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SCF Polyclonal Antibody

SCF Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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SCF Antibody (26582-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human kidney tissue slide using 26582-1-AP (SCF antibody) at dilution of 1:200 (under 10x lens) heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

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Product Details

26582-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 4 publications 4 publications

Immunohistochemistry (IHC)

View 4 publications 4 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

SCF Fusion Protein Ag25075 (28-214 aa encoded by BC074725)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.27 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: ICRNRVTNN VKDVTKLVAN LPKDYMITLK YVPGMDVLPS HCWISEMVVQ LSDSLTDLLD KFSNISEGLS NYSIIDKLVN IVDDLVECVK ENSSKDLKKS FKSPEPRLFT PEEFFRIFNR SIDAFKDFVV ASETSDCVVS STLSPEKDSR VSVTKPFMLP PVAASSLRND SSSSNRKAKN PPGDSSLH (28-214 aa encoded by BC074725 )

Target Information

Stem cell factor (SCF) is the ligand of the c-Kit oncogene and is expressed by various structural and inflammatory cells in the airways. Binding of SCF by the c-Kit receptor leads to homodimerization of the receptor and the activation of signalling pathways such as PI-3, PLC-gamma, Jak/STAT, and MAP kinase pathways. SCF expression leads to the induction of mast cell survival and the expression and release of histamine, pro-inflammatory cytokines and chemokines. The inhibition of the SCF/c-Kit pathway leads to a decrease in histamine levels, mast cell and eosinophil infiltration, IL-4 production and airway hyperresponsiveness, suggesting this pathway may be a useful therapeutic target in inflammatory diseases such as asthma. At least two isoforms of SCF are known to exist.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Increased Chymase-Positive Mast Cells in High-Grade Mucoepidermoid Carcinoma of the Parotid Gland.

International journal of molecular sciences

Nishimura H,Jin D,Kinoshita I,Taniuchi M,Higashino M,Terada T,Takai S,Kawata R

Fri May 05 00:00:00 UTC 2023

Arctiin alleviates functional constipation by enhancing intestinal motility in mice.

Experimental and therapeutic medicine

Wang Y,Jiang H,Wang L,Gan H,Xiao X,Huang L,Li W,Li Z

Mon May 01 00:00:00 UTC 2023

Arctiin alleviates functional constipation by enhancing intestinal motility in mice.

Experimental and therapeutic medicine

Wang Y,Jiang H,Wang L,Gan H,Xiao X,Huang L,Li W,Li Z

Mon May 01 00:00:00 UTC 2023

Shengxuening Extracted from Silkworm Excrement Mitigates Myelosuppression via SCF-Mediated JAK2/STAT3 Signaling.

Chemistry & biodiversity

Ding L,Tan Y,Xu L,Jin Y,Liu Y,Tu H,Zhang D,Wu B,Chen Y,Shen H,Liu L,Huang T,Zhou F

Tue Jun 01 00:00:00 UTC 2021

miR-128 participates in the pathogenesis of chronic constipation by regulating the p38α/M-CSF inflammatory signaling pathway.

American journal of physiology. Gastrointestinal and liver physiology

Hong Y,Ren X,Liu W,Sun K,Chen B,Liu B,Yu X,Chen Q,Qian Q,Xie X,Jiang C

Fri Oct 01 00:00:00 UTC 2021

miR-128 participates in the pathogenesis of chronic constipation by regulating the p38α/M-CSF inflammatory signaling pathway.

American journal of physiology. Gastrointestinal and liver physiology

Hong Y,Ren X,Liu W,Sun K,Chen B,Liu B,Yu X,Chen Q,Qian Q,Xie X,Jiang C

Fri Oct 01 00:00:00 UTC 2021

Increase in Chymase-Positive Mast Cells in Recurrent Pleomorphic Adenoma and Carcinoma Ex Pleomorphic Adenoma of the Parotid Gland.

International journal of molecular sciences

Kinoshita I,Jin D,Higashino M,Terada T,Kurisu Y,Takai S,Kawata R

Tue Nov 23 00:00:00 UTC 2021

High expression of KITLG is a new hallmark activating the MAPK pathway in type A and AB thymoma.

Thoracic cancer

Yang Z,Liu S,Wang Y,Chen Y,Zhang P,Liu Y,Zhang H,Zhang P,Tao Z,Xiong K

Wed Jul 01 00:00:00 UTC 2020

Bioinformatics

Protein Aliases: C-kit ligand; cloud gray; DKFZp686F2250; familial progressive hyperpigmentation 2; grizzle-belly; H-SCF; Hematopoietic growth factor KL; Kit ligand; kit-ligand; M-SCF; Mast cell growth factor; MGF; SCF; Steel factor; steel factor/kit ligand; Stem cell factor; stem cell factor KL-1

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Gene Aliases: blz; Clo; Con; contrasted; DCUA; DFNA69; FPH2; FPHH; Gb; Kitl; KITLG; KL-1; MGF; SCF; SF; SHEP7; Sl; SLF

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UniProt ID: (Human) P21583, (Mouse) P20826, (Rat) P21581

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Entrez Gene ID: (Human) 4254, (Mouse) 17311, (Rat) 60427

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Function(s)

Ras guanyl-nucleotide exchange factor activity cytokine activity stem cell factor receptor binding protein binding growth factor activity phosphatidylinositol-4,5-bisphosphate 3-kinase activity

Process(es)

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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SCF Polyclonal Antibody

SCF Antibody (26582-1-AP) in IHC (P)

Product Details

26582-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Species Reactivity

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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