Proteintech

SAT1 Polyclonal Antibody

SAT1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 5

SAT1 Antibody (10708-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using (Product # 10708-1-AP) (SAT1 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

SAT1 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

10708-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:200-1:1,000

View 13 publications 13 publications

Immunohistochemistry (IHC)

View 4 publications 4 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

SAT1 Fusion Protein Ag1154 (1-171 aa encoded by BC008424)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.17 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MAKFVIRPA TAADCSDILR LIKELAKYEY MEEQVILTEK DLLEDGFGEH PFYHCLVAEV PKEHWTPEGH SIVGFAMYYF TYDPWIGKLL YLEDFFVMSD YRGFGIGSEI LKNLSQVAMR CRCSSMHFLV AEWNEPSINF YKRRGASDLS SEEGWRLFKI DKEYLLKMAT EE (1-171 aa encoded by BC008424)

Target Information

Spermidine/spermine-N1-acetyltransferase (SSAT1) is a short-lived polyamine catabolic enzyme which catalyzes the acetylation of polyamines. This highly regulated enzyme allows a fine attenuation of the intracellular concentration of polyamines. Induction of SSAT1 plays an important role in polyamine homoeostasis, since the N1-acetylated polyamines can be excreted or oxidized by acetylpolyamine oxidase.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

The oncogenic properties of the EWSR1::CREM fusion gene are associated with polyamine metabolism.

Scientific reports

Kaprio H,Siddiqui A,Saustila L,Heuser VD,Gardberg M

Sat Mar 25 00:00:00 UTC 2023

A role of GABA_A receptor α1 subunit in the hippocampus for rapid-acting antidepressant-like effects of ketamine.

Neuropharmacology

Tang XH,Diao YG,Ren ZY,Zang YY,Zhang GF,Wang XM,Duan GF,Shen JC,Hashimoto K,Zhou ZQ,Yang JJ

Wed Mar 01 00:00:00 UTC 2023

Inhibition of YAP by lenvatinib in endothelial cells increases blood pressure through ferroptosis.

Biochimica et biophysica acta. Molecular basis of disease

Liang C,Zhu D,Xia W,Hong Z,Wang QS,Sun Y,Yang YC,Han SQ,Tang LL,Lou J,Wu MM,Zhang ZR

Sun Jan 01 00:00:00 UTC 2023

Urea cycle activation triggered by host-microbiota maladaptation driving colorectal tumorigenesis.

Cell metabolism

Chen H,Tong T,Lu SY,Ji L,Xuan B,Zhao G,Yan Y,Song L,Zhao L,Xie Y,Leng X,Zhang X,Cui Y,Chen X,Xiong H,Yu T,Li X,Sun T,Wang Z,Chen J,Chen YX,Hong J,Fang JY

Tue Apr 04 00:00:00 UTC 2023

Urea cycle activation triggered by host-microbiota maladaptation driving colorectal tumorigenesis.

Cell metabolism

Chen H,Tong T,Lu SY,Ji L,Xuan B,Zhao G,Yan Y,Song L,Zhao L,Xie Y,Leng X,Zhang X,Cui Y,Chen X,Xiong H,Yu T,Li X,Sun T,Wang Z,Chen J,Chen YX,Hong J,Fang JY

Tue Apr 04 00:00:00 UTC 2023

Urea cycle activation triggered by host-microbiota maladaptation driving colorectal tumorigenesis.

Cell metabolism

Chen H,Tong T,Lu SY,Ji L,Xuan B,Zhao G,Yan Y,Song L,Zhao L,Xie Y,Leng X,Zhang X,Cui Y,Chen X,Xiong H,Yu T,Li X,Sun T,Wang Z,Chen J,Chen YX,Hong J,Fang JY

Tue Apr 04 00:00:00 UTC 2023

Urea cycle activation triggered by host-microbiota maladaptation driving colorectal tumorigenesis.

Cell metabolism

Chen H,Tong T,Lu SY,Ji L,Xuan B,Zhao G,Yan Y,Song L,Zhao L,Xie Y,Leng X,Zhang X,Cui Y,Chen X,Xiong H,Yu T,Li X,Sun T,Wang Z,Chen J,Chen YX,Hong J,Fang JY

Tue Apr 04 00:00:00 UTC 2023

Activation of SSAT1/ALOX15 Axis Aggravates Cerebral Ischemia/Reperfusion Injury via Triggering Neuronal Ferroptosis.

Neuroscience

Zhao J,Wu Y,Liang S,Piao X

Tue Mar 01 00:00:00 UTC 2022

Activation of SSAT1/ALOX15 Axis Aggravates Cerebral Ischemia/Reperfusion Injury via Triggering Neuronal Ferroptosis.

Neuroscience

Zhao J,Wu Y,Liang S,Piao X

Tue Mar 01 00:00:00 UTC 2022

Urea transporter B downregulates polyamines levels in melanoma B16 cells via p53 activation.

Biochimica et biophysica acta. Molecular cell research

Li J,Sun Y,Yan R,Wu X,Zou H,Meng Y

Sun May 01 00:00:00 UTC 2022

DEHP induces ferroptosis in testes via p38α-lipid ROS circulation and destroys the BTB integrity.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

Yang L,Jiang L,Sun X,Li J,Wang N,Liu X,Yao X,Zhang C,Deng H,Wang S,Yang G

Wed Jun 01 00:00:00 UTC 2022

FTH1- and SAT1-Induced Astrocytic Ferroptosis Is Involved in Alzheimer's Disease: Evidence from Single-Cell Transcriptomic Analysis.

