Proteintech

Rab23 Polyclonal Antibody

Rab23 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Rab23 Antibody (11101-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human liver cancer tissue slide using 11101-1-AP ( RAB23 Antibody) at dilution of 1:200 (under 40x lens).

Rab23 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

11101-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 8 publications 8 publications

Immunohistochemistry (IHC)

View 4 publications 4 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

View 4 publications 4 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Rab23 Fusion Protein Ag1588 (1-203 aa encoded by BC015021)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.31 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MLEEDMEVA IKMVVVGNGA VGKSSMIQRY CKGIFTKDYK KTIGVDFLER QIQVNDEDVR LMLWDTAGQE EFDAITKAYY RGAQACVLVF STTDRESFEA VSSWREKVVA EVGDIPTVLV QNKIDLLDDS CIKNEEAEAL AKRLKLRFYR TSVKEDLNVN EVFKYLAEKY LQKLKQQIAE DPELTHSSSN KIGVFNTSGG SHSG (1-203 aa encoded by BC015021)

Target Information

The Ras-related superfamily of guanine nucleotide binding proteins includes the R-Ras, Rap, Ral/Rec and Rho/Rab subfamilies. Increasing data suggests an important role for Rab proteins in either endocytosis or in biosynthetic protein transport. The process of transporting newly synthesized proteins from the endoplasmic reticulum to various stacks of the Golgi complex and to secretory vesicles involves the movement of carrier vesicles and requires Rab protein function. Rab proteins are also an integral part of endocytic pathways. Rab 23, also known as HSPC137, is a 237 amino acid member of the Rab family of proteins and localizes to the cytoplasmic side of the cell membrane. Rab 23 is believed to play a role in intracellular protein transportation and signal transduction mediated by small GTPases. Mutations in the gene encoding Rab 23 may result in Carpenter syndrome, also known as ACPS2 (acrocephalopolysyndactyly type 2), a condition characterized by obesity, cardiac defects, polysyndactyly and craniosynostosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

RAB23 regulates musculoskeletal development and patterning.

Frontiers in cell and developmental biology

Hasan MR,Koskenranta A,Alakurtti K,Takatalo M,Rice DP

Tue Mar 14 00:00:00 UTC 2023

Silencing of Rab23 by siRNA inhibits ultraviolet B-induced melanogenesis via downregulation of PKA/CREB/MITF.

Experimental dermatology

Wei X,Huang M,Yang Y,Liu Y,Chi S,Li C

Mon Aug 01 00:00:00 UTC 2022

Silencing of Rab23 by siRNA inhibits ultraviolet B-induced melanogenesis via downregulation of PKA/CREB/MITF.

Experimental dermatology

Wei X,Huang M,Yang Y,Liu Y,Chi S,Li C

Mon Aug 01 00:00:00 UTC 2022

Silencing of Rab23 by siRNA inhibits ultraviolet B-induced melanogenesis via downregulation of PKA/CREB/MITF.

Experimental dermatology

Wei X,Huang M,Yang Y,Liu Y,Chi S,Li C

Mon Aug 01 00:00:00 UTC 2022

Silencing of Rab23 by siRNA inhibits ultraviolet B-induced melanogenesis via downregulation of PKA/CREB/MITF.

Experimental dermatology

Wei X,Huang M,Yang Y,Liu Y,Chi S,Li C

Mon Aug 01 00:00:00 UTC 2022

RAB23 coordinates early osteogenesis by repressing FGF10-pERK1/2 and GLI1.

eLife

Hasan MR,Takatalo M,Ma H,Rice R,Mustonen T,Rice DP

Tue Jul 14 00:00:00 UTC 2020

RAB23 coordinates early osteogenesis by repressing FGF10-pERK1/2 and GLI1.

eLife

Hasan MR,Takatalo M,Ma H,Rice R,Mustonen T,Rice DP

Tue Jul 14 00:00:00 UTC 2020

Downregulation of Rab23 inhibits proliferation, invasion, and metastasis of human ovarian cancer.

The international journal of biochemistry & cell biology

Gao L,Zheng M,Guo Q,Nie X,Li X,Hao Y,Liu J,Zhu L,Lin B

Fri Nov 01 00:00:00 UTC 2019

Downregulation of Rab23 inhibits proliferation, invasion, and metastasis of human ovarian cancer.

The international journal of biochemistry & cell biology

Gao L,Zheng M,Guo Q,Nie X,Li X,Hao Y,Liu J,Zhu L,Lin B

Fri Nov 01 00:00:00 UTC 2019

Rab23/Kif17 regulate meiotic progression in oocytes by modulating tubulin acetylation and actin dynamics.

Development (Cambridge, England)

Wang HH,Zhang Y,Tang F,Pan MH,Wan X,Li XH,Sun SC

Mon Feb 04 00:00:00 UTC 2019

Rab23/Kif17 regulate meiotic progression in oocytes by modulating tubulin acetylation and actin dynamics.

Development (Cambridge, England)

Wang HH,Zhang Y,Tang F,Pan MH,Wan X,Li XH,Sun SC

Mon Feb 04 00:00:00 UTC 2019

Planar Cell Polarity Effector Proteins Inturned and Fuzzy Form a Rab23 GEF Complex.

