Proteintech

Rab18 Polyclonal Antibody

Rab18 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Rab18 Antibody (11304-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded Mouse brain tissue slide using (Product # 11304-1-AP) Rab18 antibody at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

Rab18 Antibody in Immunohistochemistry (PFA fixed) (IHC (PFA))

Rab18 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

11304-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 12 publications 12 publications

Immunohistochemistry (IHC)

View 6 publications 6 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunohistochemistry (PFA fixed) (IHC (PFA))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 3 publications 3 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Rab18 Fusion Protein Ag1841 (1-206 aa encoded by BC015014)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.13 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MDEDVLTTL KILIIGESGV GKSSLLLRFT DDTFDPELAA TIGVDFKVKT ISVDGNKAKL AIWDTAGQER FRTLTPSYYR GAQGVILVYD VTRRDTFVKL DNWLNELETY CTRNDIVNML VGNKIDKENR EVDRNEGLKF ARKHSMLFIE ASAKTCDGVQ CAFEELVEKI IQTPGLWESE NQNKGVKLSH REEGQGGGAC GGYCSVL (1-206 aa encoded by BC015014)

Target Information

The protein encoded by this gene is a member of a family of Ras-related small GTPases that regulate membrane trafficking in organelles and transport vesicles. Knockdown studies is zebrafish suggest that this protein may have a role in eye and brain development. Mutations in this gene are associated with Warburg micro syndrome type 3. Alternatively spliced transcript variants have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Perilipin-2 promotes lipid droplet-plasma membrane interactions that facilitate apocrine lipid secretion in secretory epithelial cells of the mouse mammary gland.

Frontiers in cell and developmental biology

Monks J,Orlicky DJ,Libby AE,Dzieciatkowska M,Ladinsky MS,McManaman JL

Thu Oct 31 00:00:00 UTC 2024

KIF3B promotes a PI3K signaling gradient causing changes in a Shh protein gradient and suppressing polydactyly in mice.

Developmental cell

Wang S,Tanaka Y,Xu Y,Takeda S,Hirokawa N

Mon Oct 10 00:00:00 UTC 2022

Pu-erh tea increases the metabolite Cinnabarinic acid to improve circadian rhythm disorder-induced obesity.

Food chemistry

Hu S,Hu C,Luo L,Zhang H,Zhao S,Liu Z,Zeng L

Tue Nov 15 00:00:00 UTC 2022

Fatty Acid Synthase Is Involved in Classical Swine Fever Virus Replication by Interaction with NS4B.

Journal of virology

Liu YY,Liang XD,Liu CC,Cheng Y,Chen H,Baloch AS,Zhang J,Go YY,Zhou B

Tue Aug 10 00:00:00 UTC 2021

Fatty Acid Synthase Is Involved in Classical Swine Fever Virus Replication by Interaction with NS4B.

Journal of virology

Liu YY,Liang XD,Liu CC,Cheng Y,Chen H,Baloch AS,Zhang J,Go YY,Zhou B

Tue Aug 10 00:00:00 UTC 2021

Rab18 Regulates Proliferation, Invasion and Cisplatin Sensitivity Through STAT3 Signaling in Head and Neck Squamous Cell Carcinoma.

OncoTargets and therapy

Ji X,Guo X,Wang Y,Li X,Li H

Thu Apr 14 00:00:00 UTC 2022

Rab18 Regulates Proliferation, Invasion and Cisplatin Sensitivity Through STAT3 Signaling in Head and Neck Squamous Cell Carcinoma.

OncoTargets and therapy

Ji X,Guo X,Wang Y,Li X,Li H

Thu Apr 14 00:00:00 UTC 2022

Rab18 Collaborates with Rab7 to Modulate Lysosomal and Autophagy Activities in the Nervous System: an Overlapping Mechanism for Warburg Micro Syndrome and Charcot-Marie-Tooth Neuropathy Type 2B.

