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          • Primary Antibodies ›
          • Ryanodine Receptor Antibodies

          Bioss

          Ryanodine Receptor Polyclonal Antibody

          View all (6) Ryanodine Receptor antibodies

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          Cite Ryanodine Receptor Polyclonal Antibody

          • Antibody Testing Data (1)
          Ryanodine Receptor Antibody in Immunohistochemistry (Paraffin) (IHC (P))
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          Ryanodine Receptor Antibody in Immunohistochemistry (Paraffin) (IHC (P))
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          FIGURE: 1 / 1

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          Ryanodine Receptor Antibody (BS-6305R) in IHC (P)

          Formalin-fixed and paraffin embedded rat heart labeled with Anti-Ryanodine Receptor Polyclonal Antibody, Unconjugated (bs-6305R) at 1:200 followed by conjugation to the secondary antibody and DAB staining. {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          Ryanodine Receptor Antibody in Immunohistochemistry (Paraffin) (IHC (P))

          Product Details

          BS-6305R

          Applications
          Tested Dilution
          Publications

          Immunohistochemistry (Paraffin) (IHC (P))

          1:200
          -

          Immunohistochemistry (Frozen) (IHC (F))

          1:100-1:500
          -

          Immunocytochemistry (ICC/IF)

          1:50-1:200
          -

          ELISA (ELISA)

          1:500-1:1,000
          -
          Product Specifications

          Species Reactivity

          Human, Mouse, Rat

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          KLH conjugated synthetic peptide derived from human Ryanodine Receptor.

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          1 mg/mL

          Purification

          Protein A

          Storage buffer

          PBS with 1% BSA, 50% glycerol

          Contains

          0.09% sodium azide

          Storage conditions

          -20°C

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          Target Information

          The ryanodine receptor (RyR) is the channel responsible for the release of calcium from the sarcoplasmic reticulum (SR) in muscle cells and also plays a role in calcium regulation in non-muscle cells. The RyR exists as a homotetramer and is predicted to have a short cytoplasmic C-terminus and 4-10 transmembrane domains; the remainder of the protein, termed the "foot" region is located in the cytoplasm between the T-tubule and the SR. The mammalian RyR is the product of three different genes: RyR-1, which is expressed predominantly in skeletal muscle and areas of the brain, RyR-2, which is expressed predominantly in the heart muscle but also found in the stomach, endothelial cells and diffuse areas of the brain, and RyR-3 which is found in smooth muscle and the brain (striatum, thalamus and hippocampus).

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          References (0)

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          Cite this product

          Bioinformatics

          Protein Aliases: calcium release channel; Cardiac muscle ryanodine receptor; Cardiac muscle ryanodine receptor-calcium release channel; cardiac-type ryanodine receptor; central core disease of muscle; islet-type ryanodine receptor; kidney-type ryanodine receptor; protein phosphatase 1, regulatory subunit 137; Ryanodine receptor 1; ryanodine receptor 1 (skeletal); ryanodine receptor 1, skeletal muscle; ryanodine receptor 1-like, skeletal muscle; Ryanodine receptor 2; ryanodine receptor 2 (cardiac); ryanodine receptor type 2; ryanodine receptor type II; RYR-1; RYR-2; sarcoplasmic reticulum calcium release channel; Skeletal muscle calcium release channel; Skeletal muscle ryanodine receptor; Skeletal muscle-type ryanodine receptor; Type 1 ryanodine receptor; type 1-like ryanodine receptor; Type 2 ryanodine receptor

          View more View less

          Gene Aliases: 9330127I20Rik; AI528790; ARVC2; ARVD2; CCO; MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; RYR-2; RYR1; Ryr1l; RYR2; SKRR; VTSIP

          View more View less

          UniProt ID: (Human) P21817, (Human) Q92736, (Mouse) E9PZQ0, (Rat) B0LPN4, (Mouse) E9Q401

          View more View less

          Entrez Gene ID: (Human) 6261, (Human) 6262, (Mouse) 20190, (Rat) 114207, (Rat) 689560, (Mouse) 20191

          View more View less

          Function(s)
          protease binding ryanodine-sensitive calcium-release channel activity voltage-gated calcium channel activity calcium channel activity calcium ion binding protein binding calmodulin binding calcium-release channel activity enzyme binding protein kinase A catalytic subunit binding protein kinase A regulatory subunit binding identical protein binding protein self-association suramin binding ion channel binding calcium-induced calcium release activity ion channel activity protein kinase binding scaffold protein binding organic cyclic compound binding
          Process(es)
          response to hypoxia outflow tract morphogenesis transport ion transport calcium ion transport cellular calcium ion homeostasis muscle contraction regulation of muscle contraction multicellular organism development release of sequestered calcium ion into cytosol by sarcoplasmic reticulum response to caffeine regulation of ion transmembrane transport skin development ossification involved in bone maturation skeletal muscle fiber development release of sequestered calcium ion into cytosol regulation of cytosolic calcium ion concentration transmembrane transport sarcoplasmic reticulum calcium ion transport calcium ion transmembrane transport cellular response to caffeine regulation of heart rate embryonic heart tube morphogenesis left ventricular cardiac muscle tissue morphogenesis cardiac muscle hypertrophy detection of calcium ion response to nutrient positive regulation of heart rate regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion calcium-mediated signaling BMP signaling pathway response to magnesium ion ion transmembrane transport calcium-mediated signaling using intracellular calcium source response to muscle stretch response to drug positive regulation of sequestering of calcium ion negative regulation of cytosolic calcium ion concentration response to calcium ion response to redox state regulation of cardiac muscle contraction cardiac muscle contraction canonical Wnt signaling pathway cytosolic calcium ion transport calcium ion transport into cytosol manganese ion transmembrane transport establishment of protein localization to endoplasmic reticulum ventricular cardiac muscle cell action potential Purkinje myocyte to ventricular cardiac muscle cell signaling positive regulation of ryanodine-sensitive calcium-release channel activity by adrenergic receptor signaling pathway involved in positive regulation of cardiac muscle contraction type B pancreatic cell apoptotic process positive regulation of the force of heart contraction positive regulation of calcium-transporting ATPase activity regulation of cardiac muscle contraction by calcium ion signaling response to muscle activity cellular response to epinephrine stimulus cell communication by electrical coupling involved in cardiac conduction regulation of AV node cell action potential regulation of SA node cell action potential regulation of atrial cardiac muscle cell action potential regulation of ventricular cardiac muscle cell action potential regulation of cardiac conduction
          It has to be done as per old AB suggested Products section.
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