Proteintech

SCIN Polyclonal Antibody

SCIN Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 4

SCIN Antibody (11579-1-AP) in ICC/IF

Immunofluorescent analysis of HepG2 cells, using SCIN antibody 11579-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IGG (red).

SCIN Antibody in Immunohistochemistry (Paraffin) (IHC (P))

SCIN Antibody in Immunoprecipitation (IP)

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Product Details

11579-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:10-1:100

View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

SCIN Fusion Protein Ag2168 (1-357 aa encoded by BC021090)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.23 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MARELYHEE FARAGKQAGL QVWRIEKLEL VPVPQSAHGD FYVGDAYLVL HTAKTSRGFT YRLHFWLGKE CSQDESTAAA IFTVQMDDYL GGKPVQNREL QGYESNDFVS YFKGGLKYKA GGVASGLNHV LTNDLTAKRL LHVKGRRVVR ATEVPLSWDS FNKGDCFIID LGTEIYQWCG SSCNKYERLK ANQVATGIRY NERKGRSELI VVEEGSEPSE LIKVLGEKPE LPDGGDDDDI IADISNRKMA KLYMVSDASG SMRVTVVAEE NPFSMAMLLS EECFILDHGA AKQIFVWKGK DANPQERKAA MKTAEEFLQQ MNYSKNTQIQ VLPEGGETPI FKQFFKDWRD KDQSDGFG (1-357 aa encoded by BC021090)

Target Information

The SCIN gene, also known as scinderin, encodes for a calcium-dependent actin filament-severing protein that is involved in the regulation of the cytoskeleton. It plays a significant role in actin filament dynamics, influencing cellular processes such as cell shape, motility, secretion, and division. SCIN has been identified as a novel oncogene, with its abnormal expression strongly correlated to various cancers, including glioma and uterine corpus endometrial carcinoma. Specific mutations like S673F and S381Y in SCIN are linked with poor prognosis and are potential targets for cancer diagnosis, prognosis, and treatment strategies.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Synaptic proteomics reveal distinct molecular signatures of cognitive change and C9ORF72 repeat expansion in the human ALS cortex.

Acta neuropathologica communications

Laszlo ZI,Hindley N,Sanchez Avila A,Kline RA,Eaton SL,Lamont DJ,Smith C,Spires-Jones TL,Wishart TM,Henstridge CM

Sat Oct 29 00:00:00 UTC 2022

Loss of scinderin decreased expression of epidermal growth factor receptor and promoted apoptosis of castration-resistant prostate cancer cells.

FEBS open bio

Lai X,Su W,Zhao H,Yang S,Zeng T,Wu W,Wang D

Tue May 01 00:00:00 UTC 2018

Loss of scinderin decreased expression of epidermal growth factor receptor and promoted apoptosis of castration-resistant prostate cancer cells.

FEBS open bio

Lai X,Su W,Zhao H,Yang S,Zeng T,Wu W,Wang D

Tue May 01 00:00:00 UTC 2018

Loss of scinderin decreased expression of epidermal growth factor receptor and promoted apoptosis of castration-resistant prostate cancer cells.

FEBS open bio

Lai X,Su W,Zhao H,Yang S,Zeng T,Wu W,Wang D

Tue May 01 00:00:00 UTC 2018

Loss of scinderin decreased expression of epidermal growth factor receptor and promoted apoptosis of castration-resistant prostate cancer cells.

FEBS open bio

Lai X,Su W,Zhao H,Yang S,Zeng T,Wu W,Wang D

Tue May 01 00:00:00 UTC 2018

Bioinformatics

Protein Aliases: Adseverin; Gelsolin-like protein; Scinderin

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Gene Aliases: adseverin; AW545522; KIAA1905; SCIN; Scind

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UniProt ID: (Human) Q9Y6U3, (Mouse) Q60604

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Entrez Gene ID: (Human) 85477, (Rat) 298975, (Mouse) 20259

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Function(s)

phosphatidylserine binding actin binding calcium ion binding 1-phosphatidylinositol binding phosphatidylinositol-4,5-bisphosphate binding actin filament binding

Process(es)

negative regulation of cell proliferation positive regulation of apoptotic process positive regulation of megakaryocyte differentiation actin filament severing sequestering of actin monomers positive regulation of actin nucleation actin filament capping calcium ion regulated exocytosis regulation of chondrocyte differentiation actin nucleation positive regulation of secretion

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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SCIN Polyclonal Antibody

SCIN Antibody (11579-1-AP) in ICC/IF

Product Details

11579-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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