Molecular neurobiology

Nian FS,Li LL,Cheng CY,Wu PC,Lin YT,Tang CY,Ren BS,Tai CY,Fann MJ,Kao LS,Hong CJ,Tsai JW

Sun Sep 01 00:00:00 UTC 2019

Rab18 Collaborates with Rab7 to Modulate Lysosomal and Autophagy Activities in the Nervous System: an Overlapping Mechanism for Warburg Micro Syndrome and Charcot-Marie-Tooth Neuropathy Type 2B.

Molecular neurobiology

Nian FS,Li LL,Cheng CY,Wu PC,Lin YT,Tang CY,Ren BS,Tai CY,Fann MJ,Kao LS,Hong CJ,Tsai JW

Sun Sep 01 00:00:00 UTC 2019

Rab18 overexpression promotes proliferation and chemoresistance through regulation of mitochondrial function in human gastric cancer.

OncoTargets and therapy

Wu B,Qi R,Liu X,Qian L,Wu Z

Wed Mar 30 00:00:00 UTC 2022

Rab18 overexpression promotes proliferation and chemoresistance through regulation of mitochondrial function in human gastric cancer.

OncoTargets and therapy

Wu B,Qi R,Liu X,Qian L,Wu Z

Wed Mar 30 00:00:00 UTC 2022

Rab18 overexpression promotes proliferation and chemoresistance through regulation of mitochondrial function in human gastric cancer.

OncoTargets and therapy

Wu B,Qi R,Liu X,Qian L,Wu Z

Wed Mar 30 00:00:00 UTC 2022

Rab18 overexpression promotes proliferation and chemoresistance through regulation of mitochondrial function in human gastric cancer.

OncoTargets and therapy

Wu B,Qi R,Liu X,Qian L,Wu Z

Wed Mar 30 00:00:00 UTC 2022

Rab18 is not necessary for lipid droplet biogenesis or turnover in human mammary carcinoma cells.

Molecular biology of the cell

Jayson CBK,Arlt H,Fischer AW,Lai ZW,Farese RV,Walther TC

Wed Aug 15 00:00:00 UTC 2018

Rab18 is not necessary for lipid droplet biogenesis or turnover in human mammary carcinoma cells.

Molecular biology of the cell

Jayson CBK,Arlt H,Fischer AW,Lai ZW,Farese RV,Walther TC

Wed Aug 15 00:00:00 UTC 2018

Rab18 is not necessary for lipid droplet biogenesis or turnover in human mammary carcinoma cells.

Molecular biology of the cell

Jayson CBK,Arlt H,Fischer AW,Lai ZW,Farese RV,Walther TC

Wed Aug 15 00:00:00 UTC 2018

Rab18 is not necessary for lipid droplet biogenesis or turnover in human mammary carcinoma cells.

Molecular biology of the cell

Jayson CBK,Arlt H,Fischer AW,Lai ZW,Farese RV,Walther TC

Wed Aug 15 00:00:00 UTC 2018

The RAB GTPase RAB18 modulates macroautophagy and proteostasis.

Biochemical and biophysical research communications

Feldmann A,Bekbulat F,Huesmann H,Ulbrich S,Tatzelt J,Behl C,Kern A

Sat May 06 00:00:00 UTC 2017

The RAB GTPase RAB18 modulates macroautophagy and proteostasis.

Biochemical and biophysical research communications

Feldmann A,Bekbulat F,Huesmann H,Ulbrich S,Tatzelt J,Behl C,Kern A

Sat May 06 00:00:00 UTC 2017

ENU mutagenesis identifies mice modeling Warburg Micro Syndrome with sensory axon degeneration caused by a deletion in Rab18.

Experimental neurology

Cheng CY,Wu JC,Tsai JW,Nian FS,Wu PC,Kao LS,Fann MJ,Tsai SJ,Liou YJ,Tai CY,Hong CJ

Fri May 01 00:00:00 UTC 2015

ENU mutagenesis identifies mice modeling Warburg Micro Syndrome with sensory axon degeneration caused by a deletion in Rab18.

Experimental neurology

Cheng CY,Wu JC,Tsai JW,Nian FS,Wu PC,Kao LS,Fann MJ,Tsai SJ,Liou YJ,Tai CY,Hong CJ

Fri May 01 00:00:00 UTC 2015

Rab18 and a Rab18 GEF complex are required for normal ER structure.

