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Proteintech
SCN4B Polyclonal Antibody
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Product Details
55438-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide
Conjugate
Form
Liquid
Concentration
0.39 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Target Information
The SCN4B protein modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation. The protein has been found to be expressed at a high level in dorsal root ganglia, at a lower level in brain, spinal cord, skeletal muscle and heart. Defects in SCN4B are the cause of long QT syndrome type 10 (LQT10) [MIM:611819]. Long QT syndromes are heart disorders characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to exercise or emotional stress. They can present with a sentinel event of sudden cardiac death in infancy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: sodium channel accessory subunit; sodium channel beta 4 subunit; Sodium channel regulatory subunit beta-4; sodium channel subunit beta-4; sodium channel, type IV, beta polypeptide; sodium channel, voltage gated, type IV beta subunit; sodium channel, voltage-gated, type IV, beta subunit; voltage gated sodium channel beta 4 subunit
Gene Aliases: ATFB17; Gm1471; LQT10; Navbeta4; SCN4B
UniProt ID: (Human) Q8IWT1, (Mouse) Q7M729
Entrez Gene ID: (Human) 6330, (Mouse) 399548
transport
ion transport
sodium ion transport
positive regulation of sodium ion transport
regulation of ion transmembrane transport
sodium ion transmembrane transport
cardiac muscle contraction
regulation of ventricular cardiac muscle cell membrane repolarization
cardiac muscle cell action potential involved in contraction
membrane depolarization during cardiac muscle cell action potential
AV node cell action potential
regulation of heart rate by cardiac conduction
regulation of sodium ion transmembrane transporter activity
regulation of postsynaptic membrane potential
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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