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Invitrogen
SCIMP Monoclonal Antibody (NVL-07)
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SCIMP Antibody (MA5-28633) in WB
Western Blot analysis of SCIMP using SCIMP Monoclonal Antibody (NVL-07) (Product # MA5-28633) on lysates of human SCIMP transfectants under reducing and non-reducing conditions. Nitrocellulose membrane was probed with 2µg/mL of mouse monoclonal antibody followed by an anti-mouse secondary antibody. SCIMP was detected around 17-22kDa.
Product Details
MA5-28633
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
NVL-07
Immunogen
Human SCIMP (intracellular region)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
15mM sodium azide
Storage conditions
4°C, do not freeze
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2745592
Product Specific Information
This antibody recognizes intracellular part of human transmembrane adaptor SCIMP. This protein of 17 kDa predicted Mw migrates as a 22 kDa band on SDS PAGE.
Target Information
SCIMP (SLP adaptor and Csk interacting membrane protein), also known as Nvl, is a palmitoylated transmembrane adaptor protein expressed in professional antigen presenting cells, most prominently in the lymph nodes and spleen. It is associated with tetraspanin-enriched microdomains (together with MHC II). There is a close relationship between SCIMP and tyrosinkinase Lyn, which is constitutively bound to it by its SH3 domain. After MHC II-mediated stimulation in the immunological synapse SCIMP becomes phosphorylated at several tyrosine residues and provides docking sites for Grb2 and SLP65 or SLP76 adaptors transducing the signal downstream, as well as for the kinase Csk with modulatory roles.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DTFT5783; SLP adapter and CSK-interacting membrane protein; SLP65/SLP76, Csk-interacting membrane protein; transmembrane protein C17orf87
Gene Aliases: C17orf87; SCIMP; UNQ5783; UNQ5783/PRO16090
UniProt ID: (Human) Q6UWF3
Entrez Gene ID: (Human) 388325
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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