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Invitrogen
Rabex-5 Polyclonal Antibody
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FIGURE: 1 / 1
Rabex-5 Antibody (PA5-148258) in ICC/IF
Immunocytochemistry analysis of Rabex-5 in U251MG cells. Samples were incubated with Rabex-5 polyclonal antibody (Product # PA5-148258) using a dilution of 1:200 at 4°C overnight followed by Alexa Fluor 488-conjugated Goat Anti-rabbit IgG secondary antibody (green). Cells were fixed with 4% PFA, permeabilized with 0.1% Triton X-100 in PBS, and blocked with 10% serum. Counterstained with DAPI (blue). Positive staining was localized to Cytoplasm.
Product Details
PA5-148258
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
E. coli-derived Human RABGEF1 fragment
Conjugate
Form
Liquid
Concentration
100 µg/mL
Purification
Antigen affinity chromatography, Protein A
Storage buffer
PBS, pH 7
Contains
0.03% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_3247427
Target Information
RABGEF1 forms a complex with rabaptin-5 (RABPT5) that is required for endocytic membrane fusion, and it serves as a specific guanine nucleotide exchange factor (GEF) for RAB5.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: RAB guanine nucleotide exchange factor (GEF) 1; Rab5 GDP/GTP exchange factor; Rabaptin-5-associated exchange factor for Rab5; Rabex-5; RAP1
Gene Aliases: rabex-5; RABEX5; RABGEF1; RAP1
UniProt ID: (Human) Q9UJ41
Entrez Gene ID: (Human) 27342
negative regulation of protein phosphorylation
negative regulation of leukocyte migration
protein targeting to membrane
endocytosis
protein ubiquitination
negative regulation of mast cell degranulation
positive regulation of GTPase activity
negative regulation of Ras protein signal transduction
negative regulation of receptor-mediated endocytosis
negative regulation of inflammatory response
regulation of Fc receptor mediated stimulatory signaling pathway
negative regulation of interleukin-6 secretion
negative regulation of Kit signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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