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Proteintech
RWDD3 Polyclonal Antibody
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Product Details
22737-1-AP
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
RWDD3 Fusion Protein Ag18674 (1-185 aa encoded by BC125142)
Conjugate
Form
Liquid
Concentration
0.55 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MFLSCGSLH QRGPETDGTV FRIHTKAEGF MDADIPLELV FHLPVNYPSC LPGISINSEQ LTRAQCVTVK EKLLEQAESL LSEPMVHELV LWIQQNLRHI LSQPETGSGS EKCTFSTSTT MDDGLWITLL HLDHMRAKTK YVKIVEKWAS DLRLTGRLMF MGVLDSSENL QSRCGLKWKE MQREND (1-185 aa encoded by B C125142)
Target Information
RWDD3 (RSUME), a small RWD-containing protein, has a central role in sumoylation by enhancing SUMO conjugation in the regulatory network of immune-inflammatory signals. RWDD3 increases Ikappa-Beta sumoylation and stability. In addition, RWDD3 inhibits TNF-a-induced kappaB-LUC (Luciferase) reporter activity, showing the functional consequence of Ikappa-Beta increased stability. RSUME-enhanced sumoylation of Ikappa-Beta leads to the inhibition of NF-kappa-Beta activity on two well-known inflammatory genes, IL-8 and cyclooxygenase-2 (Cox-2) and therefore may also favor anti-inflammatory pathways. Expression of RWDD3 was induced under hypoxic conditions and it has a potential role during vascularization. Both BMP-4 and RWDD3 may be interesting targets for inhibiting steps involved in pituitary tumorigenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: RSUME; RWD domain-containing protein 3; RWD domain-containing sumoylation enhancer; RWD-containing sumoylation enhancer
Gene Aliases: RSUME; RWDD3
UniProt ID: (Human) Q9Y3V2
Entrez Gene ID: (Human) 25950
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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