Invitrogen

Reelin Polyclonal Antibody

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Datasheet
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Datasheet
Protocols
Questions & Answers

Product Details

PA5-120595

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 50-190 of human RELN (NP_005036.2).
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.28 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.05% ProClin 300

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2914167

Product Specific Information

Positive test controls include: U-87MG, C6, LO2, HepG2.

Immunogen sequence: KISTKNPDFL KDDFEGQLES DRFLLMSGGK PSRKCGILSS GNNLFFNEDG LRMLMTRDLD LSHARFVQFF MRLGCGKGVP DPRSQPVLLQ YSLNGGLSWS LLQEFLFSNS SNVGRYIALE IPLKARSGST RLRWWQPSEN GHFYSPWVID QILIGGNISG N

Target Information

Reelin in an extracellular matrix serine protease that plays a role in layering of neurons in the cerebral cortex and cerebellum. Regulates microtubule function in neurons and neuronal migration. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion. Binding to the extracellular domains of lipoprotein receptors VLDLR and LRP8/APOER2 induces tyrosine phosphorylation of DAB1 and modulation of TAU phosphorylation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: extracellular matrix serine protease; Reeler protein; Reelin

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Gene Aliases: ETL7; LIS2; PRO1598; Reelen; reeler; RELN; RL

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UniProt ID: (Human) P78509, (Mouse) Q60841, (Rat) P58751

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Entrez Gene ID: (Human) 5649, (Mouse) 19699, (Rat) 24718

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Function(s)
protein serine/threonine/tyrosine kinase activity serine-type peptidase activity metal ion binding lipoprotein particle receptor binding very-low-density lipoprotein particle receptor binding protein binding peptidase activity hydrolase activity molecular_function
Process(es)
cell morphogenesis involved in differentiation neuron migration proteolysis cell adhesion multicellular organism development axon guidance central nervous system development brain development long-term memory locomotory behavior associative learning glial cell differentiation regulation of gene expression positive regulation of neuron projection development positive regulation of phosphatidylinositol 3-kinase signaling dendrite development cell migration peptidyl-tyrosine phosphorylation spinal cord patterning dentate gyrus development hippocampus development cerebral cortex tangential migration layer formation in cerebral cortex cerebral cortex development forebrain development positive regulation of TOR signaling positive regulation of CREB transcription factor activity protein localization to synapse reelin-mediated signaling pathway thyroid hormone metabolic process positive regulation of protein kinase activity response to pain positive regulation of peptidyl-tyrosine phosphorylation regulation of behavior modulation of synaptic transmission positive regulation of small GTPase mediated signal transduction positive regulation of synaptic transmission, glutamatergic positive regulation of dendritic spine morphogenesis positive regulation of protein tyrosine kinase activity positive regulation of synapse maturation postsynaptic density assembly NMDA glutamate receptor clustering postsynaptic density protein 95 clustering receptor localization to synapse lateral motor column neuron migration positive regulation of long-term synaptic potentiation positive regulation of lateral motor column neuron migration regulation of N-methyl-D-aspartate selective glutamate receptor activity positive regulation of excitatory postsynaptic potential positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity ventral spinal cord development long-term synaptic potentiation midgut development memory response to mechanical stimulus response to toxic substance response to hormone response to lithium ion response to organic cyclic compound response to insecticide orbitofrontal cortex development hypothalamus development response to progesterone social behavior response to drug response to amino acid response to ethanol response to axon injury response to corticosterone response to electrical stimulus response to fatty acid cellular response to dexamethasone stimulus
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