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Invitrogen
SART3 Polyclonal Antibody
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FIGURE: 1 / 5
SART3 Antibody (PA5-88362) in IHC (P)
Immunohistochemistry analysis of SART3 in paraffin-embedded human colon carcinoma. Samples were incubated with SART3 Polyclonal antibody (Product # PA5-88362) using a dilution of 1:100 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.
Product Details
PA5-88362
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 664-963 of human SART3 (NP_0555211)
Conjugate
Form
Liquid
Concentration
0.42 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2804858
Product Specific Information
Immunogen sequence: AGPAGKCAAV DVEPPSKQKE KAASLKRDMP KVLHDSSKDS ITVFVSNLPY SMQEPDTKLR PLFEACGEVV QIRPIFSNRG DFRGYCYVEF KEEKSALQAL EMDRKSVEGR PMFVSPCVDK SKNPDFKVFR YSTSLEKHKL FISGLPFSCT KEELEEICKA HGTVKDLRLV TNRAGKPKGL AYVEYENESQ ASQAVMKMDG MTIKENIIKV AISNPPQRKV PEKPETRKAP GGPMLLPQTY GARGKGRTQL SLLPRALQRP SAAAPQAENG PAAAPAVAAP AATEAPKMSN ADFAKLFLRK; Positive Samples: U-87MG, A-431, HeLa, HepG2, Jurkat; Cellular Location: Cajal body, Cytoplasm, Nucleus, Nucleus speckle, nucleoplasm
Target Information
The protein encoded by this gene is an RNA-binding nuclear protein that is a tumor-rejection antigen. This antigen possesses tumor epitopes capable of inducing HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes in cancer patients and may be useful for specific immunotherapy. This gene product is found to be an important cellular factor for HIV-1 gene expression and viral replication. It also associates transiently with U6 and U4/U6 snRNPs during the recycling phase of the spliceosome cycle. This encoded protein is thought to be involved in the regulation of mRNA splicing.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: HIV-1 Tat-interacting protein of 110kDa; hSART-3; MGC138188; mSART-3; p110 nuclear RNA-binding protein; SART-3; squamous cell carcinoma antigen recognized by T cells 3; Squamous cell carcinoma antigen recognized by T-cells 3; Tat-interacting protein of 110 kDa; Tip110; Tumor-rejection antigen SART3
Gene Aliases: AU045857; DSAP1; KIAA0156; mKIAA0156; P100; p110; p110(nrb); RP11-13G14; SART3; TIP110
UniProt ID: (Human) Q15020, (Mouse) Q9JLI8
Entrez Gene ID: (Human) 9733, (Mouse) 53890, (Rat) 304582
spliceosomal tri-snRNP complex assembly
spliceosomal complex assembly
spliceosomal snRNP assembly
mRNA splicing, via spliceosome
cell morphogenesis
nucleosome assembly
regulation of gene expression
homeostasis of number of cells
hematopoietic stem cell proliferation
positive regulation of histone deubiquitination
RNA processing
mRNA processing
RNA splicing
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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