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Product Details
PA5-99712
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human RXRG(Accession P48443), corresponding to amino acid residues D180-G230.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2818645
Product Specific Information
Antibody detects endogenous levels of total RXR gamma.
Target Information
Retinoic Acid (RA; active metabolite of vitamin A) plays a prominent role in regulating the transition of proliferating precursor cells (such as carcinoma cells and neuronal precursors) to postmitotic differentiated cells (Joshi et al., 2005). The Retinoid X Receptors (RXRs) family (RXR alpha, beta, and gamma), preferentially bind 9-cis -RA and regulate gene transcription by forming heterodimers with a second family of RA receptors. RAs have been suggested to potentially play a therapeutic role in cervical cancer (Abu et al., 2005). RAs are known to play key roles in neuronal development and an increasing body of evidence indicates that retinoid signaling may regulate synaptic plasticity and associated learning and memory behaviors (Lane and Bailey, 2005).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Nuclear receptor subfamily 2 group B member 3; Retinoic acid receptor RXR-gamma; retinoic X receptor gamma-1; retinoid X receptor; Retinoid X receptor gamma; retinoid X receptor, gamma; RXR gamma; RXR gamma-1
Gene Aliases: NR2B3; RXRC; RXRG
UniProt ID: (Human) P48443, (Rat) Q5BJR8
Entrez Gene ID: (Human) 6258, (Rat) 83574
transcription, DNA-templated
transcription from RNA polymerase II promoter
peripheral nervous system development
heart development
skeletal muscle tissue development
response to organic cyclic compound
neuron differentiation
regulation of myelination
response to retinoic acid
cellular response to hormone stimulus
steroid hormone mediated signaling pathway
positive regulation of transcription from RNA polymerase II promoter
retinoic acid receptor signaling pathway
protein homotetramerization
positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
transcription initiation from RNA polymerase II promoter
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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