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Invitrogen
RXRG Polyclonal Antibody
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RXRG Antibody (PA5-110337) in IHC (P)
Immunohistochemistry analysis of RXRG in paraffin-embedded mouse testis. Samples were incubated with RXRG Polyclonal antibody (Product # PA5-110337) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
Product Details
PA5-110337
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-137 of human RXRG (NP_008848.1).
Conjugate
Form
Liquid
Concentration
0.41 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2855748
Product Specific Information
Immunogen sequence: MYGNYSHFMK FPAGYGGSPG HTGSTSMSPS AALSTGKPMD SHPSYTDTPV SAPRTLSAVG TPLNALGSPY RVITSAMGPP SGALAAPPGI NLVAPPSSQL NVVNSVSSSE DIKPLPGLPG IGNMNYPSTS PGSLVKH
Target Information
Retinoic Acid (RA; active metabolite of vitamin A) plays a prominent role in regulating the transition of proliferating precursor cells (such as carcinoma cells and neuronal precursors) to postmitotic differentiated cells (Joshi et al., 2005). The Retinoid X Receptors (RXRs) family (RXR alpha, beta, and gamma), preferentially bind 9-cis -RA and regulate gene transcription by forming heterodimers with a second family of RA receptors. RAs have been suggested to potentially play a therapeutic role in cervical cancer (Abu et al., 2005). RAs are known to play key roles in neuronal development and an increasing body of evidence indicates that retinoid signaling may regulate synaptic plasticity and associated learning and memory behaviors (Lane and Bailey, 2005).
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Nuclear receptor subfamily 2 group B member 3; Retinoic acid receptor RXR-gamma; retinoic X receptor gamma-1; retinoid X receptor; Retinoid X receptor gamma; retinoid X receptor, gamma; RXR gamma; RXR gamma-1
Gene Aliases: NR2B3; RXRC; RXRG
UniProt ID: (Human) P48443, (Rat) Q5BJR8, (Mouse) P28705
Entrez Gene ID: (Human) 6258, (Rat) 83574, (Mouse) 20183
transcription, DNA-templated
transcription from RNA polymerase II promoter
peripheral nervous system development
heart development
skeletal muscle tissue development
response to organic cyclic compound
neuron differentiation
regulation of myelination
response to retinoic acid
cellular response to hormone stimulus
steroid hormone mediated signaling pathway
positive regulation of transcription from RNA polymerase II promoter
retinoic acid receptor signaling pathway
protein homotetramerization
positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
transcription initiation from RNA polymerase II promoter
regulation of transcription, DNA-templated
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