Proteintech

S100A8 Polyclonal Antibody

S100A8 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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S100A8 Antibody (15792-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded human stomach cancer tissue slide using 15792-1-AP (S100A8 antibody) at dilution of 1:400 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

S100A8 Antibody in Flow Cytometry (Flow)

Product Image Gallery

Product Details

15792-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:600

View 18 publications 18 publications

Immunohistochemistry (IHC)

View 4 publications 4 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:400

Immunocytochemistry (ICC/IF)

View 5 publications 5 publications

Flow Cytometry (Flow)

0.4 µg

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

S100A8 Fusion Protein Ag8500

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

267 µg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

Product Specific Information

Aliquoting is unnecessary for -20°C storage.

Target Information

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase and as a cytokine. Altered expression of this protein is associated with the disease cystic fibrosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Fra-1 induces apoptosis and neuroinflammation by targeting S100A8 to modulate TLR4 pathways in spinal cord ischemia/reperfusion injury.

Brain pathology (Zurich, Switzerland)

Chen Y,Dong Y,Zhang ZL,Han J,Chen FS,Tong XY,Ma H

Sun Jan 01 00:00:00 UTC 2023

Senescent immune cells accumulation promotes brown adipose tissue dysfunction during aging.

Nature communications

Feng X,Wang L,Zhou R,Zhou R,Chen L,Peng H,Huang Y,Guo Q,Luo X,Zhou H

Fri Jun 02 00:00:00 UTC 2023

Senescent immune cells accumulation promotes brown adipose tissue dysfunction during aging.

Nature communications

Feng X,Wang L,Zhou R,Zhou R,Chen L,Peng H,Huang Y,Guo Q,Luo X,Zhou H

Fri Jun 02 00:00:00 UTC 2023

Senescent immune cells accumulation promotes brown adipose tissue dysfunction during aging.

Nature communications

Feng X,Wang L,Zhou R,Zhou R,Chen L,Peng H,Huang Y,Guo Q,Luo X,Zhou H

Fri Jun 02 00:00:00 UTC 2023

S100A8 regulates autophagy-dependent ferroptosis in microglia after experimental subarachnoid hemorrhage.

Experimental neurology

Tao Q,Qiu X,Li C,Zhou J,Gu L,Zhang L,Pang J,Zhang L,Yin S,Jiang Y,Peng J

Tue Nov 01 00:00:00 UTC 2022

S100A8 regulates autophagy-dependent ferroptosis in microglia after experimental subarachnoid hemorrhage.

Experimental neurology

Tao Q,Qiu X,Li C,Zhou J,Gu L,Zhang L,Pang J,Zhang L,Yin S,Jiang Y,Peng J

Tue Nov 01 00:00:00 UTC 2022

Effects of ambient PM_2.5 on development of psoriasiform inflammation through KRT17-dependent activation of AKT/mTOR/HIF-1α pathway.

Ecotoxicology and environmental safety

Wang X,Niu L,Kang A,Pang Y,Zhang Y,Wang W,Zhang Y,Huang X,Liu Q,Geng Z,He L,Niu Y,Zhang R

Thu Sep 15 00:00:00 UTC 2022

Hexokinase 1 cellular localization regulates the metabolic fate of glucose.

Molecular cell

De Jesus A,Keyhani-Nejad F,Pusec CM,Goodman L,Geier JA,Stoolman JS,Stanczyk PJ,Nguyen T,Xu K,Suresh KV,Chen Y,Rodriguez AE,Shapiro JS,Chang HC,Chen C,Shah KP,Ben-Sahra I,Layden BT,Chandel NS,Weinberg SE,Ardehali H

Thu Apr 07 00:00:00 UTC 2022

The heterogeneous immune landscape between lung adenocarcinoma and squamous carcinoma revealed by single-cell RNA sequencing.

Signal transduction and targeted therapy

Wang C,Yu Q,Song T,Wang Z,Song L,Yang Y,Shao J,Li J,Ni Y,Chao N,Zhang L,Li W

Fri Aug 26 00:00:00 UTC 2022

S100A9-CXCL12 activation in BRCA1-mutant breast cancer promotes an immunosuppressive microenvironment associated with resistance to immunotherapy.

