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Invitrogen
SCIN Polyclonal Antibody
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Product Details
PA5-112705
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human Adseverin protein (556-703AA)
Conjugate
Form
Liquid
Concentration
7 mg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.03% ProClin 300
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Wet ice
RRID
AB_2867440
Target Information
The SCIN gene, also known as scinderin, encodes for a calcium-dependent actin filament-severing protein that is involved in the regulation of the cytoskeleton. It plays a significant role in actin filament dynamics, influencing cellular processes such as cell shape, motility, secretion, and division. SCIN has been identified as a novel oncogene, with its abnormal expression strongly correlated to various cancers, including glioma and uterine corpus endometrial carcinoma. Specific mutations like S673F and S381Y in SCIN are linked with poor prognosis and are potential targets for cancer diagnosis, prognosis, and treatment strategies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Adseverin; Gelsolin-like protein; Scinderin
Gene Aliases: adseverin; AW545522; KIAA1905; SCIN
UniProt ID: (Human) Q9Y6U3, (Mouse) Q60604
Entrez Gene ID: (Human) 85477, (Mouse) 20259
negative regulation of cell proliferation
sequestering of actin monomers
positive regulation of apoptotic process
positive regulation of megakaryocyte differentiation
actin filament severing
positive regulation of actin nucleation
actin filament capping
calcium ion regulated exocytosis
regulation of chondrocyte differentiation
actin nucleation
positive regulation of secretion
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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