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Invitrogen
S6 Monoclonal Antibody (C.896.4)
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S6 Antibody (MA5-15123) in ICC/IF
Immunofluorescent analysis of S6 Ribosomal Protein in HeLa cells using a S6 Ribosomal Protein monoclonal antibody (Product # MA5-15123) (red). Actin filaments have been labeled with FITC-conjugated phalloidin. DNA is labeled using a fluorescent blue dye.
Product Details
MA5-15123
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Fruit fly,
Human,
Mouse,
Non-human primate,
Rat
Published species
Human,
Mouse
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
C.896.4
Immunogen
Recombinant fusion protein corresponding to full-length human S6 ribosomal protein
Conjugate
Form
Liquid
Concentration
4 µg/mL
Purification
Affinity chromatography
Storage buffer
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
Contains
<0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_10999800
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 40S subunit. The protein belongs to the S6E family of ribosomal proteins. It is the major substrate of protein kinases in the ribosome, with subsets of five C-terminal serine residues phosphorylated by different protein kinases. Phosphorylation is induced by a wide range of stimuli, including growth factors, tumor-promoting agents, and mitogens. Dephosphorylation occurs at growth arrest. The protein may contribute to the control of cell growth and proliferation through the selective translation of particular classes of mRNA. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 40S ribosomal protein S6; CG10944-PA; CG10944-PB; hemocytes enlarged; lethal(1)aberrant immune response[8]; lethal-(1)-haemocytes enlarged; lethal-aberrant-immune-response-8; minute; minute (1) 7BC; OTTHUMP00000021121; OTTHUMP00000021122; Phosphoprotein NP33; ribosomal protein S6; RP11-513M16.6; RpS6-PA; RpS6-PB; RS6; S6 ribosomal protein; Small ribosomal subunit protein eS6
Gene Aliases: (Rp)S6; air8; air[8]; anon-WO02059370.61; CG10944; Dmel\CG10944; Dmel_CG10944; DS6; hen; l(1)air8; l(1)air[8]; l(1)hen; M(1)7BC; M(1)7C; OK/SW-cl.2; pp30; Rp S6; RPS6; S6; S6R
UniProt ID: (Human) P62753, (Fruit fly) P29327, (Mouse) P62754, (Rat) P62755
Entrez Gene ID: (Human) 6194, (Fruit fly) 31700, (Mouse) 20104, (Rat) 29304
mitotic spindle elongation
rRNA processing
translation
immune response
mitotic spindle organization
ribosomal small subunit biogenesis
centrosome duplication
G1/S transition of mitotic cell cycle
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
placenta development
T cell proliferation involved in immune response
translational initiation
SRP-dependent cotranslational protein targeting to membrane
activation-induced cell death of T cells
mitotic nuclear division
mitotic cell cycle checkpoint
gastrulation
viral transcription
oogenesis stage
TOR signaling
T cell differentiation in thymus
glucose homeostasis
positive regulation of apoptotic process
negative regulation of apoptotic process
erythrocyte development
ribosomal small subunit assembly
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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