production mRNA transcription from RNA polymerase II promoter regulation of cell differentiation negative regulation of cell cycle cell maturation negative regulation of epithelial cell proliferation positive regulation of extrinsic apoptotic signaling pathway regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter positive regulation of transcription, DNA-templated peripheral nervous system neuron development response to transforming growth factor beta positive regulation of granulocyte differentiation positive regulation of interleukin-2 production positive regulation of angiogenesis positive regulation of transcription from RNA polymerase II promoter hematopoietic stem cell proliferation osteoblast differentiation endochondral ossification osteoblast fate commitment chondrocyte development osteoblast development positive regulation of cell proliferation T cell differentiation BMP signaling pathway positive regulation of chondrocyte differentiation embryonic forelimb morphogenesis regulation of fibroblast growth factor receptor signaling pathway odontogenesis of dentin-containing tooth regulation of odontogenesis of dentin-containing tooth cellular response to fibroblast growth factor stimulus positive regulation of osteoblast differentiation negative regulation of smoothened signaling pathway negative regulation of transcription, DNA-templated embryonic cranial skeleton morphogenesis stem cell differentiation cellular response to BMP stimulus positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus skeletal system development in utero embryonic development liver development myeloid progenitor cell differentiation regulation of T cell anergy central nervous system development negative regulation of cell proliferation regulation of signal transduction myeloid cell differentiation negative regulation of granulocyte differentiation response to retinoic acid positive regulation of interferon-gamma production embryonic hemopoiesis behavioral response to pain neuron development definitive hemopoiesis regulation of hair follicle cell proliferation cellular response to transforming growth factor beta stimulus positive regulation of cell maturation positive regulation of progesterone secretion positive regulation of gene expression regulation of ossification regulation of osteoblast differentiation positive regulation of ossification skeletal system morphogenesis
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