Invitrogen

Rhodopsin Monoclonal Antibody (1D4)

1 Published Figure

4 References

View all (27) Rhodopsin antibodies

Datasheet

Protocols

Questions & Answers

Datasheet

Protocols

Questions & Answers

Antibody Testing Data (1)
Published Figures (1)

Rhodopsin Antibody in Immunohistochemistry (IHC)

FIGURE: 1 / 2

Rhodopsin Antibody (P21940) in IHC

Immunohistochemical staining of a mouse retinal section showing specific immunolabeling of the rhodopsin protein in the rod sperules. Photo courtesy of Mary Raven, University of California, Santa Barbara, CA.

Rhodopsin Antibody in Immunohistochemistry (Frozen) (IHC (F))

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Product Details

P21940

Applications

Tested Dilution

Publications

Western Blot (WB)

Assay-dependent

View 2 publications 2 publications

Immunohistochemistry (IHC)

Assay-dependent

View 1 publication 1 publication

Immunohistochemistry (Frozen) (IHC (F))

View 1 publication 1 publication

Product Specifications

Species Reactivity

Bovine, Human, Mouse, Rat

Published species

Human, Mouse, Pig

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

1D4

Immunogen

Bovine rhodopsin.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Purification

purified

Storage buffer

HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol

Contains

no preservative

Storage conditions

Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

AB_2539827

Target Information

Visual pigments such as rhodopsin and porphyropsin are light-absorbing molecules that mediate vision. Rhodopsin consists of an apoprotein, opsin, covalently linked to 11-cis-retinal. This receptor is coupled to the activation of phospholipase C. Porphyropsin consists of opsin covalently linked to 11-cis 3,4-didehydroretinal.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Novel AAV capsids for intravitreal gene therapy of photoreceptor disorders.

EMBO molecular medicine

Pavlou M,Schön C,Occelli LM,Rossi A,Meumann N,Boyd RF,Bartoe JT,Siedlecki J,Gerhardt MJ,Babutzka S,Bogedein J,Wagner JE,Priglinger SG,Biel M,Petersen-Jones SM,Büning H,Michalakis S

P21940 was used in Immunohistochemistry-immunofluorescence to report the development of novel engineered rAAV vectors that enable efficient targeting of photoreceptors via less invasive intravitreal administration.

Fri Apr 09 00:00:00 UTC 2021

Human nonvisual opsin 3 regulates pigmentation of epidermal melanocytes through functional interaction with melanocortin 1 receptor.

Proceedings of the National Academy of Sciences of the United States of America

Ozdeslik RN,Olinski LE,Trieu MM,Oprian DD,Oancea E

P21940 was used in Western Blot to reveal a light-independent function for the poorly characterized OPN3 and a pathway that greatly expands our understanding of melanocyte and skin physiology.

Tue Jun 04 00:00:00 UTC 2019

A G Protein-Coupled Receptor Dimerization Interface in Human Cone Opsins.

Biochemistry

Jastrzebska B,Comar WD,Kaliszewski MJ,Skinner KC,Torcasio MH,Esway AS,Jin H,Palczewski K,Smith AW

P21940 was used in western blot to study the dimerization affinity and binding interface of human cone opsins

Tue Jan 10 00:00:00 UTC 2017

Progression of Pro23His Retinopathy in a Miniature Swine Model of Retinitis Pigmentosa.

Translational vision science & technology

Scott PA,de Castro JP,DeMarco PJ,Ross JW,Njoka J,Walters E,Prather RS,McCall MA,Kaplan HJ

P21940 was used in immunohistochemistry - frozen section to examine pathogenesis in Filial 1 progeny of a transgenic founder mini swine exhibiting severe Pro23His retinopathy

Wed Mar 01 00:00:00 UTC 2017

Bioinformatics

Protein Aliases: L opsin; Long Wavelength Sensitive opsin; LWS opsin; MGC138309; MGC138311; OPN 2; opsin 2; opsin 2, rod pigment; Opsin-2; Red Opsin; Rhodopsin; rhodopsin (opsin 2, rod pigment) (retinitis pigmentosa 4, autosomal dominant); Rhodopsin (retinitis pigmentosa 4, autosomal dominant); Rod Opsin; RP 4

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Gene Aliases: BOS_21149; CSNBAD1; Noerg1; OPN2; Ops; RHO; RP4

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UniProt ID: (Bovine) P02699, (Human) P08100, (Rat) P51489, (Mouse) P15409

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Entrez Gene ID: (Bovine) 509933, (Human) 6010, (Rat) 24717, (Mouse) 212541

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Function(s)

G-protein coupled receptor activity guanyl-nucleotide exchange factor activity protein binding photoreceptor activity metal ion binding G-protein coupled photoreceptor activity retinal binding spectrin binding signal transducer activity

Process(es)

protein phosphorylation visual perception phototransduction protein-chromophore linkage retina development in camera-type eye cellular response to light stimulus retinoid metabolic process G-protein coupled receptor signaling pathway phototransduction, visible light red, far-red light phototransduction absorption of visible light rhodopsin mediated signaling pathway regulation of rhodopsin mediated signaling pathway photoreceptor cell maintenance response to light stimulus detection of light stimulus sensory perception of light stimulus signal transduction response to stimulus

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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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Rhodopsin Monoclonal Antibody (1D4)

Rhodopsin Antibody (P21940) in IHC

Product Details

P21940

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Frozen) (IHC (F))

Species Reactivity

Published species

Host/Isotype

Class

Type

Clone

Immunogen

Conjugate

Form

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Target Information

Bioinformatics

Performance Guarantee

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