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Product Details
28113-100UG
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to amino acids 165-183 (VKSNKSRLDQKSEGGKQLE) of human SAP30L conjugated to KLH at the N-terminus.
Conjugate
Form
Liquid
Concentration
0.5-1.0 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
A novel TGF- beta up-regulated mRNA species, the Sin3-associated protein 30-like, SAP30L has been identified. The predicted nuclear localization signal of SAP30L is sufficient for nuclear transport of the protein although mutating it does not completely remove SAP30L from the nuclei. By reason of its nuclear localization and close homology to SAP30 it is thought that SAP30L might have a role in recruiting the Sin3-histone deacetylase complex to specific co-repressor complexes in response to TGF-beta, leading to the silencing of proliferation-driving genes in the differentiating intestinal epithelial cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DKFZp667L2214; FLJ11526; FLJ23595; FLJ36497; HCV non-structural protein 4A-transactivated protein 2; Histone deacetylase complex subunit SAP30L; SAP30-like; Sin3 corepressor complex subunit SAP30L; Sin3-associated protein p30-like; Sin3A associated protein p30-like
Gene Aliases: NS4ATP2; SAP30L
UniProt ID: (Human) Q9HAJ7
Entrez Gene ID: (Human) 79685
Performance Guarantee
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