Proteintech

SACM1L Polyclonal Antibody

SACM1L Antibody in Immunocytochemistry (ICC/IF)

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SACM1L Antibody (13033-1-AP) in ICC/IF

Immunofluorescent analysis of ( -20°C Ethanol) fixed A549 cells using 13033-1-AP (SACM1L antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

SACM1L Antibody in Immunohistochemistry (Paraffin) (IHC (P))

SACM1L Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

13033-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 14 publications 14 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:50-1:500

View 5 publications 5 publications

Immunoprecipitation (IP)

0.5-4.0 µg

View 1 publication 1 publication

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

SACM1L Fusion Protein Ag3682 (154-500 aa encoded by BC016559)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.41 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: QEMSLLERA DQRFVWNGHL LRELSAQPEV HRFALPVLHG FITMHSCSIN GKYFDWILIS RRSCFRAGVR YYVRGIDSEG HAANFVETEQ IVHYNGSKAS FVQTRGSIPV FWSQRPNLKY KPLPQISKVA NHMDGFQRHF DSQVIIYGKQ VIINLINQKG SEKPLEQTFA TMVSSLGSGM MRYIAFDFHK ECKNMRWDRL SILLDQVAEM QDELSYFLVD SAGQVVANQE GVFRSNCMDC LDRTNVIQSL LARRSLQAQL QRLGVLHVGQ KLEEQDEFEK IFKNAWADNA NACAKQYAGT GALKTDFTRT GKRTHLGLIM DGWNSMIRYY KNNFSDGFRQ DSIDLFLG (154-500 aa encoded by BC016559)

Target Information

Phosphoinositide phosphatase that hydrolyzes PtdIns(3)P and PtdIns(4)P. Has low activity towards PtdIns(3,5)P2.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Elucidation of the Cellular Interactome of African Swine Fever Virus Fusion Proteins and Identification of Potential Therapeutic Targets.

Viruses

García-Dorival I,Cuesta-Geijo MÁ,Galindo I,Del Puerto A,Barrado-Gil L,Urquiza J,Alonso C

Sat Apr 29 00:00:00 UTC 2023

Profiling of purified autophagic vesicle degradome in the maturing and aging brain.

Neuron

Kallergi E,Siva Sankar D,Matera A,Kolaxi A,Paolicelli RC,Dengjel J,Nikoletopoulou V

Wed Aug 02 00:00:00 UTC 2023

Lipid phosphatase SAC1 suppresses hepatitis B virus replication through promoting autophagic degradation of virions.

Antiviral research

Zheng J,Deng Y,Wei Z,Zou H,Wen X,Cai J,Zhang S,Jia B,Lu M,Lu K,Lin Y

Mon May 01 00:00:00 UTC 2023

Lipid phosphatase SAC1 suppresses hepatitis B virus replication through promoting autophagic degradation of virions.

Antiviral research

Zheng J,Deng Y,Wei Z,Zou H,Wen X,Cai J,Zhang S,Jia B,Lu M,Lu K,Lin Y

Mon May 01 00:00:00 UTC 2023

ARMH3-mediated recruitment of PI4KB directs Golgi-to-endosome trafficking and activation of the antiviral effector STING.

Immunity

Fang R,Jiang Q,Jia X,Jiang Z

Tue Mar 14 00:00:00 UTC 2023

ARMH3-mediated recruitment of PI4KB directs Golgi-to-endosome trafficking and activation of the antiviral effector STING.

Immunity

Fang R,Jiang Q,Jia X,Jiang Z

Tue Mar 14 00:00:00 UTC 2023

Intercellular transfer of activated STING triggered by RAB22A-mediated non-canonical autophagy promotes antitumor immunity.

Cell research

Gao Y,Zheng X,Chang B,Lin Y,Huang X,Wang W,Ding S,Zhan W,Wang S,Xiao B,Huo L,Yu Y,Chen Y,Gong R,Wu Y,Zhang R,Zhong L,Wang X,Chen Q,Gao S,Jiang Z,Wei D,Kang T

Thu Dec 01 00:00:00 UTC 2022

Global mapping of Salmonella enterica-host protein-protein interactions during infection.

Cell host & microbe

Walch P,Selkrig J,Knodler LA,Rettel M,Stein F,Fernandez K,Viéitez C,Potel CM,Scholzen K,Geyer M,Rottner K,Steele-Mortimer O,Savitski MM,Holden DW,Typas A

Wed Aug 11 00:00:00 UTC 2021

Addiction to Golgi-resident PI4P synthesis in chromosome 1q21.3-amplified lung adenocarcinoma cells.

Proceedings of the National Academy of Sciences of the United States of America

Shi L,Tan X,Liu X,Yu J,Bota-Rabassedas N,Niu Y,Luo J,Xi Y,Zong C,Creighton CJ,Glenn JS,Wang J,Kurie JM

Tue Jun 22 00:00:00 UTC 2021

PtdIns4P restriction by hydrolase SAC1 decides specific fusion of autophagosomes with lysosomes.

Autophagy

Zhang H,Zhou J,Xiao P,Lin Y,Gong X,Liu S,Xu Q,Wang M,Ren H,Lu M,Wang Y,Zhu J,Xie Z,Li H,Lu K

Sun Aug 01 00:00:00 UTC 2021

The ER cholesterol sensor SCAP promotes CARTS biogenesis at ER-Golgi membrane contact sites.

The Journal of cell biology

Wakana Y,Hayashi K,Nemoto T,Watanabe C,Taoka M,Angulo-Capel J,Garcia-Parajo MF,Kumata H,Umemura T,Inoue H,Arasaki K,Campelo F,Tagaya M

Mon Jan 04 00:00:00 UTC 2021

Sensing of nutrients by CPT1C controls SAC1 activity to regulate AMPA receptor trafficking.

