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Bioss
Rab3A+Rab3B+Rab3C+Rab3D Polyclonal Antibody
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Rab3A+Rab3B+Rab3C+Rab3D Antibody (BS-6180R) in IHC (P)
Paraformaldehyde-fixed, paraffin embedded rat heart; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with Rab3A+Rab3B+Rab3C+Rab3D Antibody Polyclonal Antibody, Unconjugated (bs-6180R) at 1:400 overnight at 4°C, followed by a conjugated second... View More
Product Details
BS-6180R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human Rab3A+Rab3B+Rab3C+Rab3D.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Rab proteins belong to the Ras small GTPase superfamily. The GTP-binding Rab3 subfamily has four known isoforms: 3A, 3B, 3C and 3D. These proteins are expressed in the highest concentration in the brain and endocrine tissues and are involved in regulated exocytosis of hormones and neurotransmitters. Specifically Rab3's are thought to play a role in presynaptic vesicle trafficking and priming.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: brain antigen RAB3B; glioblastoma overexpressed; GTP-binding protein Rab-3D; Rab3D upregulated with myeloid differentiation; RAS-associated protein RAB3A; Ras-related protein Rab-3A; Ras-related protein Rab-3B; Ras-related protein Rab-3C; Ras-related protein Rab-3D; Ras-related small GTP binding protein 3A; small GTP-binding protein Rab3C
Gene Aliases: 2610528C18Rik; 2700062I01Rik; 3110015B08Rik; 3110037E15Rik; AI850886; C130057E11Rik; D2-2; GOV; RAB16; RAB3; RAB3A; RAB3B; RAB3C; RAB3D; RAD3D
UniProt ID: (Human) P20336, (Human) P20337, (Human) Q96E17, (Human) O95716, (Rat) P63012, (Mouse) P63011, (Mouse) Q9CZT8, (Rat) Q63941, (Rat) P62824, (Mouse) P62823, (Mouse) P35276, (Rat) Q63942
Entrez Gene ID: (Human) 5864, (Human) 5865, (Human) 115827, (Human) 9545, (Rat) 25531, (Mouse) 19339, (Mouse) 69908, (Rat) 81755, (Rat) 171058, (Mouse) 67295, (Mouse) 19340, (Rat) 140665
small GTPase mediated signal transduction
protein transport
regulation of exocytosis
antigen processing and presentation
intracellular protein transport
vesicle docking involved in exocytosis
metabolic process
protein secretion
synaptic vesicle exocytosis
Rab protein signal transduction
protein localization to plasma membrane
respiratory system process
mitochondrion organization
neuromuscular synaptic transmission
axonogenesis
post-embryonic development
synaptic vesicle maturation
lung development
regulation of synaptic vesicle fusion to presynaptic membrane
positive regulation of ATPase activity
synaptic vesicle recycling
regulation of short-term neuronal synaptic plasticity
maintenance of presynaptic active zone structure
sensory perception of touch
response to electrical stimulus
positive regulation of regulated secretory pathway
transport
peptidyl-cysteine methylation
positive regulation of dopamine uptake involved in synaptic transmission
regulation of vesicle size
exocytosis
bone resorption
synaptic vesicle transport
evoked neurotransmitter secretion
regulation of long-term synaptic potentiation
neurotransmitter secretion
glutamate secretion
constitutive secretory pathway
positive regulation of exocytosis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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