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Invitrogen
RYK Polyclonal Antibody
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RYK Antibody (PA5-14733) in IHC (P)
Immunohistochemistry analysis of RYK in formalin-fixed and paraffin-embedded human cancer tissue. Samples were incubated with RYK polyclonal antibody (Product # PA5-14733) which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatoca... View More
Product Details
PA5-14733
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 160-190 amino acids from human RYK
Conjugate
Form
Liquid
Concentration
0.4 mg/mL
Purification
Antigen affinity chromatography, Protein A
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2285487
Target Information
RYK is an atypical member of the family of growth factor receptor protein tyrosine kinases, differing from other members at a number of conserved residues in the activation and nucleotide binding domains. This gene product belongs to a subfamily whose members do not appear to be regulated by phosphorylation in the activation segment. It has been suggested that mediation of biological activity by recruitment of a signaling-competent auxiliary protein may occur through an as yet uncharacterized mechanism. A nine nucleotide insertion in some transcripts results in the SLG variant. It is not established whether this is a product of alternative splicing or a second gene, since evidence for a second gene or pseudogene on chromosome 17 exists.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ERK3; growth factor receptor; hydroxyaryl-protein kinase; JTK5A protein tyrosine kinase; Kinase VIK; Met-related kinase; NYK-R; Tyrosine-protein kinase RYK
Gene Aliases: AW536699; D3S3195; ERK-3; JTK5; JTK5A; Mrk; RYK; RYK1; Vik
UniProt ID: (Human) P34925, (Mouse) Q01887
Entrez Gene ID: (Human) 6259, (Rat) 140585, (Mouse) 20187
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
transmembrane signaling receptor activity
frizzled binding
protein binding
ATP binding
Wnt-protein binding
Wnt-activated receptor activity
coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway
nucleotide binding
protein kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
protein phosphorylation
signal transduction
axonogenesis
axon guidance
Wnt signaling pathway
peptidyl-tyrosine phosphorylation
corpus callosum development
neuron differentiation
neuron projection development
positive regulation of MAPK cascade
skeletal system morphogenesis
negative regulation of axon extension involved in axon guidance
negative chemotaxis
commissural neuron axon guidance
phosphorylation
synapse assembly
neurogenesis
cell proliferation in midbrain
non-canonical Wnt signaling pathway
chemorepulsion of dopaminergic neuron axon
canonical Wnt signaling pathway
planar cell polarity pathway involved in axon guidance
midbrain dopaminergic neuron differentiation
Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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