Invitrogen

SALL1 Polyclonal Antibody

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-115864

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human SALL1(Accession Q9NSC2), corresponding to amino acid residues R4-E54.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2900498

Product Specific Information

Antibody detects endogenous levels of total SALL1.

Target Information

Sall1, which encodes a zinc finger protein, functions as a transcriptional repressor and interacts physically with histone deacetylase and other components of the chromatin remodeling NuRD complex. It is unknown whether the transcriptional repression is solely dependent on histone deacetylase activity. Gene expression profiling has identified Sall1 as a microglial signature gene. Microglia are the resident macrophages of the central nervous system (CNS). Sall1 is also expressed in abundance in the mesenchyme-derived structure from condensed mesenchyme, S-comma-shaped bodies, to renal tubules and podocytes. Sall1 has been identified as a key transcription factor in self-renewal renal progenitor cells. Sall1 is required to maintain the stemness of nephron progenitor cells by restraining their differentiation into renal vesicles. Defects in SALL1 are the cause of Townes-Brocks syndrome as well as bronchio-oto-renal syndrome. Heterozygous mutations of human SALL1 leading to Townes-Brocks syndrome features dysplastic ears, preaxial polydactyly, imperforate anus, and less commonly, kidney and heart anomalies (Kohlhase et al. 1998). Two transcript variants encoding different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: epididymis secretory protein Li 89; HSal1; sal-3; sal-like 1; Sal-like protein 1; Spalt-like transcription factor 1; Zinc finger protein 794; Zinc finger protein SALL1; Zinc finger protein Spalt-1; zinc finger protein Spalt-3

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Gene Aliases: HEL-S-89; HSAL1; Msal-3; Sal-1; SAL1; SALL1; TBS; ZNF794

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UniProt ID: (Human) Q9NSC2

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Entrez Gene ID: (Human) 6299, (Rat) 307740, (Mouse) 58198

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Function(s)
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding histone deacetylase activity protein binding beta-catenin binding sequence-specific DNA binding transcription regulatory region DNA binding metal ion binding RNA polymerase II transcription factor binding RNA polymerase II transcription coactivator activity enhancer sequence-specific DNA binding molecular_function chromatin binding nucleic acid binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter ureteric bud development branching involved in ureteric bud morphogenesis kidney development ventricular septum development mesenchymal to epithelial transition involved in metanephros morphogenesis transcription, DNA-templated heart development gonad development histone deacetylation olfactory nerve development olfactory bulb interneuron differentiation pituitary gland development neurogenesis positive regulation of Wnt signaling pathway adrenal gland development inductive cell-cell signaling somatic stem cell population maintenance outer ear morphogenesis embryonic digit morphogenesis negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter embryonic digestive tract development limb development olfactory bulb mitral cell layer development kidney epithelium development ureteric bud invasion neural tube closure negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis transcription from RNA polymerase II promoter biological_process olfactory bulb development neural tube development forelimb morphogenesis hindlimb morphogenesis positive regulation of neuron differentiation negative regulation of smoothened signaling pathway mesenchymal stem cell maintenance involved in metanephric nephron morphogenesis positive regulation of branching involved in ureteric bud morphogenesis regulation of neural precursor cell proliferation negative regulation of mesoderm development negative regulation of ectoderm development regulation of transcription, DNA-templated
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