Invitrogen

Ryanodine Receptor Polyclonal Antibody

View all (6) Ryanodine Receptor antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-109278

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:50-1:100
-

Flow Cytometry (Flow)

1:50-1:100
-

Dot blot (DB)

1:500
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide within Human RYR2 aa 1,471-1,520
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol, 0.2% BSA

Contains

0.05% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles, store in dark

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2854689

Product Specific Information

Positive Control: 293T, LOVO, SH-SY-5Y, human fetal skeletal muscle tissue, mouse brain tissue, mouse cerebellum tissue, rat skeletal muscle tissue.

Target Information

The ryanodine receptor (RyR) is the channel responsible for the release of calcium from the sarcoplasmic reticulum (SR) in muscle cells and also plays a role in calcium regulation in non-muscle cells. The RyR exists as a homotetramer and is predicted to have a short cytoplasmic C-terminus and 4-10 transmembrane domains; the remainder of the protein, termed the "foot" region is located in the cytoplasm between the T-tubule and the SR. The mammalian RyR is the product of three different genes: RyR-1, which is expressed predominantly in skeletal muscle and areas of the brain, RyR-2, which is expressed predominantly in the heart muscle but also found in the stomach, endothelial cells and diffuse areas of the brain, and RyR-3 which is found in smooth muscle and the brain (striatum, thalamus and hippocampus).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Cardiac muscle ryanodine receptor; Cardiac muscle ryanodine receptor-calcium release channel; cardiac-type ryanodine receptor; central core disease of muscle; islet-type ryanodine receptor; kidney-type ryanodine receptor; protein phosphatase 1, regulatory subunit 137; Ryanodine receptor 1; ryanodine receptor 1 (skeletal); Ryanodine receptor 2; ryanodine receptor 2 (cardiac); RYR-1; RYR-2; sarcoplasmic reticulum calcium release channel; Skeletal muscle calcium release channel; Skeletal muscle ryanodine receptor; Skeletal muscle-type ryanodine receptor; Type 1 ryanodine receptor; type 1-like ryanodine receptor; Type 2 ryanodine receptor

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Gene Aliases: ARVC2; ARVD2; CCO; MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; RYR-2; RYR1; RYR2; SKRR; VTSIP

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UniProt ID: (Human) P21817, (Human) Q92736

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Entrez Gene ID: (Human) 6261, (Human) 6262

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Function(s)
protease binding ryanodine-sensitive calcium-release channel activity voltage-gated calcium channel activity calcium channel activity calcium ion binding protein binding calmodulin binding calcium-release channel activity enzyme binding protein kinase A catalytic subunit binding protein kinase A regulatory subunit binding identical protein binding protein self-association suramin binding ion channel binding calcium-induced calcium release activity
Process(es)
response to hypoxia regulation of heart rate embryonic heart tube morphogenesis left ventricular cardiac muscle tissue morphogenesis cardiac muscle hypertrophy detection of calcium ion calcium ion transport cellular calcium ion homeostasis positive regulation of heart rate regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion regulation of cardiac muscle contraction by calcium ion signaling release of sequestered calcium ion into cytosol by sarcoplasmic reticulum response to muscle activity calcium-mediated signaling BMP signaling pathway response to caffeine ion transmembrane transport calcium-mediated signaling using intracellular calcium source response to muscle stretch release of sequestered calcium ion into cytosol positive regulation of sequestering of calcium ion regulation of cytosolic calcium ion concentration response to redox state regulation of cardiac muscle contraction cardiac muscle contraction canonical Wnt signaling pathway calcium ion transport into cytosol sarcoplasmic reticulum calcium ion transport cellular response to caffeine cellular response to epinephrine stimulus establishment of protein localization to endoplasmic reticulum ventricular cardiac muscle cell action potential Purkinje myocyte to ventricular cardiac muscle cell signaling cell communication by electrical coupling involved in cardiac conduction type B pancreatic cell apoptotic process positive regulation of the force of heart contraction regulation of AV node cell action potential regulation of SA node cell action potential regulation of atrial cardiac muscle cell action potential regulation of ventricular cardiac muscle cell action potential positive regulation of calcium-transporting ATPase activity regulation of cardiac conduction outflow tract morphogenesis muscle contraction skin development ossification involved in bone maturation skeletal muscle fiber development
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