Invitrogen

Rhodopsin Monoclonal Antibody (RET-P1)

Rhodopsin Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Rhodopsin Antibody (MA5-11741) in IHC (P)

Formalin-fixed, paraffin-embedded human brain stained with Rhodopsin antibody using peroxidase-conjugate and AEC chromogen. Note cytoplasmic staining of neurons.

Rhodopsin Antibody in Immunohistochemistry (IHC)

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Product Details

MA5-11741

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000

View 1 publication 1 publication

Immunohistochemistry (IHC)

View 9 publications 9 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

View 1 publication 1 publication

Immunocytochemistry (ICC/IF)

View 2 publications 2 publications

Flow Cytometry (Flow)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Dog, Human, Mouse, Rat

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

RET-P1

Immunogen

Membrane preparation from adult rat retina

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Protein G

Storage buffer

PBS, pH 7.4, with 0.2% BSA

Contains

0.09% sodium azide

Storage conditions

4°C

Shipping conditions

Ambient (domestic); Wet ice (international)

AB_10980983

Product Specific Information

MA5-11741 targets Rhodopsin in immunofluorescence, immunohistochemistry (paraffin) and Western blot applications and shows reactivity with human, mouse, and rat samples.

The MA5-11741 immunogen is membrane preparation from adult rat retina.

Target Information

Visual pigments such as rhodopsin and porphyropsin are light-absorbing molecules that mediate vision. Rhodopsin consists of an apoprotein, opsin, covalently linked to 11-cis-retinal. This receptor is coupled to the activation of phospholipase C. Porphyropsin consists of opsin covalently linked to 11-cis 3,4-didehydroretinal.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Exosome-mediated inhibition of microRNA-449a promotes the amplification of mouse retinal progenitor cells and enhances their transplantation in retinal degeneration mouse models.

Molecular therapy. Nucleic acids

Guo CJ,Cao XL,Zhang YF,Yue KY,Han J,Yan H,Han H,Zheng MH

MA5-11741 was used in Immunocytochemistry to show that exosome-miR-449a inhibitor can effectively promote the expansion of RPCs in vitro and enhance transplanted RPCs survival in vivo, which might provide a novel intervention strategy for retinal degenerations in the future.

Tue Mar 14 00:00:00 UTC 2023

A Splicing Mutation in Slc4a5 Results in Retinal Detachment and Retinal Pigment Epithelium Dysfunction.

International journal of molecular sciences

Collin GB,Shi L,Yu M,Akturk N,Charette JR,Hyde LF,Weatherly SM,Pera MF,Naggert JK,Peachey NS,Nishina PM,Krebs MP

Published figure using Rhodopsin monoclonal antibody (Product # MA5-11741) in Immunohistochemistry

Thu Feb 17 00:00:00 UTC 2022

Compartmentalized microfluidic device for in vitro co-culture of retinal cells.

Biotechnology journal

Jahagirdar D,Yadav S,Gore M,Korpale V,Mathpati CS,Chidambaram S,Majumder A,Jain R,Dandekar P

MA5-11741 was used in Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry to prove the functionality of the retinal coculture, which may be used as an appropriate perfusion-based, preclinical tool for the evaluation of novel retinal drugs and delivery systems.

Thu Sep 01 00:00:00 UTC 2022

Rai1 frees mice from the repression of active wake behaviors by light.

eLife

Diessler S,Kostic C,Arsenijevic Y,Kawasaki A,Franken P

Published figure using Rhodopsin monoclonal antibody (Product # MA5-11741) in Immunofluorescence

Fri May 26 00:00:00 UTC 2017

Retinal Pigment Epithelium Atrophy 1 (rpea1): A New Mouse Model With Retinal Detachment Caused by a Disruption of Protein Kinase C, θ.

Investigative ophthalmology & visual science

Ji X,Liu Y,Hurd R,Wang J,Fitzmaurice B,Nishina PM,Chang B

MA5-11741 was used in immunohistochemistry - paraffin section to utilize a novel mouse model with retinal detachment caused by a disruption of protein kinase C, theta, to study retinal pigment epithelium atrophy 1 (rpea1)

Tue Mar 01 00:00:00 UTC 2016

Effect of purified murine NGF on isolated photoreceptors of a rodent developing retinitis pigmentosa.

PloS one

Rocco ML,Balzamino BO,Petrocchi Passeri P,Micera A,Aloe L

MA5-11741 was used in flow cytometry and immunocytochemistry to analyze developing retinitis pigmentosa in a rodent after purified murine NGF on isolated photoreceptors

Wed Mar 30 00:00:00 UTC 2016

Proliferation of the ciliary epithelium with retinal neuronal and photoreceptor cell differentiation in human eyes with retinal detachment and proliferative vitreoretinopathy.

