Proteintech

S100A6 Polyclonal Antibody

S100A6 Antibody in Immunocytochemistry (ICC/IF)

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S100A6 Antibody (10245-1-AP) in ICC/IF

Immunofluorescent analysis of MCF-7 cells, using S100A6 antibody 10245-1-AP at 1:50 dilution and Rhodamine-labeled goat anti-rabbit IGG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).

S100A6 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

S100A6 Antibody in Flow Cytometry (Flow)

S100A6 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

10245-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 12 publications 12 publications

Immunohistochemistry (IHC)

View 5 publications 5 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

1:20-1:200

View 4 publications 4 publications

Flow Cytometry (Flow)

0.2 µg/1x10^6 cells

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

S100A6 Fusion Protein Ag0385 (1-90 aa encoded by BC001431)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.28 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

The antibody is specific for S100A6.

Immunogen sequence: MACPLDQAI GLLVAIFHKY SGREGDKHTL SKKELKELIQ KELTIGSKLQ DAEIARLMED LDRNKDQEVN FQEYVTFLGA LALIYNEALK G (1-90 aa encoded by BC001431)

Target Information

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-dependent insulin release, stimulation of prolactin secretion, and exocytosis. Chromosomal rearrangements and altered expression of this gene have been implicated in melanoma.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

S100A6 promotes the development of thyroid cancer and inhibits apoptosis of thyroid cancer cells through the PI3K/AKT/mTOR pathway.

Pathology, research and practice

Chen B,Zheng D,Liu C,Bhandari A,Hirachan S,Shen C,Mainali S,Li H,Jiang W,Xu J,Zhang X,Tang K,Zhang W

Wed Feb 01 00:00:00 UTC 2023

WT1⁺ glomerular parietal epithelial progenitors promote renal proximal tubule regeneration after severe acute kidney injury.

Theranostics

Hong X,Nie H,Deng J,Liang S,Chen L,Li J,Gong S,Wang G,Zuo W,Hou F,Zhang F

Mon Mar 20 00:00:00 UTC 2023

ANXA11 biomolecular condensates facilitate protein-lipid phase coupling on lysosomal membranes.

bioRxiv : the preprint server for biology

Nixon-Abell J,Ruggeri FS,Qamar S,Herling TW,Czekalska MA,Shen Y,Wang G,King C,Fernandopulle MS,Sneideris T,Watson JL,Pillai VVS,Meadows W,Henderson JW,Chambers JE,Wagstaff JL,Williams SH,Coyle H,Lu Y,Zhang S,Marciniak SJ,Freund SMV,Derivery E,Ward ME,Vendruscolo M,Knowles TPJ,St George-Hyslop P

Fri Mar 24 00:00:00 UTC 2023

Cellular architecture of human brain metastases.

Cell

Gonzalez H,Mei W,Robles I,Hagerling C,Allen BM,Hauge Okholm TL,Nanjaraj A,Verbeek T,Kalavacherla S,van Gogh M,Georgiou S,Daras M,Phillips JJ,Spitzer MH,Roose JP,Werb Z

Thu Feb 17 00:00:00 UTC 2022

Candidate therapeutic agents in a newly established triple wild-type mucosal melanoma cell line.

Cancer communications (London, England)

Shi C,Gu Z,Xu S,Ju H,Wu Y,Han Y,Li J,Li C,Wu J,Wang L,Li J,Zhou G,Ye W,Ren G,Zhang Z,Zhou R

Fri Jul 01 00:00:00 UTC 2022

Genetic screening of ANXA11 revealed novel mutations linked to amyotrophic lateral sclerosis.

Neurobiology of aging

Teyssou E,Muratet F,Amador MD,Ferrien M,Lautrette G,Machat S,Boillée S,Larmonier T,Saker S,Leguern E,Cazeneuve C,Marie Y,Guegan J,Gyorgy B,Cintas P,Meininger V,Le Forestier N,Salachas F,Couratier P,Camu W,Seilhean D,Millecamps S

Mon Mar 01 00:00:00 UTC 2021

Genetic screening of ANXA11 revealed novel mutations linked to amyotrophic lateral sclerosis.

Neurobiology of aging

Mon Mar 01 00:00:00 UTC 2021

c-Myc Upregulated by High Glucose Inhibits HaCaT Differentiation by S100A6 Transcriptional Activation.

Frontiers in endocrinology

Zhang J,Yang P,Liu D,Gao M,Wang J,Wang X,Liu Y,Zhang X

Wed Dec 22 00:00:00 UTC 2021

Single-cell reconstruction of the adult human heart during heart failure and recovery reveals the cellular landscape underlying cardiac function.

Nature cell biology

Wang L,Yu P,Zhou B,Song J,Li Z,Zhang M,Guo G,Wang Y,Chen X,Han L,Hu S

Wed Jan 01 00:00:00 UTC 2020

ZEB1 and IL-6/11-STAT3 signalling cooperate to define invasive potential of pancreatic cancer cells via differential regulation of the expression of S100 proteins.

British journal of cancer

Al-Ismaeel Q,Neal CP,Al-Mahmoodi H,Almutairi Z,Al-Shamarti I,Straatman K,Jaunbocus N,Irvine A,Issa E,Moreman C,Dennison AR,Emre Sayan A,McDearmid J,Greaves P,Tulchinsky E,Kriajevska M

Mon Jul 01 00:00:00 UTC 2019

Mutations in the vesicular trafficking protein annexin A11 are associated with amyotrophic lateral sclerosis.

