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Abnova
RUSC1 Polyclonal Antibody, MaxPab™
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Product Details
H00023623-B01P
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
RUSC1 (NP_055143.2, 1 a.a. approximately 433 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MAEAQSGTGQ LQEQKKGLLI AVSVSVDKII SHFGAARNLV QKAQLGDSRL SPDVGHLVLT TLCPALHALV ADGLKPFRKD LITGQRRSSP WSVVEASVKP GSSTRSLGTL YSQVSRLAPL SSSRSRFHAF ILGLLNTKQL ELWFSSLQED AGLLSLLYLP TGFFSLARGG CPSLSTELLL LLQPLSVLTF HLDLLFEHHH HLPLGPPQAP APPGPPPALQ QTMQAMLHFG GRLAQSLRGT SKEAASDPSD SPNLPTPGSW WEQLTQASRV YASGGTEGFP LSRWAPGRHG TAAEEGAQER PLPTDEMAPG RGLWLGRLFG VPGGPAENEN GALKSRRPSS WLPPTVSVLA LVKRGAPPEM PSPQELEASA PRMVQTHRAV RALCDHTAAR PDQLSFRRGE VLRVITTVDE DWLRCGRDGM EGLVPVGYTS LVL
Target Information
RUSC1, also known as NESCA, shares with the related protein RUSC2 a common domain structure of RUN, leucine zipper and SH3 domain in addition to over 30% amino acid identity. RUSC1 is an adapter protein that can bind to the TrkA receptor and is necessary in the NGF-induced neurite growth of PC12 cells. RUSC1 has also been shown to interact with Ikappa-B kinase- (IKK-) -gamma, the regulatory subunit of the IKK complex that is required for NF-kappa-B activation in many signaling pathways such as TNF-R or the TLR pathways. RUSC1 can also bind to the E3 ubiquitin ligase TRAF6, which then catalyzes RUSC1 polyubiquitination. Since overexpression of RUSC1 strongly inhibits TRAF6-mediated polyubiquitination of IKK-gamma, RUSC1 may be a link in the IKK-gamma-mediated NF-kappa-B activation pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AP-4 complex accessory subunit RUSC1; Nesca; New molecule containing SH3 at the carboxy-terminus; RP11-21N7.4; RUN and SH3 domain-containing protein 1
Gene Aliases: NESCA; RUSC1
UniProt ID: (Human) Q9BVN2
Entrez Gene ID: (Human) 23623
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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