The Journal of cell biology

Gerondopoulos A,Bastos RN,Yoshimura S,Anderson R,Carpanini S,Aligianis I,Handley MT,Barr FA

Mon Jun 09 00:00:00 UTC 2014

Rab18 and a Rab18 GEF complex are required for normal ER structure.

The Journal of cell biology

Gerondopoulos A,Bastos RN,Yoshimura S,Anderson R,Carpanini S,Aligianis I,Handley MT,Barr FA

Mon Jun 09 00:00:00 UTC 2014

MicroRNA-30b/c inhibits non-small cell lung cancer cell proliferation by targeting Rab18.

BMC cancer

Zhong K,Chen K,Han L,Li B

Wed Sep 24 00:00:00 UTC 2014

MicroRNA-30b/c inhibits non-small cell lung cancer cell proliferation by targeting Rab18.

BMC cancer

Zhong K,Chen K,Han L,Li B

Wed Sep 24 00:00:00 UTC 2014

MicroRNA-30b/c inhibits non-small cell lung cancer cell proliferation by targeting Rab18.

BMC cancer

Zhong K,Chen K,Han L,Li B

Wed Sep 24 00:00:00 UTC 2014

MicroRNA-30b/c inhibits non-small cell lung cancer cell proliferation by targeting Rab18.

BMC cancer

Zhong K,Chen K,Han L,Li B

Wed Sep 24 00:00:00 UTC 2014

Rab18 binds to hepatitis C virus NS5A and promotes interaction between sites of viral replication and lipid droplets.

PLoS pathogens

Salloum S,Wang H,Ferguson C,Parton RG,Tai AW

Mon Mar 17 00:00:00 UTC 2014

Rab18 binds to hepatitis C virus NS5A and promotes interaction between sites of viral replication and lipid droplets.

PLoS pathogens

Salloum S,Wang H,Ferguson C,Parton RG,Tai AW

Mon Mar 17 00:00:00 UTC 2014

Hepatitis B virus X protein upregulates oncogene Rab18 to result in the dysregulation of lipogenesis and proliferation of hepatoma cells.

Carcinogenesis

You X,Liu F,Zhang T,Li Y,Ye L,Zhang X

Mon Jul 01 00:00:00 UTC 2013

Hepatitis B virus X protein upregulates oncogene Rab18 to result in the dysregulation of lipogenesis and proliferation of hepatoma cells.

Carcinogenesis

You X,Liu F,Zhang T,Li Y,Ye L,Zhang X

Mon Jul 01 00:00:00 UTC 2013

Hepatitis B virus X protein upregulates oncogene Rab18 to result in the dysregulation of lipogenesis and proliferation of hepatoma cells.

Carcinogenesis

You X,Liu F,Zhang T,Li Y,Ye L,Zhang X

Mon Jul 01 00:00:00 UTC 2013

Hepatitis B virus X protein upregulates oncogene Rab18 to result in the dysregulation of lipogenesis and proliferation of hepatoma cells.

Carcinogenesis

You X,Liu F,Zhang T,Li Y,Ye L,Zhang X

Mon Jul 01 00:00:00 UTC 2013

Bioinformatics

Protein Aliases: GTP-binding protein Rab18; RAB18 small GTPase; Ras-related protein Rab-18

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Gene Aliases: AA959686; RAB18; RAB18LI1; WARBM3

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UniProt ID: (Human) Q9NP72, (Mouse) P35293, (Rat) Q5EB77

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Entrez Gene ID: (Human) 22931, (Mouse) 19330, (Rat) 307039

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Function(s)

GTPase activity protein binding GTP binding GDP binding nucleotide binding

Process(es)

transport intracellular protein transport small GTPase mediated signal transduction multicellular organism development protein transport Rab protein signal transduction lipid particle organization endoplasmic reticulum tubular network organization eye development brain development metabolic process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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Rab18 Polyclonal Antibody

Rab18 Antibody (11304-1-AP) in IHC (P)

Product Details

11304-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunohistochemistry (PFA fixed) (IHC (PFA))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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