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Proteintech
SCO1 Polyclonal Antibody
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Product Details
12614-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
SCO1 Fusion Protein Ag3269 (1-301 aa encoded by BC015504)
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MAMLVLVPG RVMRPLGGQL WRFLPRGLEF WGPAEGTARV LLRQFCARQA EAWRASGRPG YCLGTRPLST ARPPPPWSQK GPGDSTRPSK PGPVSWKSLA ITFAIGGALL AGMKHVKKEK AEKLEKERQR HIGKPLLGGP FSLTTHTGER KTDKDYLGQW LLIYFGFTHC PDVCPEELEK MIQVVDEIDS ITTLPDLTPL FISIDPERDT KEAIANYVKE FSPKLVGLTG TREEVDQVAR AYRVYYSPGP KDEDEDYIVD HTIIMYLIGP DGEFLDYFGQ NKRKGEIAAS IATHMRPYRK KS (1-301 aa encoded by BC015504)
Target Information
Synthesis of cytochrome c oxidase 1 was initially identified in yeast as one of two cytochrome c oxidase (COX) assembly proteins that enable the assembly of cytochrome c holoenzyme, a complex that catalyzes the transfer of reducing equivalents from cytochrome c to molecular oxygen and pumps protons across the inner mitochondrial membrane. Like their yeast homologs, the function of both SCO1 and SCO2 are dependent on copper ion binding. Mutations in either gene can lead to cytochrome c oxidase respiratory chain defects, with a missense mutation in human SCO1 (P174L) associated with a fatal neonatal hepatopathy when the second allele is also non-functional, suggesting the pathology is due to loss of function. It has been suggested that this mutation alters the SCO1 affinity for the copper (I) ion, thus impairing the efficiency of copper transfer to the cytochrome c oxidase.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Protein SCO1 homolog, mitochondrial; SCO cytochrome oxidase deficient homolog 1
Gene Aliases: SCO1; SCOD1
UniProt ID: (Human) O75880
Entrez Gene ID: (Human) 6341
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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