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Alomone Labs, LTD
SCN2A (NaV1.2) Polyclonal Antibody
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SCN2A (NaV1.2) Antibody (ASC-002-200UL) in IHC
Expression of NaV1.2 in mouse hippocampus - Immunohistochemical staining of mouse hippocampus using Anti-SCN2A (NaV1.2) Antibody (#ASC-002 ). A. NaV1.2 (red) is present in dendrites of pyramidal neurons in the CA3 region. B. Staining ofinterneurons in the pyramidal layer with mouse Anti-Parvalbumin (green) demonstrates the restriction of NaV1.2 to dendrites (arrows) extending from the pyramidal layer (P). C... View More
Product Details
ASC-002-200UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
(C)ASAESRDFSGAGGIGVFSE, corresponding to amino acid residues 467-485 of rat NaV1.2, Intracellular loop between domains I and II
Conjugate
Form
Lyophilized
Concentration
0.8 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 1% BSA
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Target Information
Voltage-gated sodium channels are selective ion channels that regulate the permeability of sodium ions in excitable cells. During the propagation of an action potential, sodium channels allow an influx of sodium ions, which rapidly depolarize the cell. The alpha subunits of sodium channels type I and III are predominantly expressed in neuronal cell bodies and proximal processes, while type II alpha subunits are more abundant along axons. The beta1 subunit of sodium channel type I is expressed in brain, skeletal and cardiac muscle. In the brain, beta1 and beta2 are highly expressed in Purkinje cells, and beta1 is also expressed in the pyramidal cells of the deep cerebellar nuclei. Impaired voltage-gated sodium channels lead to a number of diseases including myotonia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: alternative product; Brain Type II; HBSC II; RIIA sodium channel protein; Sodium channel protein brain II subunit alpha; Sodium channel protein type 2 subunit alpha; Sodium channel protein type II subunit alpha; sodium channel protein, brain II subunit alpha; sodium channel protein, brain type 2 alpha subunit; sodium channel voltage-gated type II alpha polypeptide; sodium channel, voltage gated, type II alpha subunit; sodium channel, voltage-gated, type 2, alpha 1 polypeptide; sodium channel, voltage-gated, type 2, alpha 1 subunit; sodium channel, voltage-gated, type II, alpha 1; sodium channel, voltage-gated, type II, alpha 1 polypeptide; sodium channel, voltage-gated, type II, alpha 2 polypeptide; sodium channel, voltage-gated, type II, alpha polypeptide 1; sodium channel, voltage-gated, type II, alpha subunit; voltage-gated sodium channel subtype II; Voltage-gated sodium channel subunit alpha Nav1.2; voltage-gated sodium channel type II alpha subunit
Gene Aliases: 6430408L10; A230052E19Rik; BFIC3; BFIS3; BFNIS; EIEE11; HBA; HBSCI; HBSCII; Na(v)1.2; NAC2; NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN; SCN2A; SCN2A1; SCN2A2; ScpII
UniProt ID: (Human) Q99250, (Rat) P04775, (Mouse) B1AWN6
Entrez Gene ID: (Human) 6326, (Rat) 24766, (Mouse) 110876
sodium ion transport
nervous system development
intrinsic apoptotic signaling pathway in response to osmotic stress
neuronal action potential
regulation of ion transmembrane transport
sodium ion transmembrane transport
neuron apoptotic process
membrane depolarization during action potential
myelination
regulation of postsynaptic membrane potential
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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