Alomone Labs, LTD

Ret (extracellular) Polyclonal Antibody

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Datasheet
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Datasheet
Protocols
Questions & Answers

Product Details

ANT-025-200UL

Applications
Tested Dilution
Publications

Western Blot (WB)

1:200
-

Immunohistochemistry (Frozen) (IHC (F))

1:50
-

Immunocytochemistry (ICC/IF)

1:25
-

Flow Cytometry (Flow)

5 µg
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

CEWRQGDGKGITR, corresponding to amino acid residues 541-553 of human Ret, Extracellular, N-terminus
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.8 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.4, with 1% BSA

Contains

0.05% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Target Information

The receptor tyrosine kinase RET is a member of the cadherin superfamily. RET plays a crucial role in neural crest development, and can undergo oncogenic activation by cytogenetic rearrangement. RET transduce signals for cell growth and differentiation. Mutations in the RET gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been found for the RET gene. Additional transcript variants have been described for RET but their biological validity has not been confirmed.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Cadherin family member 12; Cadherin family member 12 (CDHF12); Cadherin related family member 16 (CDHR16); cadherin-related family member 16; CUX1/RET fusion; EC 2.7.10.1; ELKS; Hydroxyaryl protein kinase; hydroxyaryl-protein kinase; kinase Ret; Multiple endocrine neoplasia and medullary thyroid carcinoma 1; Oncogene RET; OTTHUMP00000216967; Proto-oncogene c-Ret; Proto-oncogene tyrosine-protein kinase receptor Ret; rearranged during transfection; receptor tyrosine kinase; RET ELE1; Ret gene for receptor tyrosin; ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease); Ret proto-oncogene (multiple endocrine neoplasia MEN2A MEN2B and medullary thyroid carcinoma 1 Hirschsprung disease); RET receptor tyrosine kinase; RET transforming sequence

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Gene Aliases: c-Ret; CDHF12; CDHR16; HSCR1; MEN2A; MEN2B; MTC1; PTC; RET; RET-ELE1; RET51; RET9

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UniProt ID: (Human) P07949, (Mouse) P35546, (Rat) G3V9H8

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Entrez Gene ID: (Human) 5979, (Mouse) 19713, (Rat) 24716

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Function(s)
protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity receptor activity Ras guanyl-nucleotide exchange factor activity calcium ion binding protein binding ATP binding nucleotide binding protein kinase activity kinase activity transferase activity transferase activity, transferring phosphorus-containing groups molecular_function
Process(es)
MAPK cascade ureteric bud development neural crest cell migration embryonic epithelial tube formation protein phosphorylation activation of cysteine-type endopeptidase activity involved in apoptotic process cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules neuron cell-cell adhesion signal transduction transmembrane receptor protein tyrosine kinase signaling pathway nervous system development anatomical structure morphogenesis positive regulation of gene expression positive regulation of neuron projection development positive regulation of neuron maturation phosphorylation peptidyl-tyrosine phosphorylation regulation of cell adhesion neuron differentiation positive regulation of cell migration membrane protein proteolysis positive regulation of cell adhesion mediated by integrin ureter maturation neuron maturation positive regulation of cell size positive regulation of transcription, DNA-templated response to pain enteric nervous system development regulation of axonogenesis innervation Peyer's patch morphogenesis cellular response to retinoic acid positive regulation of metanephric glomerulus development positive regulation of extrinsic apoptotic signaling pathway in absence of ligand posterior midgut development response to drug positive regulation of GTPase activity retina development in camera-type eye lymphocyte migration into lymphoid organs positive regulation of serine phosphorylation of STAT3 protein
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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