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie

Ducournau Y,Boscher C,Adelman RA,Guillaubey C,Schmidt-Morand D,Mosnier JF,Ducournau D

MA5-11741 was used in immunohistochemistry to investigate the trans-differentiating capacity of ciliary epithelial cells in human eyes

Thu Mar 01 00:00:00 UTC 2012

Identification and functional analysis of the vision-specific BBS3 (ARL6) long isoform.

PLoS genetics

Pretorius PR,Baye LM,Nishimura DY,Searby CC,Bugge K,Yang B,Mullins RF,Stone EM,Sheffield VC,Slusarski DC

MA5-11741 was used in immunohistochemistry to study the function of the vision-specific BBS3 (ARL6) long isoform

Fri Mar 19 00:00:00 UTC 2010

Characterization of a canine model of autosomal recessive retinitis pigmentosa due to a PDE6A mutation.

Investigative ophthalmology & visual science

Tuntivanich N,Pittler SJ,Fischer AJ,Omar G,Kiupel M,Weber A,Yao S,Steibel JP,Khan NW,Petersen-Jones SM

MA5-11741 was used in immunohistochemistry to characterize a canine model of autosomal recessive retinitis pigmentosa

Sun Feb 01 00:00:00 UTC 2009

A Critical role for Bim in retinal ganglion cell death.

Journal of neurochemistry

McKernan DP,Cotter TG

MA5-11741 was used in western blot to study the role of Bim in retinal ganglion cell death

Wed Aug 01 00:00:00 UTC 2007

Retinal incorporation and differentiation of neural precursors derived from human embryonic stem cells.

Stem cells (Dayton, Ohio)

Banin E,Obolensky A,Idelson M,Hemo I,Reinhardtz E,Pikarsky E,Ben-Hur T,Reubinoff B

MA5-11741 was used in immunohistochemistry to investigate the differentiation of human embryonic stem cells into retinal cells

Wed Feb 01 00:00:00 UTC 2006

Conversion of mammalian Müller glial cells into a neuronal lineage by in vitro aggregate-culture.

Biochemical and biophysical research communications

Kubota A,Nishida K,Nakashima K,Tano Y

MA5-11741 was used in immunohistochemistry to study the conversion of mammalian Muller glial cells to neuronal cells using in vitro aggregate-culture

Fri Dec 15 00:00:00 UTC 2006

Detailed histopathologic characterization of the retinopathy, globe enlarged (rge) chick phenotype.

Molecular vision

Montiani-Ferreira F,Fischer A,Cernuda-Cernuda R,Kiupel M,DeGrip WJ,Sherry D,Cho SS,Shaw GC,Evans MG,Hocking PM,Petersen-Jones SM

MA5-11741 was used in immunohistochemistry to characterize the histopathologic features of retinopathy globe enlarged in chicks

Thu Jan 13 00:00:00 UTC 2005

Late development of vitelliform lesions and flecks in a patient with best disease: clinicopathologic correlation.

Archives of ophthalmology (Chicago, Ill. : 1960)

Mullins RF,Oh KT,Heffron E,Hageman GS,Stone EM

MA5-11741 was used in immunohistochemistry to report a clinical case of Best disease in a senior

Tue Nov 01 00:00:00 UTC 2005

Bioinformatics

Protein Aliases: L opsin; Long Wavelength Sensitive opsin; LWS opsin; MGC138309; MGC138311; OPN 2; opsin 2; opsin 2, rod pigment; Opsin-2; Red Opsin; Rhodopsin; Rhodopsin (retinitis pigmentosa 4, autosomal dominant); Rod Opsin; RP 4

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Gene Aliases: CSNBAD1; Noerg1; OPN2; Ops; RHO; RP4

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UniProt ID: (Human) P08100, (Rat) P51489, (Mouse) P15409

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Entrez Gene ID: (Human) 6010, (Rat) 24717, (Mouse) 212541

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Function(s)

G-protein coupled receptor activity protein binding G-protein coupled photoreceptor activity retinal binding metal ion binding photoreceptor activity spectrin binding signal transducer activity

Process(es)

retinoid metabolic process protein phosphorylation G-protein coupled receptor signaling pathway visual perception phototransduction, visible light red, far-red light phototransduction absorption of visible light rhodopsin mediated signaling pathway protein-chromophore linkage regulation of rhodopsin mediated signaling pathway photoreceptor cell maintenance retina development in camera-type eye phototransduction response to light stimulus detection of light stimulus sensory perception of light stimulus cellular response to light stimulus signal transduction response to stimulus

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Rhodopsin Monoclonal Antibody (RET-P1)

Rhodopsin Antibody (MA5-11741) in IHC (P)

Product Details

MA5-11741

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Species Reactivity

Published species

Host/Isotype

Class

Type

Clone

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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