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S100A8 Antibody (PA5-95847) in IHC (P)
Immunohistochemistry analysis of S100A8 in paraffin-embedded extranodal NK-T-cell lymphoma. Samples were incubated with S100A8 Polyclonal antibody (Product # PA5-95847) using a dilution of 1:50 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.
Product Details
PA5-95847
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-93 of human S100A8 (NP_0029552)
Conjugate
Form
Liquid
Concentration
4.45 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2807649
Product Specific Information
Immunogen sequence: MLTELEKALN SIIDVYHKYS LIKGNFHAVY RDDLKKLLET ECPQYIRKKG ADVWFKELDI NTDGAVNFQE FLILVIKMGV AAHKKSHEES HKE; Positive Samples: THP-1; Cellular Location: Cell membrane, Cytoplasm, Peripheral membrane protein, cytoskeleton
Target Information
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase and as a cytokine. Altered expression of this protein is associated with the disease cystic fibrosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: calgranulin A; Calgranulin-A; Calprotectin L1L subunit; CFAG; Chemotactic cytokine CP-10; chemotactic S100 protein; Cystic fibrosis antigen; Leukocyte L1 complex light chain; Migration inhibitory factor-related protein 8; MRP-8; p8; Pro-inflammatory S100 cytokine; Protein S100-A8; S100 A8; S100 calcium binding protein A8 (calgranulin A); S100 calcium-binding protein A8; S100 calcium-binding protein A8 (calgranulin A); Urinary stone protein band A
Gene Aliases: 60B8AG; AI323541; B8Ag; CAGA; CFAG; CGLA; CP-10; L1Ag; MA387; MIF; MRP8; NIF; P8; S100A8
UniProt ID: (Human) P05109, (Rat) P50115, (Mouse) P27005
Entrez Gene ID: (Human) 6279, (Rat) 116547, (Mouse) 20201
leukocyte migration involved in inflammatory response
acute inflammatory response
chronic inflammatory response
positive regulation of peptide secretion
autophagy
activation of cysteine-type endopeptidase activity involved in apoptotic process
inflammatory response
response to zinc ion
neutrophil chemotaxis
response to lipopolysaccharide
wound healing
innate immune response
response to ethanol
positive regulation of inflammatory response
neutrophil aggregation
positive regulation of intrinsic apoptotic signaling pathway
immune system process
apoptotic process
chemotaxis
peptidyl-cysteine S-nitrosylation
regulation of inflammatory response
cytokine production
astrocyte development
positive regulation of cell growth
sequestering of zinc ion
chemokine production
defense response to bacterium
defense response to fungus
positive regulation of NF-kappaB transcription factor activity
regulation of cytoskeleton organization
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