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Product Details
PA5-111217
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein corresonding to Human RYK. Recombinant protein control fragment (Product #RP-102981).
Conjugate
Form
Liquid
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2856627
Product Specific Information
Immunogen sequence: SMKRIELDDS ISASSSSQGL SQPSTQTTQY LRADTPNNAT PITSSLGYPT LRIEKNDLRS VTLLEAKGKV KDIAISRERI TLKDVLQEGT FGRIFHGILI DEKDPNKEKQ AFVKTVKDQA SEIQVTMMLT ESCKLRGLHH RNLLPITH
Target Information
RYK is an atypical member of the family of growth factor receptor protein tyrosine kinases, differing from other members at a number of conserved residues in the activation and nucleotide binding domains. This gene product belongs to a subfamily whose members do not appear to be regulated by phosphorylation in the activation segment. It has been suggested that mediation of biological activity by recruitment of a signaling-competent auxiliary protein may occur through an as yet uncharacterized mechanism. A nine nucleotide insertion in some transcripts results in the SLG variant. It is not established whether this is a product of alternative splicing or a second gene, since evidence for a second gene or pseudogene on chromosome 17 exists.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ERK3; hydroxyaryl-protein kinase; JTK5A protein tyrosine kinase; Tyrosine-protein kinase RYK
Gene Aliases: D3S3195; JTK5; JTK5A; RYK; RYK1
UniProt ID: (Human) P34925
Entrez Gene ID: (Human) 6259
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
transmembrane signaling receptor activity
frizzled binding
protein binding
ATP binding
Wnt-protein binding
Wnt-activated receptor activity
coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway
protein phosphorylation
signal transduction
axonogenesis
axon guidance
synapse assembly
Wnt signaling pathway
peptidyl-tyrosine phosphorylation
neurogenesis
corpus callosum development
neuron differentiation
neuron projection development
cell proliferation in midbrain
non-canonical Wnt signaling pathway
chemorepulsion of dopaminergic neuron axon
positive regulation of MAPK cascade
canonical Wnt signaling pathway
commissural neuron axon guidance
planar cell polarity pathway involved in axon guidance
midbrain dopaminergic neuron differentiation
Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation
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