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Invitrogen
RyR3 Polyclonal Antibody
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Product Details
PA5-105247
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human RYR3(Accession Q15413), corresponding to amino acid residues A134-L184.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2853853
Product Specific Information
Antibody detects endogenous levels of total RYR3.
Target Information
RYR3 is a ryanodine receptor, which functions to release calcium from intracellular storage for use in many cellular processes. RYR3 is involved in skeletal muscle contraction by releasing calcium from the sarcoplasmic reticulum followed by depolarization of T-tubules. Two transcript variants encoding different isoforms of RYR3 have been found. RYR3 mediates calcium channel release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm in muscle and plays a role in triggering muscle contraction. Further, RYR3 may also regulate Ca(2+) release by other calcium channels, as well as Ca(2+) release from the endoplasmic reticulum in non-muscle cells. RYR3 also contributes to cellular calcium ion homeostasis. Plays a role in cellular calcium signaling. Diseases associated with RYR3 include Central Core Disease and Arrhythmogenic Right Ventricular Dysplasia 2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Brain ryanodine receptor-calcium release channel; Brain-type ryanodine receptor; calcium release channel; Ryanodine receptor 3; RYR-3; Type 3 ryanodine receptor
Gene Aliases: AI851294; C230090H21; HBRR; RYR-3; RYR3
UniProt ID: (Human) Q15413, (Mouse) A2AGL3
Entrez Gene ID: (Human) 6263, (Mouse) 20192
transport
ion transport
calcium ion transport
cellular calcium ion homeostasis
striated muscle contraction
negative regulation of cytosolic calcium ion concentration
transmembrane transport
calcium ion transmembrane transport
ion transmembrane transport
release of sequestered calcium ion into cytosol
protein homotetramerization
cellular response to calcium ion
cellular response to magnesium ion
cellular response to caffeine
cellular response to ATP
regulation of cardiac conduction
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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