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Invitrogen
S100A10 Recombinant Rabbit Monoclonal Antibody (6A4Z3)
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FIGURE: 1 / 6
S100A10 Antibody (MA5-51501) in IHC (P)
Immunohistochemistry analysis of S100A10 in paraffin-embedded human liver cancer. Samples were incubated with S100A10 Recombinant monoclonal antibody (Product # MA5-51501) using a dilution of 1:200 (40x lens). High pressure antigen retrieval was performed with 0.01 M citrate buffer (pH 6.0) prior to IHC staining.
Product Details
MA5-51501
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
6A4Z3
Immunogen
Recombinant protein of human S100A10.
Conjugate
Form
Liquid
Concentration
0.08 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 0.05% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_3094171
Target Information
The S-100 family of calcium-activated proteins interact with a range of target proteins to modulate biological signaling pathways. Numerous cancer cell lines overexpress the plasminogen receptor S-100A10 on the extracellular cell surface, where it forms a heterotetrameric complex with Annexin II, though this association is not required for plasma membrane localization or binding and activation of plasminogen. Additionally, S-100A10 acts as a cellular chaperone for hepatitis B (Hep B) virus polymerase. Hep B virus polymerase normally localizes to the cytoplasm only, though in the presence of S-100A10 a portion relocates to the nucleus, implying a role for S-100A10 and intracellular calcium in the process of viral replication.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Annexin II; annexin II ligand; annexin II ligand, calpactin I, light polypeptide; annexin II tetramer (AIIt) p11 subunit; calcium binding protein A11 (calgizzarin); Calpactin I light chain; Calpactin-1 light chain; Cellular ligand of annexin II; MGC111133; MGC133268; Nerve growth factor-induced protein 42C; OTTHUMP00000015270; P PRSS26; p10 protein; p11; p11 subunit; Protein S100 A10; Protein S100-A10; S-100 related protein, clone 42C; S100 calcium binding protein A10 (annexin II ligand, calpactin I, light polypeptide (p11)); S100 calcium binding protein A10 (calgizzarin); S100 calcium-binding protein A10; S100 calcium-binding protein A10 (annexin II ligand, calpactin I, light polypeptide (p11))
Gene Aliases: 42C; AA409961; AL024248; ANX2L; ANX2LG; Ca[1]; CAL12; CAL1L; CLP11; GP11; p10; P11; S100A10
UniProt ID: (Human) P60903, (Rat) P05943, (Mouse) P08207
Entrez Gene ID: (Human) 6281, (Rat) 81778, (Mouse) 20194
regulation of cell growth
membrane raft assembly
membrane budding
response to antidepressant
regulation of cell differentiation
positive regulation of binding
protein heterotetramerization
positive regulation of stress fiber assembly
positive regulation of focal adhesion assembly
establishment of protein localization to plasma membrane
positive regulation of substrate adhesion-dependent cell spreading
positive regulation of GTPase activity
cellular response to acid chemical
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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