Current biology : CB

Gerondopoulos A,Strutt H,Stevenson NL,Sobajima T,Levine TP,Stephens DJ,Strutt D,Barr FA

Mon Oct 07 00:00:00 UTC 2019

Planar Cell Polarity Effector Proteins Inturned and Fuzzy Form a Rab23 GEF Complex.

Current biology : CB

Gerondopoulos A,Strutt H,Stevenson NL,Sobajima T,Levine TP,Stephens DJ,Strutt D,Barr FA

Mon Oct 07 00:00:00 UTC 2019

Planar Cell Polarity Effector Proteins Inturned and Fuzzy Form a Rab23 GEF Complex.

Current biology : CB

Gerondopoulos A,Strutt H,Stevenson NL,Sobajima T,Levine TP,Stephens DJ,Strutt D,Barr FA

Mon Oct 07 00:00:00 UTC 2019

Planar Cell Polarity Effector Proteins Inturned and Fuzzy Form a Rab23 GEF Complex.

Current biology : CB

Gerondopoulos A,Strutt H,Stevenson NL,Sobajima T,Levine TP,Stephens DJ,Strutt D,Barr FA

Mon Oct 07 00:00:00 UTC 2019

miR-338-3p targets RAB23 and suppresses tumorigenicity of prostate cancer cells.

American journal of cancer research

Wang Y,Qin H

Sun Apr 10 00:00:00 UTC 2022

miR-338-3p targets RAB23 and suppresses tumorigenicity of prostate cancer cells.

American journal of cancer research

Wang Y,Qin H

Sun Apr 10 00:00:00 UTC 2022

miR-338-3p targets RAB23 and suppresses tumorigenicity of prostate cancer cells.

American journal of cancer research

Wang Y,Qin H

Sun Apr 10 00:00:00 UTC 2022

miR-338-3p targets RAB23 and suppresses tumorigenicity of prostate cancer cells.

American journal of cancer research

Wang Y,Qin H

Sun Apr 10 00:00:00 UTC 2022

Rab23 promotes squamous cell carcinoma cell migration and invasion via integrin β1/Rac1 pathway.

Oncotarget

Jian Q,Miao Y,Tang L,Huang M,Yang Y,Ba W,Liu Y,Chi S,Li C

Tue Feb 02 00:00:00 UTC 2016

Rab23 promotes squamous cell carcinoma cell migration and invasion via integrin β1/Rac1 pathway.

Oncotarget

Jian Q,Miao Y,Tang L,Huang M,Yang Y,Ba W,Liu Y,Chi S,Li C

Tue Feb 02 00:00:00 UTC 2016

Rab23 promotes squamous cell carcinoma cell migration and invasion via integrin β1/Rac1 pathway.

Oncotarget

Jian Q,Miao Y,Tang L,Huang M,Yang Y,Ba W,Liu Y,Chi S,Li C

Tue Feb 02 00:00:00 UTC 2016

Rab23 promotes squamous cell carcinoma cell migration and invasion via integrin β1/Rac1 pathway.

Oncotarget

Jian Q,Miao Y,Tang L,Huang M,Yang Y,Ba W,Liu Y,Chi S,Li C

Tue Feb 02 00:00:00 UTC 2016

Differential role of Rab proteins in ciliary trafficking: Rab23 regulates smoothened levels.

Journal of cell science

Boehlke C,Bashkurov M,Buescher A,Krick T,John AK,Nitschke R,Walz G,Kuehn EW

Sat May 01 00:00:00 UTC 2010

Differential role of Rab proteins in ciliary trafficking: Rab23 regulates smoothened levels.

Journal of cell science

Boehlke C,Bashkurov M,Buescher A,Krick T,John AK,Nitschke R,Walz G,Kuehn EW

Sat May 01 00:00:00 UTC 2010

Bioinformatics

Protein Aliases: DKFZp781H0695; MGC8900; open brain 2; OTTHUMP00000040021; protein open brain; RAB 23; RAB family small GTP binding protein RAB 23; rab-15; Ras-related protein Rab-23; RP3-496N17.3

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Gene Aliases: AW545388; HSPC137; opb; opb2; RAB23

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UniProt ID: (Human) Q9ULC3

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Entrez Gene ID: (Human) 51715, (Mouse) 19335, (Rat) 367242

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Function(s)

GTPase activity protein binding GTP binding nucleotide binding GDP binding

Process(es)

autophagosome assembly neural tube closure transport intracellular protein transport cellular defense response signal transduction small GTPase mediated signal transduction multicellular organism development nervous system development regulation of smoothened signaling pathway protein transport spinal cord dorsal/ventral patterning dorsal/ventral neural tube patterning Rab protein signal transduction cilium assembly embryonic digit morphogenesis negative regulation of transcription factor import into nucleus negative regulation of proteolysis craniofacial suture morphogenesis

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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Rab23 Polyclonal Antibody

Rab23 Antibody (11101-1-AP) in IHC (P)

Product Details

11101-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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