Nature communications

Li J,Shu X,Xu J,Su SM,Chan UI,Mo L,Liu J,Zhang X,Adhav R,Chen Q,Wang Y,An T,Zhang X,Lyu X,Li X,Lei JH,Miao K,Sun H,Xing F,Zhang A,Deng C,Xu X

Fri Mar 18 00:00:00 UTC 2022

S100A9-CXCL12 activation in BRCA1-mutant breast cancer promotes an immunosuppressive microenvironment associated with resistance to immunotherapy.

Nature communications

Li J,Shu X,Xu J,Su SM,Chan UI,Mo L,Liu J,Zhang X,Adhav R,Chen Q,Wang Y,An T,Zhang X,Lyu X,Li X,Lei JH,Miao K,Sun H,Xing F,Zhang A,Deng C,Xu X

Fri Mar 18 00:00:00 UTC 2022

Comprehensive Profiling of Early Neoplastic Gastric Microenvironment Modifications and Biodynamics in Impaired BMP-Signaling FoxL1⁺-Telocytes.

Biomedicines

Alfonso AB,Pomerleau V,Nicolás VR,Raisch J,Jurkovic CM,Boisvert FM,Perreault N

Thu Dec 22 00:00:00 UTC 2022

Inflammatory markers S100A8/A9 and metabolic alteration for evaluating signs of early phase toxicity of anticancer agent treatment.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

Morikawa-Ichinose T,Fujimura Y,Kumazoe M,Onda H,Miura D,Tachibana H

Tue Nov 01 00:00:00 UTC 2022

Triptolide analog LLDT-8 ameliorates psoriasis-like dermatitis in BALB/c mice via suppressing the IL-36α signaling pathway.

Pharmacological research

Qi Q,Li Q,Zhu H,Lu H,Yang X,Wu Y,Feng C,Fan C,Li H,Wu B,Gao Y,Zhang Z,Zhou H,Zuo J,Tang W

Thu Jul 01 00:00:00 UTC 2021

Bulk and single-cell transcriptome profiling reveal the metabolic heterogeneity in human breast cancers.

Molecular therapy : the journal of the American Society of Gene Therapy

Yu TJ,Ma D,Liu YY,Xiao Y,Gong Y,Jiang YZ,Shao ZM,Hu X,Di GH

Wed Jul 07 00:00:00 UTC 2021

Keratin 1 attenuates hypoxic pulmonary artery hypertension by suppressing pulmonary artery media smooth muscle expansion.

Acta physiologica (Oxford, England)

Zhang L,Zeng XX,Li YM,Chen SK,Tang LY,Wang N,Yang X,Lin MJ

Mon Feb 01 00:00:00 UTC 2021

Curcumin increases the sensitivity of K562/DOX cells to doxorubicin by targeting S100 calcium-binding protein A8 and P-glycoprotein.

Oncology letters

Yang L,Li D,Tang P,Zuo Y

Wed Jan 01 00:00:00 UTC 2020

Inhibition of keratinocyte necroptosis mediated by RIPK1/RIPK3/MLKL provides a protective effect against psoriatic inflammation.

Cell death & disease

Duan X,Liu X,Liu N,Huang Y,Jin Z,Zhang S,Ming Z,Chen H

Wed Feb 19 00:00:00 UTC 2020

BRG1 Stimulates Endothelial Derived Alarmin MRP8 to Promote Macrophage Infiltration in an Animal Model of Cardiac Hypertrophy.

Frontiers in cell and developmental biology

Li Z,Zhang Y,Zhang Y,Yu L,Xiao B,Li T,Kong X,Xu Y

Fri Feb 12 00:00:00 UTC 2021

BRG1 Stimulates Endothelial Derived Alarmin MRP8 to Promote Macrophage Infiltration in an Animal Model of Cardiac Hypertrophy.

Frontiers in cell and developmental biology

Li Z,Zhang Y,Zhang Y,Yu L,Xiao B,Li T,Kong X,Xu Y

Fri Feb 12 00:00:00 UTC 2021

Global Proteome and Phosphoproteome Characterization of Sepsis-induced Kidney Injury.

Molecular & cellular proteomics : MCP

Lin YH,Platt MP,Fu H,Gui Y,Wang Y,Gonzalez-Juarbe N,Zhou D,Yu Y

Tue Dec 01 00:00:00 UTC 2020

Human Isogenic Cell Line Models for Neutrophils and Myeloid-Derived Suppressor Cells.

