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Invitrogen
SCNN1D Polyclonal Antibody
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FIGURE: 1 / 1
SCNN1D Antibody (PA5-87738) in WB
Western blot analysis of SCNN1D in extracts of various cell lines. Samples were incubated with SCNN1D Polyclonal antibody (Product # PA5-87738) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.
Product Details
PA5-87738
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 540-680 of human SCNN1D (NP_0011238852)
Conjugate
Form
Liquid
Concentration
0.8 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2804377
Product Specific Information
Immunogen sequence: GVEVELLHNT SYTRQACLVS CFQQLMVETC SCGYYLHPLP AGAEYCSSAR HPAWGHCFYR LYQDLETHRL PCTSRCPRPC RESAFKLSTG TSRWPSAKSA GWTLATLGEQ GLPHQSHRQR SSLAKINIVY QELNYRSVEE A; Positive Samples: U-87MG, A-549, MCF-7, Mouse brain, Mouse liver, Rat brain, Rat liver; Cellular Location: Cell membrane, Multi-pass membrane protein
Target Information
SNX6 interacts with members of the transforming growth factor-beta family of receptor serine-threonine kinases. These receptors belong to two classes: type II receptors that bind ligand, and type I receptors that are subsequently recruited to transduce the signal. Of the type II receptors, SNX6 was found to interact strongly with ActRIIB and more moderately with wild type and kinase-defective mutants of TbetaRII. Of the type I receptors, SNX6 was found to interact only with inactivated TbetaRI. SNXs 1-4 also interacted with the transforming growth factor-beta receptor family, showing different receptor preferences. Conversely, SNX6 behaved similarly to the other SNX proteins in its interactions with receptor tyrosine kinases. Strong heteromeric interactions were also seen among SNX1, -2, -4, and -6, suggesting the formation in vivo of oligomeric complexes. These findings are the first evidence for the association of the SNX family of molecules with receptor serine-threonine kinases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Amiloride-sensitive sodium channel subunit delta; Delta-ENaC; Delta-NaCH; epithelial Na(+) channel subunit delta; Epithelial sodium channel subunit delta; MGC149710; Nonvoltage-gated sodium channel 1 subunit delta; SCNED; sodium channel, non voltage gated 1 delta subunit; sodium channel, non-voltage-gated 1, delta subunit; sodium channel, nonvoltage-gated 1, delta; sodium channel, voltage-gated, type I, delta polypeptide
Gene Aliases: DNACH; ENaCd; ENaCdelta; SCNED; SCNN1D
UniProt ID: (Human) P51172
Entrez Gene ID: (Human) 6339, (Rat) 103692528
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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