Invitrogen

RhoA/RhoC Monoclonal Antibody (1B3-4A10)

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Datasheet
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Datasheet
Protocols
Questions & Answers

Product Details

MA1-123

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,500
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500
-

Immunocytochemistry (ICC/IF)

5 µg/mL
-

Immunoprecipitation (IP)

2 µg
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgG

Class

Monoclonal

Type

Antibody

Clone

1B3-4A10

Immunogen

Full-length human recombinant RhoA protein.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

PBS with 30% glycerol, 1mg/mL BSA

Contains

0.05% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2536831

Product Specific Information

MA1-123 detects GTPases RhoA and RhoC, but does not react with RhoB.

MA1-123 has been successfully used in Western blot, immunofluorescence, IHC (P) and immunoprecipitation applications with human and mouse samples.

Target Information

RhoA is described as a small GTPase protein that regulates the actin cytoskeleton in the formation of stress fibers. RhoA is also included in the related proteins of the Ras superfamily, which involves proteins in the regulation and timing of cell division.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Aplysia ras-related homolog 12; aplysia ras-related homolog 9 (RhoC); aplysia ras-related homolog A; aplysia ras-related homolog A1; aplysia ras-related homolog A2; h12; h9; oncogene RHO H12; oncogene RHO H9; plysia ras-related homolog A2; Ras family member A; ras homolog 9 (RhoC); ras homolog A1; ras homolog A2; ras homolog gene family, member A; ras homolog gene family, member A1; ras homolog gene family, member A2; ras homolog gene family, member C; RAS-related homolog 9; Rho; Rho cDNA clone 12; Rho cDNA clone 9; Rho family GTPase; Rho-related GTP-binding protein RhoC; rhoC GTPase; SIG-61; Silica-induced gene 61 protein; small GTP binding protein RhoA; small GTP binding protein RhoC; Transforming protein RhoA

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Gene Aliases: AI324259; ARH12; ARH9; ARHA; Arha1; Arha2; ARHC; H9; RHO12; RHOA; RHOC; RHOH12; RHOH9

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UniProt ID: (Human) P61586, (Human) P08134, (Rat) P61589, (Mouse) Q9QUI0, (Mouse) Q62159

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Entrez Gene ID: (Human) 387, (Human) 389, (Rat) 117273, (Mouse) 11848, (Mouse) 11853, (Rat) 295342

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Function(s)
GTPase activity protein binding GTP binding myosin binding signal transducer activity GDP binding protein domain specific binding Rho GDP-dissociation inhibitor binding nucleotide binding
Process(es)
cytokinesis small GTPase mediated signal transduction positive regulation of I-kappaB kinase/NF-kappaB signaling apical junction assembly wound healing, spreading of cells regulation of small GTPase mediated signal transduction positive regulation of lipase activity skeletal muscle satellite cell migration signal transduction cell morphogenesis response to hypoxia regulation of transcription from RNA polymerase II promoter cytoskeleton organization cell adhesion cell-matrix adhesion skeletal muscle tissue development regulation of actin polymerization or depolymerization metabolic process response to mechanical stimulus response to glucose regulation of neuron projection development substantia nigra development cerebral cortex cell migration forebrain radial glial cell differentiation actin cytoskeleton organization cell differentiation positive regulation of cell growth regulation of cell migration positive regulation of cell migration androgen receptor signaling pathway positive regulation of actin filament polymerization stress-activated protein kinase signaling cascade positive regulation of cytokinesis negative regulation of intracellular steroid hormone receptor signaling pathway regulation of osteoblast proliferation cleavage furrow formation apolipoprotein A-I-mediated signaling pathway response to drug negative regulation of I-kappaB kinase/NF-kappaB signaling stress fiber assembly response to amino acid positive regulation of cysteine-type endopeptidase activity involved in apoptotic process negative regulation of neuron apoptotic process positive regulation of neuron apoptotic process ossification involved in bone maturation response to ethanol negative regulation of neuron differentiation positive regulation of neuron differentiation positive regulation of translation positive regulation of cell adhesion positive regulation of vasoconstriction positive regulation of smooth muscle contraction neuron projection morphogenesis regulation of dendrite development negative chemotaxis response to glucocorticoid positive regulation of stress fiber assembly regulation of calcium ion transport negative regulation of cell death trabecula morphogenesis cellular response to progesterone stimulus positive regulation of podosome assembly mitotic spindle assembly regulation of neural precursor cell proliferation cell cycle integrin-mediated signaling pathway Rho protein signal transduction GTP metabolic process cell division transforming growth factor beta receptor signaling pathway viral process cell migration platelet activation actin cytoskeleton reorganization regulation of actin cytoskeleton organization Roundabout signaling pathway positive regulation of NF-kappaB import into nucleus endothelial cell migration vascular endothelial growth factor receptor signaling pathway ephrin receptor signaling pathway phosphatidylinositol-mediated signaling negative regulation of axonogenesis positive regulation of axonogenesis Wnt signaling pathway, planar cell polarity pathway positive regulation of protein serine/threonine kinase activity negative regulation of cell migration involved in sprouting angiogenesis endothelial tube lumen extension mitotic cleavage furrow formation regulation of cell motility
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