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Abnova
SCIN Polyclonal Antibody, MaxPab™
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Product Details
H00085477-B01P
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
SCIN (NP_149119.1, 1 a.a. approximately 468 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
0.5-1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MAKLYMVSDA SGSMRVTVVA EENPFSMAML LSEECFILDH GAAKQIFVWK GKDANPQERK AAMKTAEEFL QQMNYSKNTQ IQVLPEGGET PIFKQFFKDW RDKDQSDGFG KVYVTEKVAQ IKQIPFDASK LHSSPQMAAQ HNMVDDGSGK VEIWRVENNG RIQVDQNSYG EFYGGDCYII LYTYPRGQII YTWQGANATR DELTTSAFLT VQLDRSLGGQ AVQIRVSQGK EPVHLLSLFK DKPLIIYKNG TSKKGGQAPA PPTRLFQVRR NLASITRIVE VDVDANSLNS NDVFVLKLPQ NSGYIWVGKG ASQEEEKGAE YVASVLKCKT LRIQEGEEPE EFWNSLGGKK DYQTSPLLET QAEDHPPRLY GCSNKTGRFV IEEIPGEFTQ DDLAEDDVML LDAWEQIFIW IGKDANEVEK KESLKSAKMY LETDPSGRDK RTPIVIIKQG HEPPTFTGWF LGWDSSKW
Target Information
The SCIN gene, also known as scinderin, encodes for a calcium-dependent actin filament-severing protein that is involved in the regulation of the cytoskeleton. It plays a significant role in actin filament dynamics, influencing cellular processes such as cell shape, motility, secretion, and division. SCIN has been identified as a novel oncogene, with its abnormal expression strongly correlated to various cancers, including glioma and uterine corpus endometrial carcinoma. Specific mutations like S673F and S381Y in SCIN are linked with poor prognosis and are potential targets for cancer diagnosis, prognosis, and treatment strategies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Adseverin; Scinderin
Gene Aliases: KIAA1905; SCIN
UniProt ID: (Human) Q9Y6U3
Entrez Gene ID: (Human) 85477
negative regulation of cell proliferation
calcium ion regulated exocytosis
regulation of chondrocyte differentiation
sequestering of actin monomers
positive regulation of apoptotic process
actin nucleation
positive regulation of megakaryocyte differentiation
actin filament severing
positive regulation of secretion
positive regulation of actin nucleation
actin filament capping
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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