Proteintech

SCLT1 Polyclonal Antibody

SCLT1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 4

SCLT1 Antibody (14875-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded human colon cancer tissue slide using (Product # 14875-1-AP) (SCLT1 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

SCLT1 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

14875-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:3,000

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:200

Immunocytochemistry (ICC/IF)

Assay-dependent

View 6 publications 6 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

SCLT1 Fusion Protein Ag6646 (1-79 aa encoded by BC064428)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.18 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MAAEIDFLR EQNRRLNEDF RRYQMESFSK YSSVQKAVCQ GEGDDTFENL VFDQSFLAPL VTEYDKHLGE LNGQLKYYQA (1-79 aa encoded by BC064428 )

Target Information

Adapter protein that links SCN10A to clathrin. Regulates SCN10A channel activity, possibly by promoting channel internalization.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

A stress-induced cilium-to-PML-NB route drives senescence initiation.

Nature communications

Ma X,Zhang Y,Zhang Y,Zhang X,Huang Y,He K,Chen C,Hao J,Zhao D,LeBrasseur NK,Kirkland JL,Chini EN,Wei Q,Ling K,Hu J

Mon Apr 03 00:00:00 UTC 2023

A stress-induced cilium-to-PML-NB route drives senescence initiation.

Nature communications

Ma X,Zhang Y,Zhang Y,Zhang X,Huang Y,He K,Chen C,Hao J,Zhao D,LeBrasseur NK,Kirkland JL,Chini EN,Wei Q,Ling K,Hu J

Mon Apr 03 00:00:00 UTC 2023

Ciliopathy protein HYLS1 coordinates the biogenesis and signaling of primary cilia by activating the ciliary lipid kinase PIPKIγ.

Science advances

Chen C,Xu Q,Zhang Y,Davies BA,Huang Y,Katzmann DJ,Harris PC,Hu J,Ling K

Tue Jun 01 00:00:00 UTC 2021

ASK1-Mediated Phosphorylation Blocks HDAC6 Ubiquitination and Degradation to Drive the Disassembly of Photoreceptor Connecting Cilia.

Developmental cell

Ran J,Liu M,Feng J,Li H,Ma H,Song T,Cao Y,Zhou P,Wu Y,Yang Y,Yang Y,Yu F,Guo H,Zhang L,Xie S,Li D,Gao J,Zhang X,Zhu X,Zhou J

Mon May 04 00:00:00 UTC 2020

TALPID3 and ANKRD26 selectively orchestrate FBF1 localization and cilia gating.

Nature communications

Yan H,Chen C,Chen H,Hong H,Huang Y,Ling K,Hu J,Wei Q

Mon May 04 00:00:00 UTC 2020

Phosphorylation of CEP83 by TTBK2 is necessary for cilia initiation.

The Journal of cell biology

Lo CH,Lin IH,Yang TT,Huang YC,Tanos BE,Chou PC,Chang CW,Tsay YG,Liao JC,Wang WJ

Mon Oct 07 00:00:00 UTC 2019

Phosphorylation of CEP83 by TTBK2 is necessary for cilia initiation.

The Journal of cell biology

Lo CH,Lin IH,Yang TT,Huang YC,Tanos BE,Chou PC,Chang CW,Tsay YG,Liao JC,Wang WJ

Mon Oct 07 00:00:00 UTC 2019

The CEP19-RABL2 GTPase Complex Binds IFT-B to Initiate Intraflagellar Transport at the Ciliary Base.

Developmental cell

Kanie T,Abbott KL,Mooney NA,Plowey ED,Demeter J,Jackson PK

Mon Jul 10 00:00:00 UTC 2017

Phosphatidylinositol phosphate kinase PIPKIγ and phosphatase INPP5E coordinate initiation of ciliogenesis.

Nature communications

Xu Q,Zhang Y,Wei Q,Huang Y,Hu J,Ling K

Fri Feb 26 00:00:00 UTC 2016

Phosphatidylinositol phosphate kinase PIPKIγ and phosphatase INPP5E coordinate initiation of ciliogenesis.

Nature communications

Xu Q,Zhang Y,Wei Q,Huang Y,Hu J,Ling K

Fri Feb 26 00:00:00 UTC 2016

Bioinformatics

Protein Aliases: Sodium channel and clathrin linker 1; Sodium channel-associated protein 1

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Gene Aliases: 2610207F23Rik; 4931421F20Rik; CAP-1A; CAP1A; SAP1; SCLT1

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UniProt ID: (Human) Q96NL6, (Mouse) G5E861

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Entrez Gene ID: (Human) 132320, (Mouse) 67161

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Function(s)

protein C-terminus binding sodium channel regulator activity clathrin binding

Process(es)

cilium assembly clustering of voltage-gated sodium channels

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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SCLT1 Polyclonal Antibody

SCLT1 Antibody (14875-1-AP) in IHC (P)

Product Details

14875-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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