Proteintech

RtcB Polyclonal Antibody

RtcB Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 7

RtcB Antibody (19809-1-AP) in ICC/IF

Immunofluorescent analysis of HeLa cells using 19809-1-AP (RtcB-Specific antibody) at dilution of 1:25 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

RtcB Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

19809-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:4,000

View 4 publications 4 publications

Immunocytochemistry (ICC/IF)

1:10-1:100

Immunoprecipitation (IP)

0.5-4.0 µg

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

RtcB-Specific Fusion Protein Ag13836 (159-505 aa encoded by BC000151)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.18 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody specifically recognizes endogenous RTCB protein.

Immunogen sequence: GVIPMNAKD LEEALEMGVD WSLREGYAWA EDKEHCEEYG RMLQADPNKV SARAKKRGLP QLGTLGAGNH YAEIQVVDEI FNEYAAKKMG IDHKGQVCVM IHSGSRGLGH QVATDALVAM EKAMKRDKII VNDRQLACAR IASPEGQDYL KGMAAAGNYA WVNRSSMTFL TRQAFAKVFN TTPDDFDLHV IYDVSHNIAK VEQHVVDGKE RTLLVHRKGS TRAFPPHHPL IAVDYQLTGQ PVLIGGTMGT CSYVLTGTEQ GMTETFGTTC HGAGRALSRA KSRRNLDFQD VLDKLADMGI AIRVASPKLV MEEAPESYKN VTDVVNTCHD AGISKKAIKL RPIAVIKG (159-505 aa encoded by BC000151)

Target Information

The function of this protein remains unknown.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Stress-induced tyrosine phosphorylation of RtcB modulates IRE1 activity and signaling outputs.

Life science alliance

Papaioannou A,Centonze F,Metais A,Maurel M,Negroni L,Gonzalez-Quiroz M,Mahdizadeh SJ,Svensson G,Zare E,Blondel A,Koong AC,Hetz C,Pedeux R,Tremblay ML,Eriksson LA,Chevet E

Sun May 01 00:00:00 UTC 2022

ERα is an RNA-binding protein sustaining tumor cell survival and drug resistance.

Cell

Xu Y,Huangyang P,Wang Y,Xue L,Devericks E,Nguyen HG,Yu X,Oses-Prieto JA,Burlingame AL,Miglani S,Goodarzi H,Ruggero D

Thu Sep 30 00:00:00 UTC 2021

Reprogramming of microRNA expression via E2F1 downregulation promotes Salmonella infection both in infected and bystander cells.

Nature communications

Aguilar C,Costa S,Maudet C,Vivek-Ananth RP,Zaldívar-López S,Garrido JJ,Samal A,Mano M,Eulalio A

Mon Jun 07 00:00:00 UTC 2021

The cyclic phosphodiesterase CNP and RNA cyclase RtcA fine-tune noncanonical XBP1 splicing during ER stress.

The Journal of biological chemistry

Unlu I,Lu Y,Wang X

Fri Dec 14 00:00:00 UTC 2018

The cyclic phosphodiesterase CNP and RNA cyclase RtcA fine-tune noncanonical XBP1 splicing during ER stress.

The Journal of biological chemistry

Unlu I,Lu Y,Wang X

Fri Dec 14 00:00:00 UTC 2018

A synthetic biology approach identifies the mammalian UPR RNA ligase RtcB.

Molecular cell

Lu Y,Liang FX,Wang X

Thu Sep 04 00:00:00 UTC 2014

A synthetic biology approach identifies the mammalian UPR RNA ligase RtcB.

Molecular cell

Lu Y,Liang FX,Wang X

Thu Sep 04 00:00:00 UTC 2014

A synthetic biology approach identifies the mammalian UPR RNA ligase RtcB.

Molecular cell

Lu Y,Liang FX,Wang X

Thu Sep 04 00:00:00 UTC 2014

A synthetic biology approach identifies the mammalian UPR RNA ligase RtcB.

Molecular cell

Lu Y,Liang FX,Wang X

Thu Sep 04 00:00:00 UTC 2014

Bioinformatics

Protein Aliases: 3'-phosphate/5'-hydroxy nucleic acid ligase; ankyrin repeat domain 54; FAAP; Focal adhesion-associated protein; RNA-splicing ligase RtcB homolog; RTCB; tRNA-splicing ligase RtcB homolog

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Gene Aliases: AI255213; AI463255; C22orf28; D10Wsu52e; DJ149A16.6; FAAP; HSPC117; RTCB

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UniProt ID: (Human) Q9Y3I0, (Mouse) Q99LF4

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Entrez Gene ID: (Human) 51493, (Mouse) 28088

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Function(s)

RNA ligase (ATP) activity protein binding ATP binding vinculin binding poly(A) RNA binding metal ion binding nucleotide binding RNA ligase activity ligase activity

Process(es)

in utero embryonic development placenta development tRNA splicing, via endonucleolytic cleavage and ligation RNA processing tRNA processing

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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RtcB Polyclonal Antibody

RtcB Antibody (19809-1-AP) in ICC/IF

Product Details

19809-1-AP

Western Blot (WB)

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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