International journal of molecular sciences

Zhang Y,Wilt E,Lu X

Sun Oct 18 00:00:00 UTC 2020

KRAS-IRF2 Axis Drives Immune Suppression and Immune Therapy Resistance in Colorectal Cancer.

Cancer cell

Liao W,Overman MJ,Boutin AT,Shang X,Zhao D,Dey P,Li J,Wang G,Lan Z,Li J,Tang M,Jiang S,Ma X,Chen P,Katkhuda R,Korphaisarn K,Chakravarti D,Chang A,Spring DJ,Chang Q,Zhang J,Maru DM,Maeda DY,Zebala JA,Kopetz S,Wang YA,DePinho RA

Mon Apr 15 00:00:00 UTC 2019

Pancreatic cancer-derived exosomes promote tumor metastasis and liver pre-metastatic niche formation.

Oncotarget

Yu Z,Zhao S,Ren L,Wang L,Chen Z,Hoffman RM,Zhou J

Fri Sep 08 00:00:00 UTC 2017

Pancreatic cancer-derived exosomes promote tumor metastasis and liver pre-metastatic niche formation.

Oncotarget

Yu Z,Zhao S,Ren L,Wang L,Chen Z,Hoffman RM,Zhou J

Fri Sep 08 00:00:00 UTC 2017

HRD1 sensitizes breast cancer cells to Tamoxifen by promoting S100A8 degradation.

Oncotarget

Wang Y,Guo A,Liang X,Li M,Shi M,Li Y,Jenkins G,Lin X,Wei X,Jia Z,Feng X,Su D,Guo W

Tue Apr 04 00:00:00 UTC 2017

HRD1 sensitizes breast cancer cells to Tamoxifen by promoting S100A8 degradation.

Oncotarget

Wang Y,Guo A,Liang X,Li M,Shi M,Li Y,Jenkins G,Lin X,Wei X,Jia Z,Feng X,Su D,Guo W

Tue Apr 04 00:00:00 UTC 2017

Protein profiling the differences between diabetic and normal mouse cumulus cells.

Molecular reproduction and development

Jiang GJ,Ma JY,Zhang GL,Mo FF,Zhang DW,Gao SH,Li XL

Mon Dec 01 00:00:00 UTC 2014

Bioinformatics

Protein Aliases: calgranulin A; Calgranulin-A; Calprotectin L1L subunit; CFAG; Chemotactic cytokine CP-10; chemotactic S100 protein; Cystic fibrosis antigen; Leukocyte L1 complex light chain; Migration inhibitory factor-related protein 8; MRP-8; Pro-inflammatory S100 cytokine; Protein S100-A8; S100 A8; S100 calcium-binding protein A8; S100 calcium-binding protein A8 (calgranulin A); Urinary stone protein band A

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Gene Aliases: 60B8AG; AI323541; B8Ag; CAGA; CFAG; CGLA; CP-10; L1Ag; MA387; MIF; MRP8; NIF; P8; S100A8

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UniProt ID: (Human) P05109, (Mouse) P27005

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Entrez Gene ID: (Human) 6279, (Mouse) 20201

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Function(s)

calcium ion binding protein binding microtubule binding zinc ion binding Toll-like receptor 4 binding arachidonic acid binding RAGE receptor binding antioxidant activity metal ion binding

Process(es)

immune system process leukocyte migration involved in inflammatory response positive regulation of peptide secretion autophagy apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic process chemotaxis inflammatory response peptidyl-cysteine S-nitrosylation neutrophil chemotaxis innate immune response regulation of inflammatory response positive regulation of inflammatory response neutrophil aggregation positive regulation of intrinsic apoptotic signaling pathway cytokine production acute inflammatory response chronic inflammatory response response to zinc ion astrocyte development positive regulation of cell growth sequestering of zinc ion response to lipopolysaccharide chemokine production wound healing defense response to bacterium response to ethanol defense response to fungus positive regulation of NF-kappaB transcription factor activity regulation of cytoskeleton organization

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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S100A8 Polyclonal Antibody

S100A8 Antibody (15792-1-AP) in IHC (P)

Product Details

15792-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Species Reactivity

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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