Science translational medicine

Smith BN,Topp SD,Fallini C,Shibata H,Chen HJ,Troakes C,King A,Ticozzi N,Kenna KP,Soragia-Gkazi A,Miller JW,Sato A,Dias DM,Jeon M,Vance C,Wong CH,de Majo M,Kattuah W,Mitchell JC,Scotter EL,Parkin NW,Sapp PC,Nolan M,Nestor PJ,Simpson M,Weale M,Lek M,Baas F,Vianney de Jong JM,Ten Asbroek ALMA,Redondo AG,Esteban-Pérez J,Tiloca C,Verde F,Duga S,Leigh N,Pall H,Morrison KE,Al-Chalabi A,Shaw PJ,Kirby J,Turner MR,Talbot K,Hardiman O,Glass JD,De Belleroche J,Maki M,Moss SE,Miller C,Gellera C,Ratti A,Al-Sarraj S,Brown RH,Silani V,Landers JE,Shaw CE

Wed May 03 00:00:00 UTC 2017

Mutations in the vesicular trafficking protein annexin A11 are associated with amyotrophic lateral sclerosis.

Science translational medicine

Wed May 03 00:00:00 UTC 2017

Mutations in the vesicular trafficking protein annexin A11 are associated with amyotrophic lateral sclerosis.

Science translational medicine

Wed May 03 00:00:00 UTC 2017

S100A6 promotes cell proliferation in human nasopharyngeal carcinoma via the p38/MAPK signaling pathway.

Molecular carcinogenesis

Li A,Shi D,Xu B,Wang J,Tang YL,Xiao W,Shen G,Deng W,Zhao C

Wed Mar 01 00:00:00 UTC 2017

S100A6 promotes cell proliferation in human nasopharyngeal carcinoma via the p38/MAPK signaling pathway.

Molecular carcinogenesis

Li A,Shi D,Xu B,Wang J,Tang YL,Xiao W,Shen G,Deng W,Zhao C

Wed Mar 01 00:00:00 UTC 2017

S100A6 promotes cell proliferation in human nasopharyngeal carcinoma via the p38/MAPK signaling pathway.

Molecular carcinogenesis

Li A,Shi D,Xu B,Wang J,Tang YL,Xiao W,Shen G,Deng W,Zhao C

Wed Mar 01 00:00:00 UTC 2017

S100A6 promotes cell proliferation in human nasopharyngeal carcinoma via the p38/MAPK signaling pathway.

Molecular carcinogenesis

Li A,Shi D,Xu B,Wang J,Tang YL,Xiao W,Shen G,Deng W,Zhao C

Wed Mar 01 00:00:00 UTC 2017

S100A6 as a potential serum prognostic biomarker and therapeutic target in gastric cancer.

Digestive diseases and sciences

Zhang J,Zhang K,Jiang X,Zhang J

Mon Sep 01 00:00:00 UTC 2014

S100A6 as a potential serum prognostic biomarker and therapeutic target in gastric cancer.

Digestive diseases and sciences

Zhang J,Zhang K,Jiang X,Zhang J

Mon Sep 01 00:00:00 UTC 2014

Protein profiling the differences between diabetic and normal mouse cumulus cells.

Molecular reproduction and development

Jiang GJ,Ma JY,Zhang GL,Mo FF,Zhang DW,Gao SH,Li XL

Mon Dec 01 00:00:00 UTC 2014

Protein profiling the differences between diabetic and normal mouse cumulus cells.

Molecular reproduction and development

Jiang GJ,Ma JY,Zhang GL,Mo FF,Zhang DW,Gao SH,Li XL

Mon Dec 01 00:00:00 UTC 2014

Ca(2+) /S100 proteins regulate HCV virus NS5A-FKBP8/FKBP38 interaction and HCV virus RNA replication.

Liver international : official journal of the International Association for the Study of the Liver

Tani J,Shimamoto S,Mori K,Kato N,Moriishi K,Matsuura Y,Tokumitsu H,Tsuchiya M,Fujimoto T,Kato K,Miyoshi H,Masaki T,Kobayashi R

Thu Aug 01 00:00:00 UTC 2013

Ca(2+) /S100 proteins regulate HCV virus NS5A-FKBP8/FKBP38 interaction and HCV virus RNA replication.

Liver international : official journal of the International Association for the Study of the Liver

Tani J,Shimamoto S,Mori K,Kato N,Moriishi K,Matsuura Y,Tokumitsu H,Tsuchiya M,Fujimoto T,Kato K,Miyoshi H,Masaki T,Kobayashi R

Thu Aug 01 00:00:00 UTC 2013

S100 proteins regulate the interaction of Hsp90 with Cyclophilin 40 and FKBP52 through their tetratricopeptide repeats.

FEBS letters

Shimamoto S,Kubota Y,Tokumitsu H,Kobayashi R

Fri Mar 19 00:00:00 UTC 2010

S100 proteins regulate the interaction of Hsp90 with Cyclophilin 40 and FKBP52 through their tetratricopeptide repeats.

FEBS letters

Shimamoto S,Kubota Y,Tokumitsu H,Kobayashi R

Fri Mar 19 00:00:00 UTC 2010

Proteomic analysis of lung tissue of rats exposed to cigarette smoke and radon.