Invitrogen

Reelin Recombinant Rabbit Monoclonal Antibody (JA63-13)

View all (10) Reelin antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

MA5-32723

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-
Product Specifications

Species Reactivity

Human, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

JA63-13

Immunogen

Synthetic peptide within Human Reelin aa 3248-3297
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

TBS, pH 7.4, with 40% Glycerol, 0.05% BSA

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2810000

Product Specific Information

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

Target Information

Reelin in an extracellular matrix serine protease that plays a role in layering of neurons in the cerebral cortex and cerebellum. Regulates microtubule function in neurons and neuronal migration. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion. Binding to the extracellular domains of lipoprotein receptors VLDLR and LRP8/APOER2 induces tyrosine phosphorylation of DAB1 and modulation of TAU phosphorylation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Reelin

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Gene Aliases: ETL7; LIS2; PRO1598; Reelen; reeler; RELN; RL

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UniProt ID: (Human) P78509, (Rat) P58751

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Entrez Gene ID: (Human) 5649, (Rat) 24718

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Function(s)
protein serine/threonine/tyrosine kinase activity serine-type peptidase activity metal ion binding lipoprotein particle receptor binding very-low-density lipoprotein particle receptor binding molecular_function
Process(es)
cell morphogenesis involved in differentiation neuron migration proteolysis cell adhesion axon guidance central nervous system development brain development long-term memory associative learning glial cell differentiation positive regulation of neuron projection development positive regulation of phosphatidylinositol 3-kinase signaling dendrite development peptidyl-tyrosine phosphorylation spinal cord patterning ventral spinal cord development hippocampus development cerebral cortex tangential migration layer formation in cerebral cortex positive regulation of TOR signaling positive regulation of CREB transcription factor activity reelin-mediated signaling pathway positive regulation of protein kinase activity response to pain positive regulation of peptidyl-tyrosine phosphorylation regulation of behavior modulation of synaptic transmission positive regulation of small GTPase mediated signal transduction positive regulation of synaptic transmission, glutamatergic long-term synaptic potentiation positive regulation of dendritic spine morphogenesis positive regulation of protein tyrosine kinase activity positive regulation of synapse maturation NMDA glutamate receptor clustering postsynaptic density protein 95 clustering receptor localization to synapse lateral motor column neuron migration positive regulation of long-term synaptic potentiation positive regulation of lateral motor column neuron migration regulation of N-methyl-D-aspartate selective glutamate receptor activity positive regulation of excitatory postsynaptic potential positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity midgut development memory locomotory behavior response to mechanical stimulus response to toxic substance response to hormone response to lithium ion regulation of gene expression response to organic cyclic compound cell migration response to insecticide dentate gyrus development orbitofrontal cortex development hypothalamus development cerebral cortex development forebrain development response to progesterone social behavior protein localization to synapse thyroid hormone metabolic process response to drug response to amino acid response to ethanol response to axon injury response to corticosterone response to electrical stimulus response to fatty acid cellular response to dexamethasone stimulus
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