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Invitrogen
Ruplizumab Recombinant Human Monoclonal Antibody (hu5c8 (Ruplizumab))
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FIGURE: 1 / 1
Ruplizumab Antibody (MA5-47965) in WB
Western Blot analysis of Ruplizumab was performed using Ruplizumab Recombinant Monoclonal Antibody (Product # MA5-47965). Rat spleen (lane 1), rat muscle (lane 2), rat bladder (lane 3), human breast tumor (lane 4) and human thyroid tumor (lane 5) samples were resolved on a 10% SDS PAGE gel and blots probed with Ruplizumab Recombinant Monoclonal Antibody at 1 µg/mL before being detected by a secondary antibody. The expected band size (29 kDa) is seen in the human-derived samples, as well as bands corresponding to dimers and other multimers.
Product Details
MA5-47965
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Human
/ IgG1, kappa
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
hu5c8 (Ruplizumab)
Immunogen
Human CD40L
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS
Contains
0.02% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_3074409
Product Specific Information
Specificity: The antibody binds to CD40L with an IC50 of 0.845 µg/mL.
Target Information
Ruplizumab is a humanized monoclonal antibody used as an immunosuppressive pharmaceutical and is a component of Antova. Ruplizumab is an anti-CD40L monoclonal antibody. The binding of CD40 to its ligand, CD40L is a critical element in T cell activation. In systemic lupus erythematosus, CD40L is over-expressed on T cells, B cells and monocytes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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