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Invitrogen
SARS-CoV-2 NSP5 Recombinant Rabbit Monoclonal Antibody (HL1367)
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FIGURE: 1 / 2
SARS-CoV-2 NSP5 Antibody (MA5-47017) in ICC/IF
Immunofluorescent analysis of SARS-CoV-2 NSP5 in mock and transfected 293T cells. Cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: SARS-CoV-2 (COVID-19) 3CLpro (nsp5) stained by SARS-CoV-2 (COVID-19) 3CLpro (nsp5) monoclonal antibody (Product # MA5-47017) diluted at 1:500. Blue: Hoechst 33342 staining.
Product Details
MA5-47017
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Virus
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
HL1367
Immunogen
Recombinant fragment of SARS-CoV-2 (COVID-19) 3CLpro (nsp5)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2938089
Product Specific Information
Store as concentrated solution.
Centrifuge briefly prior to opening vial.
Target Information
SARS-CoV-2 NSP5 is a non-structural protein in which the main protease targets RIG-I and mitochondrial antiviral signaling (MAVS) protein via two distinct mechanisms for inhibition. NSP5 cleaves off the 10 most-N-terminal amino acids from RIG-I and deprives it of the ability to activate MAVS, whereas NSP5 promotes the ubiquitination and proteosome-mediated degradation of MAVS. NSP5 potently inhibits interferon (IFN) induction by double-stranded RNA (dsRNA) in an enzyme-dependent manner.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: COVID-19 Envelope; SARS-CoV-2; SARS-CoV-2 Envelope
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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