Pharmaceuticals (Basel, Switzerland)

Dang Y,He Q,Yang S,Sun H,Liu Y,Li W,Tang Y,Zheng Y,Wu T

Thu Sep 22 00:00:00 UTC 2022

Progesterone and interferon tau regulate expression of polyamine enzymes during the ovine peri-implantation period†.

Biology of reproduction

Halloran KM,Stenhouse C,Moses RM,Seo H,Johnson GA,Wu G,Bazer FW

Tue May 17 00:00:00 UTC 2022

ASMTL-AS1 impedes the malignant progression of lung adenocarcinoma by regulating SAT1 to promote ferroptosis.

Pathology international

Sui X,Hu N,Zhang Z,Wang Y,Wang P,Xiu G

Mon Nov 01 00:00:00 UTC 2021

Exogenous spermidine affects polyamine metabolism in the mouse hypothalamus.

Open life sciences

Jiang D,Mo G,Jiang Y,Kang B

Tue Apr 06 00:00:00 UTC 2021

Knockdown of SSATX, an alternative splicing variant of the SAT1 gene, promotes melanoma progression.

Gene

Yang Q,Deng Y,Xu Y,Ding N,Wang C,Zhao X,Lou X,Li Y,Zhao H,Fang X

Sun Oct 20 00:00:00 UTC 2019

Effects of berberine on tumor growth and intestinal permeability in HCT116 tumor-bearing mice using polyamines as targets.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Wu YY,Li TM,Zang LQ,Liu B,Wang GX

Thu Nov 01 00:00:00 UTC 2018

Effects of berberine on tumor growth and intestinal permeability in HCT116 tumor-bearing mice using polyamines as targets.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Wu YY,Li TM,Zang LQ,Liu B,Wang GX

Thu Nov 01 00:00:00 UTC 2018

SLC26A Gene Family Participate in pH Regulation during Enamel Maturation.

PloS one

Yin K,Lei Y,Wen X,Lacruz RS,Soleimani M,Kurtz I,Snead ML,White SN,Paine ML

Sun Jun 26 00:00:00 UTC 2016

SLC26A Gene Family Participate in pH Regulation during Enamel Maturation.

PloS one

Yin K,Lei Y,Wen X,Lacruz RS,Soleimani M,Kurtz I,Snead ML,White SN,Paine ML

Sun Jun 26 00:00:00 UTC 2016

Polyamine pathway contributes to the pathogenesis of Parkinson disease.

Proceedings of the National Academy of Sciences of the United States of America

Lewandowski NM,Ju S,Verbitsky M,Ross B,Geddie ML,Rockenstein E,Adame A,Muhammad A,Vonsattel JP,Ringe D,Cote L,Lindquist S,Masliah E,Petsko GA,Marder K,Clark LN,Small SA

Tue Sep 28 00:00:00 UTC 2010

Polyamine pathway contributes to the pathogenesis of Parkinson disease.

Proceedings of the National Academy of Sciences of the United States of America

Lewandowski NM,Ju S,Verbitsky M,Ross B,Geddie ML,Rockenstein E,Adame A,Muhammad A,Vonsattel JP,Ringe D,Cote L,Lindquist S,Masliah E,Petsko GA,Marder K,Clark LN,Small SA

Tue Sep 28 00:00:00 UTC 2010

Relationships between hematopoiesis and hepatogenesis in the midtrimester fetal liver characterized by dynamic transcriptomic and proteomic profiles.

PloS one

Guo Y,Zhang X,Huang J,Zeng Y,Liu W,Geng C,Li KW,Yang D,Wu S,Wei H,Han Z,Qian X,Jiang Y,He F

Wed Oct 28 00:00:00 UTC 2009

Relationships between hematopoiesis and hepatogenesis in the midtrimester fetal liver characterized by dynamic transcriptomic and proteomic profiles.

PloS one

Guo Y,Zhang X,Huang J,Zeng Y,Liu W,Geng C,Li KW,Yang D,Wu S,Wei H,Han Z,Qian X,Jiang Y,He F

Wed Oct 28 00:00:00 UTC 2009

Bioinformatics

Protein Aliases: Diamine acetyltransferase 1; diamine N-acetyltransferase 1; EC 2.3.1.57; Polyamine N-acetyltransferase 1; Putrescine acetyltransferase; Spermidine / spermine N1-acyltransferase (diamine acetyltransferase); Spermidine/spermine N(1)-acetyltransferase 1; spermidine/spermine N1-acetyltransferase alpha; SSAT; SSAT-1

View more View less

Gene Aliases: AA617398; Ab2-402; DC21; KFSD; KFSDX; SAT; SAT1; SSAT; SSAT-1

View more View less

UniProt ID: (Human) P21673, (Mouse) P48026

View more View less

Entrez Gene ID: (Human) 6303, (Mouse) 20229, (Rat) 302642

View more View less

Function(s)

diamine N-acetyltransferase activity protein binding N-acetyltransferase activity transferase activity transferase activity, transferring acyl groups spermidine binding

Process(es)

angiogenesis polyamine biosynthetic process putrescine catabolic process regulation of cell proliferation polyamine metabolic process polyamine catabolic process spermidine acetylation spermine catabolic process spermine acetylation

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more

SAT1 Polyclonal Antibody

SAT1 Antibody (10708-1-AP) in IHC (P)

Product Details

10708-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

We're here to help

Your items have has been added!