The Journal of cell biology

Casas M,Fadó R,Domínguez JL,Roig A,Kaku M,Chohnan S,Solé M,Unzeta M,Miñano-Molina AJ,Rodríguez-Álvarez J,Dickson EJ,Casals N

Mon Oct 05 00:00:00 UTC 2020

Sensing of nutrients by CPT1C controls SAC1 activity to regulate AMPA receptor trafficking.

The Journal of cell biology

Casas M,Fadó R,Domínguez JL,Roig A,Kaku M,Chohnan S,Solé M,Unzeta M,Miñano-Molina AJ,Rodríguez-Álvarez J,Dickson EJ,Casals N

Mon Oct 05 00:00:00 UTC 2020

The activity of Sac1 across ER-TGN contact sites requires the four-phosphate-adaptor-protein-1.

The Journal of cell biology

Venditti R,Masone MC,Rega LR,Di Tullio G,Santoro M,Polishchuk E,Serrano IC,Olkkonen VM,Harada A,Medina DL,La Montagna R,De Matteis MA

Mon Mar 04 00:00:00 UTC 2019

Sac1 Phosphoinositide Phosphatase Regulates Foam Cell Formation by Modulating SR-A Expression in Macrophages.

Biological & pharmaceutical bulletin

Nigorikawa K,Matsumura T,Sakamoto H,Morioka S,Kofuji S,Takasuga S,Hazeki K

Mon Nov 25 00:00:00 UTC 2019

An ER Assembly Line of AMPA-Receptors Controls Excitatory Neurotransmission and Its Plasticity.

Neuron

Schwenk J,Boudkkazi S,Kocylowski MK,Brechet A,Zolles G,Bus T,Costa K,Kollewe A,Jordan J,Bank J,Bildl W,Sprengel R,Kulik A,Roeper J,Schulte U,Fakler B

Wed Nov 20 00:00:00 UTC 2019

Phosphoinositide phosphatase Sac3 regulates the cell surface expression of scavenger receptor A and formation of lipid droplets in macrophages.

Experimental cell research

Morioka S,Nigorikawa K,Hazeki K,Ohmura M,Sakamoto H,Matsumura T,Takasuga S,Hazeki O

Tue Aug 15 00:00:00 UTC 2017

Regulation of CD44 expression and focal adhesion by Golgi phosphatidylinositol 4-phosphate in breast cancer.

Cancer science

Ijuin T,Takeuchi Y,Shimono Y,Fukumoto M,Tokuda E,Takenawa T

Fri Jul 01 00:00:00 UTC 2016

Regulation of CD44 expression and focal adhesion by Golgi phosphatidylinositol 4-phosphate in breast cancer.

Cancer science

Ijuin T,Takeuchi Y,Shimono Y,Fukumoto M,Tokuda E,Takenawa T

Fri Jul 01 00:00:00 UTC 2016

Phosphatidylinositol 4-phosphate in the Golgi apparatus regulates cell-cell adhesion and invasive cell migration in human breast cancer.

Cancer research

Tokuda E,Itoh T,Hasegawa J,Ijuin T,Takeuchi Y,Irino Y,Fukumoto M,Takenawa T

Sun Jun 01 00:00:00 UTC 2014

Phosphatidylinositol 4-phosphate in the Golgi apparatus regulates cell-cell adhesion and invasive cell migration in human breast cancer.

Cancer research

Tokuda E,Itoh T,Hasegawa J,Ijuin T,Takeuchi Y,Irino Y,Fukumoto M,Takenawa T

Sun Jun 01 00:00:00 UTC 2014

JNK3 couples the neuronal stress response to inhibition of secretory trafficking.

Science signaling

Yang G,Zhou X,Zhu J,Liu R,Zhang S,Coquinco A,Chen Y,Wen Y,Kojic L,Jia W,Cynader MS

Tue Jul 09 00:00:00 UTC 2013

JNK3 couples the neuronal stress response to inhibition of secretory trafficking.

Science signaling

Yang G,Zhou X,Zhu J,Liu R,Zhang S,Coquinco A,Chen Y,Wen Y,Kojic L,Jia W,Cynader MS

Tue Jul 09 00:00:00 UTC 2013

JNK3 couples the neuronal stress response to inhibition of secretory trafficking.

Science signaling

Yang G,Zhou X,Zhu J,Liu R,Zhang S,Coquinco A,Chen Y,Wen Y,Kojic L,Jia W,Cynader MS

Tue Jul 09 00:00:00 UTC 2013

JNK3 couples the neuronal stress response to inhibition of secretory trafficking.

Science signaling

Yang G,Zhou X,Zhu J,Liu R,Zhang S,Coquinco A,Chen Y,Wen Y,Kojic L,Jia W,Cynader MS

Tue Jul 09 00:00:00 UTC 2013

Bioinformatics

Protein Aliases: phosphatidylinositide phosphatase SAC1; Phosphatidylinositol-3-phosphatase SAC1; Phosphatidylinositol-4-phosphate phosphatase; polyphosphatidylinositol phosphatase; suppressor of actin 1; Suppressor of actin mutations 1-like protein

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Gene Aliases: KIAA0851; mKIAA0851; SAC1; Sac1p; SACM1L

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UniProt ID: (Human) Q9NTJ5, (Mouse) Q9EP69, (Rat) Q9ES21

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Entrez Gene ID: (Human) 22908, (Mouse) 83493, (Rat) 116482

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Function(s)

Process(es)

phosphatidylinositol dephosphorylation phosphatidylinositol biosynthetic process biological_process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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SACM1L Polyclonal Antibody

SACM1L Antibody (13033-1-AP) in ICC/IF

Product Details

13033-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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