Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Product Details
H00006334-M04
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
4G7
Immunogen
SCN8A (NP_055006, 1854 a.a. approximately 1951 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
0.5-1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Immunogen sequence: RVLGDSGELD ILRQQMEERF VASNPSKVSY EPITTTLRRK QEEVSAVVLQ RAYRGHLARR GFICKKTTSN KLENGGTHRE KKESTPSTAS LPSYDSVT
Target Information
The sodium channel protein type 8 subunit alpha (Na+ CP type VIII alpha ) is a multi-pass, transmembrane protein that mediates the sodium ion permeability of excitable membranes. The three glycoproteins that comprise the voltage-gated sodium channel proteins include a pore-forming alpha subunit, a noncovalently associated beta1 subunit and a disulfide-linked beta2 subunit. The two beta subunits regulate the level of channel expression, modulate gating and function as cell adhesion molecules for cellular aggregation and cytoskeleton interaction. The alpha subunits of sodium channels type I and III are predominantly expressed in neuronal cell bodies and proximal processes, while type II alpha subunits are more abundant along axons. Sodium channels are important for rapid signal transduction but also play a significant role in neuronal development. Defects of the SCN8A gene have exhibited detrimental effects on the growth of secondary motoneurons. Loss of SCN8A expression will result in progressive paralysis and early death.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: ataxia 3; hNa6/Scn8a voltage-gated sodium channel; Scn8a (PN4); Sodium channel protein type 8 subunit alpha; Sodium channel protein type VIII subunit alpha; sodium channel, voltage gated, type VIII alpha subunit; sodium channel, voltage gated, type VIII, alpha subunit; Voltage-gated sodium channel subunit alpha Nav1.6; voltage-gated sodium channel type VIII alpha protein
Gene Aliases: AI853486; C630029C19Rik; CERIII; CIAT; dmu; EIEE13; MED; mnd-2; mnd2; NaCh6; Nav1.6; Nbna1; nmf2; nmf335; nmf58; nur14; PN4; SCN8A; seal
UniProt ID: (Human) Q9UQD0, (Mouse) Q9WTU3
Entrez Gene ID: (Human) 6334, (Mouse) 20273
sodium ion transport
nervous system development
peripheral nervous system development
neuronal action potential
regulation of ion transmembrane transport
sodium ion transmembrane transport
myelination
regulation of postsynaptic membrane potential
membrane depolarization during action potential
transport
ion transport
muscle organ development
sensory perception of sound
locomotory behavior
adult walking behavior
adult locomotory behavior
response to toxic substance
neuromuscular process
transmembrane transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support